Louise Berg

Principal Investigator

Karolinska Institutet

Louise Berg has a basic training in biology from Stockholm University and did her doctoral studies at the Karolinska Institutet, Stockholm, within the field of inflammation, obtaining a PhD in 2000. She spent the following 10 years first as a post doctoral fellow and then as a group leader studying viral infections and natural killer cell biology at the Karolinska Institutet. Following this, Louise was recruited to lead a collaboration between Karolinska Institutet and the pharmaceutical company Novo Nordisk. As such, her function was to coodinate the work characterizing target expression and function in cells from patients with inflammatory diseases. She was also involved in organizing the process of cloning and producing patient derived monoclonal antibodies, from patients with rheumatoid arthritis.
 

Research Areas

The Tissue Platform workgroup within autoimmune inflammatory diseases at Karolinska Institutet studies the effects of probes in cell assays relevant for the diseases we study, ie systemic lupus erythematosus, idiopathic inflammatory myositis, systemic sclerosis and inflammatory bowel disease. The cell assays are based on blood samples or tissue biopsies from these patients, and readouts are either specific, such as antibody production or the production of proinflammatory cytokines, or wider, such as proteomic effects of the probes. The effect of SGC probes, or probes obtained in collaboration with academic groups or industry, are screened using these assays.
 

Group Members

  • Yvonne Sundström
  • Mingmei Shang
Herpes simplex virus specific T cell response in a cohort with primary genital infection correlates inversely with frequency of subsequent recurrences. Sexually transmitted infections 2016
Franzen-Röhl E, Schepis D, Atterfelt F, Franck K, Wikström A, Liljeqvist JÅ, Bergström T, Aurelius E, Kärre K, Berg L, Gaines H.
BMJ Journals. 2016 . doi: 10.1136/sextrans-2016-052811
PMID:

Integration of Known DNA, RNA and Protein Biomarkers Provides Prediction of Anti-TNF Response in Rheumatoid Arthritis: Results from the COMBINE Study
Folkersen L, Brynedal B, Diaz-Gallo LM, Ramskold D, Shchetynsky K, Westerlind H, Sundstrom Y, Schepis D, Hensvold A, Vivar N, Eloranta ML, Ronnblom L, Brunak S, Malmstrom V, Catrina A, Moerch UGW, Klareskog L, Padyukov L, Berg L.
Mol Med.. 2016 322-328. doi: 10.2119/molmed.2016.00078
PMID: 27532898

Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Nielsen N, Pascal V, Fasth AER, Sundstrom Y, Galsgaard ED, Ahern D, Andersen M, Baslund B, Bartels EM, Bliddal H, Feldmann M, Malmstrom V, Berg L, Spee P, Soderstrom K.
Immunology.. 2014 142(4):581-9. doi: 10.1111/imm.12271
PMID: 24673109

Increased Cell-Mediated Immune Responses in Patients with Recurrent Herpes Simplex Virus Type 2 Meningitis
Franzen-Rohl E, Schepis D, Lagrelius M, Franck K, Jones P, Liljeqvist JA, Bergstrom T, Aurelius E, Karre K, Berg L, Gaines H.
Clin Vaccine Immunol. 2011 18(4):655-60. doi: 10.1128/CVI.00333-10
PMID: 21325490

NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients
Johansson SE, Hejdeman B, Hinkula J, Johansson MH, Romagne F, Wahren B, Wagtmann NR, Karre K, Berg L.
Clin Immunol. . 2010 134(2):158-68. doi: 10.1016/j.clim.2009.10.001
PMID: 19880352

Herpesvirus Seropositivity in Childhood Associates with Decreased Monocyte-Induced NK Cell IFN-gamma Production
Saghafian-Hedengren S, Sundstrom Y, Sohlberg E, Nilsson C, Linde A, Troye-Blomberg M, Berg L, Sverremark-Ekstrom E.
J Immunol. 2009 182(4):2511-7. doi: 10.4049/jimmunol.0801699
PMID: 19201907

LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients
Berg L, Riise GC, Cosman D, Bergstrom T, Olofsson S, Karre W, Carbone E.
Lancet. . 2003 361(9363):1099-101. doi: 10.1016/S0140-6736(03)12855-3
PMID: 12672315

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.
Prokunina L, Castillejo-Lopez C, Oberg F, Gunnarsson I, Berg L, Magnusson V, Brookes AJ, Tentler D, Kristjansdottir H, Grondal G, Bolstad AI, Svenungsson E, Lundberg I, Sturfelt G, Jonssen A, Truedsson L, Lima G, Alcocer-Varela J, Jonsson R, Gyllensten UB, Harley JB, Alarcon-Segovia D, Steinsson K, Alarcon-Riquelme ME.
Nat Genet.. 2002 32(4):666-9. doi: 10.1038/ng1020
PMID: 12402038

2016

Herpes simplex virus specific T cell response in a cohort with primary genital infection correlates inversely with frequency of subsequent recurrences. Sexually transmitted infections 2016
Franzen-Röhl E, Schepis D, Atterfelt F, Franck K, Wikström A, Liljeqvist JÅ, Bergström T, Aurelius E, Kärre K, Berg L, Gaines H.
BMJ Journals. 30.11.2016 . doi: 10.1136/sextrans-2016-052811
PMID:

Integration of Known DNA, RNA and Protein Biomarkers Provides Prediction of Anti-TNF Response in Rheumatoid Arthritis: Results from the COMBINE Study
Folkersen L, Brynedal B, Diaz-Gallo LM, Ramskold D, Shchetynsky K, Westerlind H, Sundstrom Y, Schepis D, Hensvold A, Vivar N, Eloranta ML, Ronnblom L, Brunak S, Malmstrom V, Catrina A, Moerch UGW, Klareskog L, Padyukov L, Berg L.
Mol Med.. 15 Aug 2016 322-328. doi: 10.2119/molmed.2016.00078
PMID: 27532898

2014

Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram
Svenningsson P, Berg L, Matthews D, Ionescu DF, Richards EM, Niciu MJ, Malinger A, Toups M, Manji H, Trivedi MH, Zarate CA, Greengard P.
Mol Psychiatry. Sep 2014 19(9):962-4. doi: 10.1038/mp.2014.13
PMID: 24614495

Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Nielsen N, Pascal V, Fasth AER, Sundstrom Y, Galsgaard ED, Ahern D, Andersen M, Baslund B, Bartels EM, Bliddal H, Feldmann M, Malmstrom V, Berg L, Spee P, Soderstrom K.
Immunology.. 01.08.2014 142(4):581-9. doi: 10.1111/imm.12271
PMID: 24673109

2011

Cell Function and Antibodies Mediating ADCC in HIV-1-Infected Viremic and Controller Patients
Johansson SE, Rollman E, Chung AW, Center RJ, Hejdeman B, Stratov I, Hinkula J, Wahren B, Karre K, Kent SJ, Berg L. NK
Viral Immunol. Oct. 2011 24(5):359-68. doi: 10.1089/vim.2011.0025
PMID: 21958370

Increased Cell-Mediated Immune Responses in Patients with Recurrent Herpes Simplex Virus Type 2 Meningitis
Franzen-Rohl E, Schepis D, Lagrelius M, Franck K, Jones P, Liljeqvist JA, Bergstrom T, Aurelius E, Karre K, Berg L, Gaines H.
Clin Vaccine Immunol. 01.04.2011 18(4):655-60. doi: 10.1128/CVI.00333-10
PMID: 21325490

Fetal and adult multipotent mesenchymal stromal cells are killed by different pathways
Gotherstrom C, Lundqvist A, Duprez IR, Childs R, Berg L, le Blanc K.
Cytotherapy. March 2011 13(3):269-78. doi: 10.3109/14653249.2010.523077
PMID: 20942778

2010

Characterization of long-term mixed donor-donor chimerism after double cord blood transplantation
Gertow J, Berglund S, Okas M, Uzunel M, Berg L, Karre K, Mattsson J, Uhlin M
Clin Exp Immunol.. 2010 Oct. 162(1):146-5. doi: 10.1111/j.1365-2249.2010.04212.x
PMID: 20731674

NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients
Johansson SE, Hejdeman B, Hinkula J, Johansson MH, Romagne F, Wahren B, Wagtmann NR, Karre K, Berg L.
Clin Immunol. . 01.02.2010 134(2):158-68. doi: 10.1016/j.clim.2009.10.001
PMID: 19880352

AIRE deficiency leads to impaired iNKT cell development
Lindh E, Rosmaraki E, Berg L, Brauner H, Karlsson MCI, Peltonen L, Hoglund P, Winqvist O
J Autoimmun. Feb. 2010 34(1):66-72. doi: 10.1016/j.jaut.2009.07.002
PMID: 19651488

2009

Herpes Simplex Virus Infection Downmodulates NKG2D Ligand Expression
Schepis D, D'Amato M, Studahl M, Bergstrom T, Karre K, Berg L.
Scand J Immunol. 2009 May 69(5):429-36. doi: 10.1111/j.1365-3083.2009.02241.x
PMID: 19508374

Herpesvirus Seropositivity in Childhood Associates with Decreased Monocyte-Induced NK Cell IFN-gamma Production
Saghafian-Hedengren S, Sundstrom Y, Sohlberg E, Nilsson C, Linde A, Troye-Blomberg M, Berg L, Sverremark-Ekstrom E.
J Immunol. 15 Feb 2009 182(4):2511-7. doi: 10.4049/jimmunol.0801699
PMID: 19201907

Increased proportion of CD56(bright) natural killer cells in active and inactive systemic lupus erythematosus
Schepis D, Gunnarsson I, Eloranta ML, Lampa J, Jacobson SH, Karre K, Berg L
Immunology. 2009 Jan. 126(1):140-6. doi: 10.1111/j.1365-2567.2008.02887.x
PMID: 18564343

2008

Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation
Lieke T, Nylen S, Eidsmo L, McMaster WR, Mohammadi AM, Khamesipour A, Berg L, Akuffo H.
Clin Exp Immunol.. 2008 Aug. 153(2):221-30. doi: 10.1111/j.1365-2249.2008.03687.x
PMID: 18713141

Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection
Titanji K, Sammicheli S, De Milito A, Mantegani P, Fortis C, Berg L, Karre K, Travi G, Tassandin C, Lopalco L, Rethi B, Tambussi G, Chiodi F.
Immunolog. 2008 Feb. 123(2):164-70. doi: 10.1111/j.1365-2567.2007.02657.x
PMID: 17627773

2007

Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion
de Matos CT, Berg L, Michaelsson J, Fellander-Tsai L, Karre K, Soderstrom K.
Immunology. 2007 Oct. 122(2):291-301. doi: 10.1111/j.1365-2567.2007.02638.x
PMID: 17521371

The expression of human natural killer cell receptors in early life
Sundstrom Y, Nilsson C, Lilja G, Karre K, Troye-Blomberg M, Berg L.
Scand J Immunol.. Aug-Sep 2007 66(2-3):335-44. doi: 10.1111/j.1365-3083.2007.01980.x
PMID: 17635811

Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infection
Wagner CS, Riise GC, Bergstrom T, Karre K, Carbone E, Berg L.
J Immunol.. 2007 Mar 15 178(6):3536-43. doi: 10.4049/jimmunol.178.6.3536
PMID: 17339449

2006

Normal NK cell development in absence of Aire.
Lundgren EK, Rosmaraki E, Berg L, Hoglund P, Winqvist O
Journal of Immunology. 2006 176; S280-S280. doi:
PMID:

NK cells in autoimmune disease
Johansson S, Hall H, Berg L, Hoglund P.
Immunobiology of Natural Killer Cell Receptors. 2006 298; 259-77. doi:
PMID:

2005

NK cells: elusive players in autoimmunity
Johansson S, Berg L, Hall H, Hoglund P.
Trends Immunol. Nov. 2005 26(11):613-8. doi: 10.1016/j.it.2005.08.008
PMID: 16118064

2003

LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients
Berg L, Riise GC, Cosman D, Bergstrom T, Olofsson S, Karre W, Carbone E.
Lancet. . 29.03.2003 361(9363):1099-101. doi: 10.1016/S0140-6736(03)12855-3
PMID: 12672315

2002

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.
Prokunina L, Castillejo-Lopez C, Oberg F, Gunnarsson I, Berg L, Magnusson V, Brookes AJ, Tentler D, Kristjansdottir H, Grondal G, Bolstad AI, Svenungsson E, Lundberg I, Sturfelt G, Jonssen A, Truedsson L, Lima G, Alcocer-Varela J, Jonsson R, Gyllensten UB, Harley JB, Alarcon-Segovia D, Steinsson K, Alarcon-Riquelme ME.
Nat Genet.. 01 Dec 2002 32(4):666-9. doi: 10.1038/ng1020
PMID: 12402038

2001

Increased peripheral T cell reactivity to microbial antigens and collagen type II in rheumatoid arthritis after treatment with soluble TNF alpha receptors.
Berg L, Lampa J, Rogberg S, van Vollenhoven R, Klareskog L.
Ann Rheum Dis. 2001 Feb 60(2):133-9. doi:
PMID: 11156546

2000

T-cell reactivity to collagen type II in rheumatoid arthritis is associated with HLA-DR4 and HLA-DQ8
Berg L, Ronnelid J, Sanjeevi CB, Lampa J, Klareskog L.
Arthritis Res. 2000 2(1):75-84.. doi: 10.1186/ar71
PMID: 11219392

T-cell receptor CD3 zeta chain expression in rheumatoid arthritis and its influence on in vitro cellular hyporesponsiveness
Berg L, Ronnelid J, Klareskog L, Bucht A.
Clin Exp Immunol. April 2000 120(1):174-82.. doi:
PMID: 10759780

Down-regulation of the T cell receptor CD3 zeta chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness
Berg L, Ronnelid J, Klareskog L, Bucht A.
Clin Exp Immunol. April 2000 120(1):174-82. doi:
PMID: 10759780

1998

Increased serum levels of immunoglobulins, C-reactive protein, type 1 and type 2 cytokines in patients with mixed connective tissue disease
Hassan AB, Ronnelid J, Gunnarsson I, Karlsson G, Berg L, Lundberg I.
J Autoimmun. Oct 1998 11(5):503-8. doi: 10.1006/jaut.1998.0236
PMID: 9802936

Production of T-cell cytokines at the single-cell level in patients with inflammatory arthritides: Enhanced activity in synovial fluid compared to blood.
Ronnelid J, Berg L, Rogberg S, Nilsson A, Albertsson K, Klareskog L.
Br J Rheumatol. 1998 Jan 37(1):7-14.. doi:
PMID: 9487244

1996

Induction of cytotoxic T-cell response by optimal-length peptides does not require CD4(+) T-cell help
Fayolle C, AbdelMotal UM, Berg L, Deriaud E, Jondal M, Leclerc C.
Immunology. Sep 1996 ;89(1):41-5.. doi:
PMID: 8911138

Immunization with glycosylated K-b-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells
AbdelMotal UM, Berg L, Rosten A, Bengtsson M, Thorpe CJ, Kihlberg J, Dahmen J, Magnusson G, Karlsson KA, Jondal M.
European Journal of Immunology. 1996 26;3 544-551. doi:
PMID:

Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells
Abdel-Motal UM, Berg L, Rosén A, Bengtsson M, Thorpe CJ, Kihlberg J, Dahmén J, Magnusson G, Karlsson KA, Jondal M.
Eur J Immunol. 1996 Mar 26(3):544-51.. doi: 10.1002/eji.1830260307
PMID: 8605919

1995

Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules
AbdelMotal UM, Berg L, Bengtsson M, Dahmen J, Kihlberg J, Magnusson G, Nilsson U, Jondal M.
J Immunol Methods. 15 Dec 1995 188(1):21-31. doi:
PMID: 8551035

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