Matthieu Schapira

Principal Investigator

University of Toronto

Matthieu holds a M.Sc degree in chemistry from the National Superior Chemistry School, Nancy, France, and a Ph.D in biochemistry from Ecole Normale Superieure, Paris. After graduating in 1995, he completed a couple post-docs in protein crystallography and computational chemistry at New York University Medical Center. In 2000, he joined Molsoft, a San-Diego based biotech, as senior research scientist. In 2003, he moved to Lyon, France, to lead structure-based drug design at Aptanomics/Imaxio, a drug discovery start-up. In 2007, he joined the SGC as head of research informatics. Matthieu holds an Associate Professor cross-appointment with the Department of Pharmacology and Toxicology at University of Toronto.

Research Areas

SGC Toronto’s Research Informatics group has three distinct roles. (1) Research: we apply computational chemistry tools to analyze protein structures and support the development of chemical inhibitors. We also analyze cancer genomics data. (2) Tools: we develop web interfaces, such as Chromohub, to easily navigate structural, chemical and genomic data. (3) Databases: we manage the wealth of biological and chemical data generated at SGC-Toronto.

Group Members

  • Renato Freitas
  • Lihua Liu
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
Ferreira de Freitas R, Eram MS, Szewczyk MM, Steuber H, Smil D, Wu H, Li F, Senisterra G, Dong A, Brown PJ, Hitchcock M, Moosmayer D, Stegmann CM, Egner U, Arrowsmith C, Barsyte-Lovejoy D, Vedadi M, Schapira M
J. Med. Chem.. 2016 . doi: 10.1021/acs.jmedchem.5b01772
PMID: 26824386

Probing the epigenome.
Huston A, Arrowsmith CH, Knapp S, Schapira M
Nat. Chem. Biol.. 2015 11(8):542-5. doi: 10.1038/nchembio.1871
PMID: 26196765

Discovery of a Dual PRMT5-PRMT7 Inhibitor.
Smil D, Eram MS, Li F, Kennedy S, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M
ACS Med Chem Lett. 2015 6(4):408-12. doi: 10.1021/ml500467h
PMID: 25893041

A global assessment of cancer genomic alterations in epigenetic mechanisms.
Shah MA, Denton EL, Arrowsmith CH, Lupien M, Schapira M
Epigenetics Chromatin. 2014 7(1):29. doi: 10.1186/1756-8935-7-29
PMID: 25484917

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M
Nat Commun. 2012 3:1288. doi: 10.1038/ncomms2304
PMID: 23250418

Epigenetic protein families: a new frontier for drug discovery.
Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M
Nat Rev Drug Discov. 2012 11(5):384-400. doi: 10.1038/nrd3674
PMID: 22498752

Druggability of methyl-lysine binding sites
Santiago C,Nguyen K,Schapira M
J Comput Aided Mol Des.. 2011 25 (12):1171-8. doi: 10.1007/s10822-011-9505-2
PMID: 22146969

2016

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.
Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC, Filippakopoulos P
Cell Rep. 06.12.2016 17(10):2724-2737. doi: 10.1016/j.celrep.2016.11.014
PMID: 27926874

Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.
Shen Y, Szewczyk MM, Eram MS, Smil D, Kaniskan HÜ, de Freitas RF, Senisterra G, Li F, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J
J. Med. Chem.. 01.09.2016 . doi: 10.1021/acs.jmedchem.6b01033
PMID: 27584694

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.
Spurr SS, Bayle ED, Yu W, Li F, Tempel W, Vedadi M, Schapira M, Fish PV
Bioorg. Med. Chem. Lett.. 21.07.2016 . doi: 10.1016/j.bmcl.2016.07.041
PMID: 27485386

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.
Ferreira de Freitas R, Eram MS, Smil D, Szewczyk MM, Kennedy S, Brown PJ, Santhakumar V, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M
J. Med. Chem.. 08.07.2016 . doi: 10.1021/acs.jmedchem.6b00668
PMID: 27390919

Methyltransferase inhibitors for modulation of the epigenome and beyond.
Schapira M, Arrowsmith CH
Curr Opin Chem Biol. 16.06.2016 33:81-87. doi: 10.1016/j.cbpa.2016.05.030
PMID: 27318562

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates.
Ahmed H, Duan S, Arrowsmith CH, Barsyte-Lovejoy D, Schapira M
J. Proteome Res.. 10.05.2016 . doi: 10.1021/acs.jproteome.6b00220
PMID: 27163177

PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase.
Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi M
J. Biol. Chem.. 29.04.2016 . doi: 10.1074/jbc.M116.721472
PMID: 27129774

Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18.
Simpson C, Jones NG, Hull-Ryde EA, Kireev D, Stashko M, Tang K, Janetka J, Wildman SA, Zuercher WJ, Schapira M, Hui R, Janzen W, Sibley LD
ACS Infect Dis. 11.03.2016 2(3):194-206. doi: 10.1021/acsinfecdis.5b00102
PMID: 27379343

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).
Getlik M, Smil D, Zepeda-Velázquez C, Bolshan Y, Poda G, Wu H, Dong A, Kuznetsova E, Marcellus R, Senisterra G, Dombrovski L, Hajian T, Kiyota T, Schapira M, Arrowsmith CH, Brown PJ, Vedadi M, Al-Awar R
J. Med. Chem.. 09.03.2016 . doi: 10.1021/acs.jmedchem.5b01630
PMID: 26958703

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
Ferreira de Freitas R, Eram MS, Szewczyk MM, Steuber H, Smil D, Wu H, Li F, Senisterra G, Dong A, Brown PJ, Hitchcock M, Moosmayer D, Stegmann CM, Egner U, Arrowsmith C, Barsyte-Lovejoy D, Vedadi M, Schapira M
J. Med. Chem.. 29.01.2016 . doi: 10.1021/acs.jmedchem.5b01772
PMID: 26824386

2015

Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18
Simpson C, Jones N, Hull-Ryde E, Kireev D, Stashko M, Tang K, Janetka J, Wildman S, Zuercher W, Schapira M, Hui R, Janzen W, Sibley LD.
ACS Infect. Dis.. 28.12.2015 2(3):194-206. doi: 10.1021/acsinfecdis.5b00102
PMID:

A Potent, Selective and Cell-active Inhibitor of Human Type I Protein Arginine Methyltransferases.
Eram MS, Shen Y, Szewczyk M, Wu H, Senisterra G, Li F, Butler KV, Kaniskan HÜ, Speed BA, Dela Seña C, Dong A, Zeng H, Schapira M, Brown PJ, Arrowsmith CH, Barsyte-Lovejoy D, Liu J, Vedadi M, Jin J
ACS Chem. Biol.. 24.11.2015 . doi: 10.1021/acschembio.5b00839
PMID: 26598975

STRUCTURAL BIOLOGY. Chromatin complex, crystal clear.
Schapira M
Science. 16.10.2015 350(6258):278-9. doi: 10.1126/science.aad5203
PMID: 26472895

Probing the epigenome.
Huston A, Arrowsmith CH, Knapp S, Schapira M
Nat. Chem. Biol.. 21.07.2015 11(8):542-5. doi: 10.1038/nchembio.1871
PMID: 26196765

The promise and peril of chemical probes.
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ
Nat. Chem. Biol.. 21.07.2015 11(8):536-41. doi: 10.1038/nchembio.1867
PMID: 26196764

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G
Nat. Chem. Biol.. 13.07.2015 . doi: 10.1038/nchembio.1859
PMID: 26167872

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2.
Eram MS, Kuznetsova E, Li F, Lima-Fernandes E, Kennedy S, Chau I, Arrowsmith CH, Schapira M, Vedadi M
Biochim. Biophys. Acta. 19.05.2015 . doi: 10.1016/j.bbagen.2015.05.013
PMID: 26002201

Structural diversity of the epigenetics pocketome.
Cabaye A, Nguyen KT, Liu L, Pande V, Schapira M
Proteins. 13.05.2015 . doi: 10.1002/prot.24830
PMID: 25974248

Discovery of a Dual PRMT5-PRMT7 Inhibitor.
Smil D, Eram MS, Li F, Kennedy S, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M
ACS Med Chem Lett. 09.04.2015 6(4):408-12. doi: 10.1021/ml500467h
PMID: 25893041

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).
Kaniskan HÜ, Szewczyk MM, Yu Z, Eram MS, Yang X, Schmidt K, Luo X, Dai M, He F, Zang I, Lin Y, Kennedy S, Li F, Dobrovetsky E, Dong A, Smil D, Min SJ, Landon M, Lin-Jones J, Huang XP, Roth BL, Schapira M, Atadja P, Barsyte-Lovejoy D, Arrowsmith CH, Brown PJ, Zhao K, Jin J, Vedadi M
Angew. Chem. Int. Ed. Engl.. 27.02.2015 . doi: 10.1002/anie.201412154
PMID: 25728001

2014

Structural biology and chemistry of protein arginine methyltransferases.
Schapira M, Ferreira de Freitas R
Medchemcomm. 19.12.2014 5(12):1779-1788. doi: 10.1039/c4md00269e
PMID: 26693001

BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.
Gu L, Frommel SC, Oakes CC, Simon R, Grupp K, Gerig CY, Bär D, Robinson MD, Baer C, Weiss M, Gu Z, Schapira M, Kuner R, Sültmann H, Provenzano M, Yaspo ML, Brors B, Korbel J, Schlomm T, Sauter G, Eils R, Plass C, Santoro R
Nat. Genet.. 08.12.2014 . doi: 10.1038/ng.3165
PMID: 25485837

A global assessment of cancer genomic alterations in epigenetic mechanisms.
Shah MA, Denton EL, Arrowsmith CH, Lupien M, Schapira M
Epigenetics Chromatin. 04.12.2014 7(1):29. doi: 10.1186/1756-8935-7-29
PMID: 25484917

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH
Proc. Natl. Acad. Sci. U.S.A.. 18.08.2014 . doi: 10.1073/pnas.1407358111
PMID: 25136132

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9.
Eram MS, Bustos SP, Lima-Fernandes E, Siarheyeva A, Senisterra G, Hajian T, Chau I, Duan S, Wu H, Dombrovski L, Schapira M, Arrowsmith CH, Vedadi M
J. Biol. Chem.. 14.03.2014 . doi: 10.1074/jbc.M113.523183
PMID: 24634223

A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro.
Allali-Hassani A, Kuznetsova E, Hajian T, Wu H, Dombrovski L, Li Y, Gräslund S, Arrowsmith CH, Schapira M, Vedadi M
J Biomol Screen. 04.03.2014 . doi: 10.1177/1087057114525854
PMID: 24595546

2013

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations.
Wu H, Zeng H, Dong A, Li F, He H, Senisterra G, Seitova A, Duan S, Brown PJ, Vedadi M, Arrowsmith CH, Schapira M
PLoS ONE. 19.12.2013 8(12):e83737. doi: 10.1371/journal.pone.0083737
PMID: 24367611

ChromoHub V2: Cancer Genomics.
Shah MA, Denton EL, Liu L, Schapira M
Bioinformatics. 06.12.2013 . doi: 10.1093/bioinformatics/btt710
PMID: 24319001

Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J
FEBS Lett.. 29.11.2013 587(23):3859-68. doi: 10.1016/j.febslet.2013.10.020
PMID: 24396869

Bromo-deaza-SAH: A potent and selective DOT1L inhibitor.
Yu W, Smil D, Li F, Tempel W, Fedorov O, Nguyen KT, Bolshan Y, Al-Awar R, Knapp S, Arrowsmith CH, Vedadi M, Brown PJ, Schapira M
Bioorg. Med. Chem.. 01.04.2013 21(7):1787-94. doi: 10.1016/j.bmc.2013.01.049
PMID: 23433670

Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamides.
Li B, Tempel W, Smil D, Bolshan Y, Schapira M, Park HW
Proteins. 30.03.2013 . doi: 10.1002/prot.24290
PMID: 23553820

Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors.
Liu F, Li F, Ma A, Dobrovetsky E, Dong A, Gao C, Korboukh I, Liu J, Smil D, Brown PJ, Frye SV, Arrowsmith CH, Schapira M, Vedadi M, Jin J
J. Med. Chem.. 14.03.2013 56(5):2110-24. doi: 10.1021/jm3018332
PMID: 23445220

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.
Bolshan Y, Getlik M, Kuznetsova E, Wasney GA, Hajian T, Poda G, Nguyen KT, Wu H, Dombrovski L, Dong A, Senisterra G, Schapira M, Arrowsmith CH, Brown PJ, Al-Awar R, Vedadi M, Smil D
ACS Med Chem Lett. 14.03.2013 4(3):353-7. doi: 10.1021/ml300467n
PMID: 24900672

Strategy to Target the Substrate Binding site of SET Domain Protein Methyltransferases.
Nguyen KT, Li F, Poda G, Smil D, Vedadi M, Schapira M
J Chem Inf Model. 01.03.2013 . doi: 10.1021/ci300596x
PMID: 23410263

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Senisterra G, Wu H, Allali-Hassani A, Wasney GA, Barsyte-Lovejoy D, Dombrovski L, Dong A, Nguyen KT, Smil D, Bolshan Y, Hajian T, He H, Seitova A, Chau I, Li F, Poda G, Couture JF, Brown PJ, Al-Awar R, Schapira M, Arrowsmith CH, Vedadi M
Biochem. J.. 01.01.2013 449(1):151-9. doi: 10.1042/BJ20121280
PMID: 22989411

2012

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M
Nat Commun. 18.12.2012 3:1288. doi: 10.1038/ncomms2304
PMID: 23250418

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.
Zheng W, Ibáñez G, Wu H, Blum G, Zeng H, Dong A, Li F, Hajian T, Allali-Hassani A, Amaya MF, Siarheyeva A, Yu W, Brown PJ, Schapira M, Vedadi M, Min J, Luo M
J. Am. Chem. Soc.. 31.10.2012 134(43):18004-14. doi: 10.1021/ja307060p
PMID: 23043551

ChromoHub: a data hub for navigators of chromatin-mediated signalling.
Liu L, Zhen XT, Denton E, Marsden BD, Schapira M
Bioinformatics. 15.08.2012 28(16):2205-6. doi: 10.1093/bioinformatics/bts340
PMID: 22718786

An allosteric inhibitor of protein arginine methyltransferase 3.
Siarheyeva A, Senisterra G, Allali-Hassani A, Dong A, Dobrovetsky E, Wasney GA, Chau I, Marcellus R, Hajian T, Liu F, Korboukh I, Smil D, Bolshan Y, Min J, Wu H, Zeng H, Loppnau P, Poda G, Griffin C, Aman A, Brown PJ, Jin J, Al-Awar R, Arrowsmith CH, Schapira M, Vedadi M
Structure. 08.08.2012 20(8):1425-35. doi: 10.1016/j.str.2012.06.001
PMID: 22795084

Epigenetic protein families: a new frontier for drug discovery.
Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M
Nat Rev Drug Discov. 13.04.2012 11(5):384-400. doi: 10.1038/nrd3674
PMID: 22498752

2011

Druggability of methyl-lysine binding sites
Santiago C,Nguyen K,Schapira M
J Comput Aided Mol Des.. 12.25.2011 25 (12):1171-8. doi: 10.1007/s10822-011-9505-2
PMID: 22146969

Druggability of methyl-lysine binding sites.
Santiago C, Nguyen K, Schapira M
J. Comput. Aided Mol. Des.. 07.12.2011 25(12):1171-8. doi: 10.1007/s10822-011-9505-2
PMID: 22146969

The Cryptosporidium parvum kinome.
Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P, Hutchinson A, Chau I, von Delft F, MacKenzie F, Lew J, Kozieradzki I, Vedadi M, Schapira M, Zhang C, Shokat K, Heightman T, Hui R
BMC Genomics. 30.09.2011 12:478. doi: 10.1186/1471-2164-12-478
PMID: 21962082

Structural biology of human metal-dependent histone deacetylases.
Schapira M
Handb Exp Pharmacol. 01.09.2011 206:225-40. doi: 10.1007/978-3-642-21631-2_10
PMID: 21879452

Normalizing molecular docking rankings using virtually generated decoys.
Wallach I, Jaitly N, Nguyen K, Schapira M, Lilien R
J Chem Inf Model. 22.08.2011 51(8):1817-30. doi: 10.1021/ci200175h
PMID: 21699246

Structural Chemistry of Human SET Domain Protein Methyltransferases.
Schapira M
Curr Chem Genomics. 22.08.2011 5(Suppl 1):85-94. doi: 10.2174/1875397301005010085
PMID: 21966348

Structural chemistry of the histone methyltransferases cofactor binding site.
Campagna-Slater V, Mok MW, Nguyen KT, Feher M, Najmanovich R, Schapira M
J Chem Inf Model. 28.03.2011 51(3):612-23. doi: 10.1021/ci100479z
PMID: 21366357

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA
Blood. 24.02.2011 117(8):2451-9. doi: 10.1182/blood-2010-11-321208
PMID: 21190999

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R
J. Biol. Chem.. 04.02.2011 286(5):3315-22. doi: 10.1074/jbc.M109.027235
PMID: 21084289

Recognition and specificity determinants of the human cbx chromodomains.
Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, Wasney GA, Li Z, Vedadi M, Schapira M, Min J, Arrowsmith CH
J. Biol. Chem.. 07.01.2011 286(1):521-9. doi: 10.1074/jbc.M110.191411
PMID: 21047797

2010

Newly discovered and characterized antivirulence compounds inhibit bacterial mono-ADP-ribosyltransferase toxins.
Turgeon Z, Jørgensen R, Visschedyk D, Edwards PR, Legree S, McGregor C, Fieldhouse RJ, Mangroo D, Schapira M, Merrill AR
Antimicrob. Agents Chemother.. 06.12.2010 55(3):983-91. doi: 10.1128/AAC.01164-10
PMID: 21135177

Structural genomics of histone tail recognition.
Wang M, Mok MW, Harper H, Lee WH, Min J, Knapp S, Oppermann U, Marsden B, Schapira M
Bioinformatics. 15.10.2010 26(20):2629-30. doi: 10.1093/bioinformatics/btq491
PMID: 20739309

Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity.
Zhao R, Leung E, Grüner S, Schapira M, Houry WA
PLoS ONE. 01.04.2010 5(4):e9934. doi: 10.1371/journal.pone.0009934
PMID: 20376192

Pharmacophore screening of the protein data bank for specific binding site chemistry.
Campagna-Slater V, Arrowsmith AG, Zhao Y, Schapira M
J Chem Inf Model. 22.03.2010 50(3):358-67. doi: 10.1021/ci900427b
PMID: 20112952

Structural biology of human H3K9 methyltransferases.
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M
PLoS ONE. 11.01.2010 5(1):e8570. doi: 10.1371/journal.pone.0008570
PMID: 20084102

2009

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.
Allali-Hassani A, Wasney GA, Chau I, Hong BS, Senisterra G, Loppnau P, Shi Z, Moult J, Edwards AM, Arrowsmith CH, Park HW, Schapira M, Vedadi M
Biochem. J.. 15.11.2009 424(1):15-26. doi: 10.1042/BJ20090723
PMID: 19702579

Evaluation of virtual screening as a tool for chemical genetic applications.
Campagna-Slater V, Schapira M
J Chem Inf Model. 26.08.2009 49(9):2082-91. doi: 10.1021/ci900219u
PMID: 19702241

Substrate recognition and hydrolysis by a fungal xyloglucan-specific family 12 hydrolase.
Powlowski J, Mahajan S, Schapira M, Master ER
Carbohydr. Res.. 06.07.2009 344(10):1175-9. doi: 10.1016/j.carres.2009.04.020
PMID: 19433323

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii.
Qiu W, Wernimont A, Tang K, Taylor S, Lunin V, Schapira M, Fentress S, Hui R, Sibley LD
EMBO J.. 08.04.2009 28(7):969-79. doi: 10.1038/emboj.2009.24
PMID: 19197235

Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways.
Poondra RR, Kumar NN, Bijian K, Prakesch M, Campagna-Slater V, Reayi A, Reddy PT, Choudhry A, Barnes ML, Leek DM, Daroszewska M, Lougheed C, Xu B, Schapira M, Alaoui-Jamali MA, Arya P
J Comb Chem. 09.03.2009 11(2):303-9. doi: 10.1021/cc8001525
PMID: 19146410

Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.
Guo Y, Nady N, Qi C, Allali-Hassani A, Zhu H, Pan P, Adams-Cioaba MA, Amaya MF, Dong A, Vedadi M, Schapira M, Read RJ, Arrowsmith CH, Min J
Nucleic Acids Res.. 20.02.2009 37(7):2204-10. doi: 10.1093/nar/gkp086
PMID: 19233876

2008

Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
Huang X, Finerty P, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S
J. Struct. Biol.. 05.11.2008 165(2):88-96. doi: 10.1016/j.jsb.2008.10.003
PMID: 19028587

Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks.
Prakesch M, Bijian K, Campagna-Slater V, Quevillon S, Joseph R, Wei CQ, Sesmilo E, Reayi A, Poondra RR, Barnes ML, Leek DM, Xu B, Lougheed C, Schapira M, Alaoui-Jamali M, Arya P
Bioorg. Med. Chem.. 01.11.2008 16(21):9596-602. doi: 10.1016/j.bmc.2008.09.025
PMID: 18835181

Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
Schuetz A, Min J, Allali-Hassani A, Schapira M, Shuen M, Loppnau P, Mazitschek R, Kwiatkowski NP, Lewis TA, Maglathin RL, McLean TH, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH
J. Biol. Chem.. 25.04.2008 283(17):11355-63. doi: 10.1074/jbc.M707362200
PMID: 18285338

Structural genomics and drug discovery: all in the family.
Weigelt J, McBroom-Cerajewski LD, Schapira M, Zhao Y, Arrowsmith CH, Arrowmsmith CH
Curr Opin Chem Biol. 07.03.2008 12(1):32-9. doi: 10.1016/j.cbpa.2008.01.045
PMID: 18282486

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