Panagiotis (Takis) Prinos

Team Leader - Epigenetics Cellular Screening

University of Campinas, Unicamp

Panagiotis (Takis) completed his Ph.D. in Human Genetics and Developmental Biology from the University of Connecticut Health Center, Farmington, CT in 1998. After a post-doc on Molecular & Cellular Biology at IRCM in Montreal where he studied signaling pathways and control of gene expression during early embryonic development, he joined Aurelium BioPharma as senior scientist where he led the Cell Biology-Target Validation group from 2002-2006. During the next 5 years, he managed a Genome Canada project on the functional annotation of essential alternatively spliced isoforms in cancer at the Universite de Sherbrooke, Quebec. Subsequently, he directed the functional genomics/phenotypic platform at the Laboratory for Functional Genomics in Sherbrooke, Quebec. He joined the SGC in December, 2014 where he is leading the Oncology patient-derived tumor cell screening activities.

Takis' current interests include cell-based assays and phenotypic screening, assay development and validation, HCS/HTS screens and epigenetic pathways in tumorigenesis, cell survival and proliferation.  

Alternative splicing as a generator of functional diversity in cancer
Prinos, P, Klinck, R, Pereault, JP, Elela, SA, Chabot, B.
Med Sci. 2012 Vol. 1, 4, . doi:

Proteins Associated with the Exon Junction Complex Also Control the Alternative Splicing of Apoptotic Regulators
Michelle L, Toutant J, Thibault P, Durand M, Garneau D, Lapointe E, Couture S, Le Hir H, Klinck R, Abou Elela S, Prinos P and Chabot B.
Mol Cell Biol. 2012 32(5):954-67. doi: 10.1128/MCB.06130-11
PMID: 22203037

Mutation of cysteine 21 inhibits nucleophosmin/B23 oligomerization and chaperone activity
Prinos P, Lacoste MC, Wong J, Bonneau AM, Georges, E.
Int J Biochem Mol Biol. 2011 2(1): 24-30. doi:
PMID: 21968505

RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to antitubulin chemotherapeutics
Georges E, Bonneau AM, Prinos P
Int J Biochem Mol Biol. 2011 2(4):303-8. doi:
PMID: 22187664

SYK alternative splicing regulates mitosis and cancer cell survival
Prinos P, Garneau D, Lucier JF, Gendron D, Couture S, Boivin M, Brosseau JP, Lapointe E, Thibault P, Durand M, Tremblay K, Gervais-Bird J, Nwilati H, Klinck R, Chabot B, Perreault JP, Wellinger RJ, Elela SA.
Nat Struct Mol Biol. 2011 18(6):673-9. doi: 10.1038/nsmb.2040
PMID: 21552259

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