| ||
This family of 18 proteins catalyses the transfer of an acetyl group from Acetyl-CoA to the e-amino group of lysine residues in histones and other non-histone substrates. Unlike histone methyltransferases which are quite specific in the position of methylation, HATs are relatively non-specific and usually acetylate several positions in histones.
Despite numerous screening campaigns involving the screening of over 100,000 compounds, no highly potent inhibitors of HATS have been identified.