Target 2035 brainstorming meeting

11^th July 2018

Hosted by SGC, Bayer AG and Boehringer Ingelheim

Workshop Edit tabs

Details

Aim

The aim of the 'Target 2035' brainstorming meeting is to explore the feasibility and interest in developing a coordinated, open science effort to identify and/or generate high-quality, small molecule modulators for most proteins in the human genome (as current defined).

Specifically we want to consider approaches, scientific and organizational strategies, and feasibility. The desired outcomes are, (1) to agree on whether the concept has merit and (2) to create an action plan for science, funding and organization.

Contact

If you have any questions leading up to the event, feel free to contact kristina.edfeldt@ki.se

Participants

We currently have confirmed participants from the following organisations:

AstraZeneca

Bayer AG

Biogen

Boehringer Ingelheim

Center for Drug Research and Development (CDRD)

Cellzome GmbH

CeMM

Diamond Light Source

EMBL-EBI

ETH Zürich

European Molecular Biology Laboratory (EMBL)

Goethe University Frankfurt

IFOM-The FIRC Institute of Molecular Oncology Foundation

Innovative Medicines Initiative

Janssen

Karolinska Institutet

Lead Discovery Center GmbH

Max Planck Institute for Medical Research

Medical Research Council (UKRI)

Merck KGaA

Montreal Neurological Institute and Hospital, McGill University

MPI Dortmund

NCATS/NIH

Novartis

Ontario Genomics

Ontario Institute for Cancer Research

Pfizer Worldwide R&D

Research Complex at Harwell

RIKEN, Japan

Sanofi-Aventis Deutschland GmbH

Science for Life Laboratory/Karolinska Institutet

SGC

SGC Oxford

SGC-UNC; UNC Eshelman School of Pharmacy

Takeda pharmaceuticals

The Institute of Cancer Research

The Wellcome Trust

UCB

UCSF

University of California, Berkeley

University of Dundee

University of Oxford

University of Toronto-SGC

X-Chem

Download

Target 2035 – The Case

Target 2035 – Meeting Summary 2018-07-11

Programme

Aim: Is it time for chemical biologists to target the complete proteome?

Preparation in advance to save time:

Prior to the meeting, we encourage each attendee to provide one page (no longer) outlining ideas of what they think might be done in the near term (5 years) and what might be ambitious (audacious) priorities for the next 15 years toward the “modulator for each protein in proteome” concept. If attendees read this in advance, then not everyone (hopefully) should feel the need to speak about their own science during the meeting, but be ready to focus on the task in hand.
Please send your one page outline to: kristina.edfeldt@ki.se

Agenda

Target 2035: Chemistry for the proteome
08:00 - 08:30	Registration
08:30 - 09:00	Coffee
09:00 - 09:15	Round table introductions and welcome
09:15 - 09:30	Target 2035 - why this, why now? - Aled Edwards (SGC)
09:30 - 10:15	Imagining 2035: From target to micromolar hit in a day? Brian Shoichet (UCSF): Computational biology Jim Naismith (RCaH): Automation: From chemistry to proven high affinity ligand Daniel Nomura (Cal): Potency and selectivity inside cells? Inside animals? Inside people?
10:15 - 10:45	Imagining 2035: A sharing world Adrian Carter (BI): Enabling experimentalists around the world to contribute Andrew Leach (EBI): Data management and data sharing
10:45 - 11:00	Break
11:00 - 11:30	Organization, governance and investment strategy Michael Dunn (Wellcome): Federation vs single organization Harsukh Parmar (Merck KGaA): Balancing short term aims and long-term vision
11:30 - 12:00	What might be specific, practical goals for next 5 years? Anke Mueller-Fahrnow (Bayer): Balancing deliverables and creativity Cheryl Arrowsmith (Toronto): Balancing creativity and deliverables
12:00 - 12:30	Free discussion
12:30 - 13:30	LUNCH
13:30 - 14:15	Breakout groups for the objectives – what might be our “impossible” aims - Source range of ideas about long term vision/objectives
14:15 - 14:30	Report back from groups - Jim Naismith (RCaH)
14:30 - 15:15	Break-out groups in the focus areas – what might be concrete short-term goals - Source range of ideas about practical short-term vision/objectives
15:15 - 15:30	Report back from groups - Sven Ruf (Sanofi)
15:30 - 15:45	Break/discussion
15:45 - 16:15	Taking a step back: Is it worth pursuing? Are there common themes/recommendations? - Chas Bountra (Oxford-SGC)
16:15 - 16:30	Pharma perspective on what they heard - Alistair Henry (UCB)
16:30 - 16:50	Funders perspective on what they heard
16:50 - 17:00	Sum up - Aled Edwards (SGC)
18:00	Dinner: Two Buddhas, Julie-Wolfthorn-Strasse 1 Note: Live TV for FIFA World Cup 2018 semi finals is available at the Two Buddhas

Location

Venue

The meeting will take place on the premises of
Bayer AG
Müllerstraße 178
13353 Berlin, Germany

Below you will find the logistics how to get to the meeting venue and other important information.

Registration at Bayer
Do not forget your passport in order to register at the main reception. Your welcome envelope will be handed out in the meeting room.

Meeting room
The meeting will take place in building S100, 2^nd floor, room 001. We will pick you up at the main reception and bring you to the room.

WLAN - Bayer Headquarters
Free WiFi will be provided throughout the meeting. Your access data will be handed out as a hardcopy in your welcome envelope.

Your contact persons during the meeting
Dr. Cora Scholten, Tel. +49 175 30 93 609, cora.scholten@bayer.com
Dr. Anke Mueller-Fahrnow, Tel. +49 170 22 65 719, anke.mueller-fahrnow@bayer.com
Iris Scheffler, Tel. + 49 30 468 194790, iris.scheffler@bayer.com
Janett Engels, Tel. +49 175 30 92 346, janett.engels@bayer.com

Restaurant

July 11, 2018 - 18:00 CET

Two Buddhas
Julie-Wolfthorn-Straße 1
10115 Berlin
Website

The restaurant is located within walking distance to the hotel:

Accommodation

Hotel

Reservation and costs
Hotel rooms have been blocked from 10^th-12^thJuly 2018 at the Titanic Chaussee Berlin ****, rate 103€ per night (including breakfast) with booking comment “Target 2035”.

Please make your own hotel reservation. “Target 2035” should be typed as a comment to the booking at checkout.

http://www.titanic.com.tr/titanicchausseeberlin/default-en.html

Titanic Chaussee Berlin
Chausseestraße 30
10115 Berlin, Germany

Another alternative would be the TRYP Hotel Berlin Mitte****, which is right beside the Titanic.

https://www.melia.com/de/hotels/deutschland/berlin/berlin-mitte-hotel/index.html

Hotel Berlin Mitte
Chausseestraße 33
10115 Berlin, Germany

If you would like to choose a different hotel, please contact Cora Scholten for other suggestions.

The way from the hotels to Bayer premises:
Walking distance 15 minutes
Via Underground: U6 - from Naturkundemuseum - Direction Alt-Tegel - to Reinickendorfer Straße

The way from Bayer to the hotels:
Take the Underground U6 - from Reinickendorfer Straße - Direction Alt-Mariendorf - to Naturkundemuseum