SGC-UNC: Advancing Drug Discovery Through Open Collaboration

The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC-UNC) is a team of scientists dedicated to discovering and sharing selective, small molecule inhibitors of protein kinases. Their work aims to expand drug discovery across this important class of disease-relevant proteins and help speed the creation of new medicines for patients.

The UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill houses the first U.S. site of the SGC, a public-private target discovery consortium that catalyzes research in new areas of human biology and drug discovery. The SGC-UNC mission is to:

  • Coordinate precompetitive chemistry across the SGC sites at UNC, Oxford, UK and Campinas, Brazil to develop probes for protein kinases
  • Share the GlaxoSmithKline Published Kinase Inhibitor Set (PKIS) with academic investigators for testing in human disease-relevant assays
  • Synthesize high-quality chemical probes for understudied kinases and share them with the scientific community to support target discovery experiments
  • Promote open sharing of data through an easily accessible database
  • Provide scientific community outreach through conferences as well as through engagement with foundations, 
patients and academic institutions


- A public-private partnership to unlock the untargeted kinome. Nature Chemical Biology Read more 
- Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS) Curr. Top. Med. Chem. Read more
Open access chemical and clinical   probes to support drug discovery. Nature Chemical Biology Read more 
The promise and peril of chemical probes. Nat. Chem Biol. Read more 

Coming soon : "Targeting the untargeted kinome: the GSK published kinase inhibitor set." Nat. Biotechnol.

SGC UNC careers

There are currently no open vacancies with the SGC-UNC. Please check back periodically for opportunities which may arise or access SGC Careers main page.


UNC People

Tim Willson

Research Professor (UNC) - Chief Scientist (SGC)

Bill Zuercher

Research Associate Professor (UNC) - Principal Investigator . Target Validation (SGC)

Alison Axtman

Research Assistant Professor (UNC) - Principal Investigator (SGC)

Carrow Wells

Research Associate (UNC) - Principal Investigator (SGC)

David Drewry

Research Associate Professor (UNC) - Principal Investigator (SGC)

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