Andreas Krämer graduated with a diploma in Chemistry from the University of Freiburg in 2012. During his PhD thesis at the University of Darmstadt (2013-2017), he focused on structural studies of bacterial members of the histone deacetylase superfamily (HDAC). After completing his PhD, he joined the group led by Stefan Knapp at the SGC Frankfurt as a postdoc, where he was funded by the Wellcome Trust, working on the structure-based development of selective and potent CaMK1D kinase inhibitors for the treatment of highly aggressive subtypes of breast cancer. Afterwards he worked at the Frankfurt Cancer Institute (FCI) as a staff scientist where, among other things, he was responsible for developing a comprehensive screening platform for kinases. In the beginning of 2022, Andreas became a principal investigator and is responsible for running the X-ray crystallography facility unit. His current research interests focus primarily on the structural biology of kinases and E3 ligases.
Rak M, Menge A, Tesch R, Berger LM, Balourdas DI, Shevchenko E, Krämer A, Elson L, Berger BT, Abdi I, Wahl LM, Poso A, Kaiser A, Hanke T, Kronenberger T, Joerger AC, Müller S, Knapp S
J Med Chem. 2024-2-29 . .doi: 10.1021/acs.jmedchem.3c02217
PMID: 38422480Galal KA, Krämer A, Strickland BG, Smith JL, Dickmander RJ, Moorman NJ, Willson TM
Bioorg Med Chem Lett. 2024-1-8 . 99:129617 .doi: 10.1016/j.bmcl.2024.129617
PMID: 38199328Tredup C, Ndreshkjana B, Schneider NS, Tjaden A, Kemas AM, Youhanna S, Lauschke VM, Berger BT, Krämer A, Berger LM, Röhm S, Knapp S, Farin HF, Müller S
ACS Chem Biol. 2023-3-21 . .doi: 10.1021/acschembio.2c00877
PMID: 36944371Tang S, Garzon Sanz M, Smith O, Krämer A, Egbase D, Caton PW, Knapp S, Butterworth S
Acta Pharm Sin B. 2023-3-7 . 13(2):709-721 .doi: 10.1016/j.apsb.2022.07.016
PMID: 36873168Ong HW, Truong A, Kwarcinski F, de Silva C, Avalani K, Havener TM, Chirgwin M, Galal KA, Willis C, Krämer A, Liu S, Knapp S, Derbyshire ER, Zutshi R, Drewry DH
Eur J Med Chem. 2022-12-30 . 249:115043 .doi: 10.1016/j.ejmech.2022.115043
PMID: 36736152Schröder M, Leiendecker M, Grädler U, Braun J, Blum A, Wanior M, Berger BT, Krämer A, Müller S, Esdar C, Knapp S, Heinrich T
J Med Chem. 2022-12-14 . .doi: 10.1021/acs.jmedchem.2c01705
PMID: 36516476Amrhein JA, Berger LM, Tjaden A, Krämer A, Elson L, Tolvanen T, Martinez-Molina D, Kaiser A, Schubert-Zsilavecz M, Müller S, Knapp S, Hanke T
Int J Mol Sci. 2022-11-27 . 23(23): .doi: 10.3390/ijms232314834
PMID: 36499165Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T
J Med Chem. 2022-11-16 . .doi: 10.1021/acs.jmedchem.2c01041
PMID: 36384036Kurz CG, Preuss F, Tjaden A, Cusack M, Amrhein JA, Chatterjee D, Mathea S, Berger LM, Berger BT, Krämer A, Weller M, Weiss T, Müller S, Knapp S, Hanke T
J Med Chem. 2022-5-24 . .doi: 10.1021/acs.jmedchem.2c00173
PMID: 35608370Zhu WF, Krämer A, Knapp S, Proschak E, Hernandez-Olmos V
J Org Chem. 2022-2-18 . .doi: 10.1021/acs.joc.1c03057
PMID: 35179025