Welcome to SGC

Critical Assessment of Computational Hit-finding Experiments (CACHE)

Make a donation to support CACHE’s collaboration with scientists in Ukraine.

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

News & Outreach

Informing and engaging to transform drug discovery into an inclusive endeavour.

Latest Structures

COPB2: Human Coatomer subunit beta, WDR domain, in complex with covalent fragment OICR-6254

COPB2: Human Coatomer subunit beta, WDR domain

TRIP12: Human E3 ubiquitin-protein ligase TRIP12 isoform 2, WWE domain, in complex with ADP

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule OICR-6766

CARM1: Human histone-arginine methyltransferase CARM1 in complex with bi-substrate inhibitor MT556

PRMT9: Human protein arginine N-methyltransferase 9, methyltransferase domain, in complex with inhibitor MT221

SEC31A: Human protein transport protein Sec31A, WDR domain

CORO1C: Human Coronin-1C, WDR domain

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule CYCA-117-70

New Publications

High-content live-cell multiplex screen for chemogenomic compound annotation based on nuclear morphology.

STAR Protoc

Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease.

Cell Rep

The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use.

Nucleic Acids Res

Discovery of Hit Compounds for Methyl-lysine Reader Proteins from a Target Class DNA-Encoded Library.

SLAS Discov

PBRM1, SETD2 and BAP1 - the trinity of 3p in clear cell renal cell carcinoma.

Nat Rev Urol

Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation.

Proc Natl Acad Sci U S A

A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candidates.

Int J Mol Sci

Chemical Probes

MU1742 - Chemical probe for CK1δ and CK1ε protein kinases

16th October 2022

BAY-805 - Chemical probe for USP21

15th October 2022

MRK-952 - Chemical probe for NUDT5

15th October 2022

MRK-990 - Dual activity chemical probe for PRMT9 and PRMT5

15th October 2022

News from SGC

International Chemical Biology Society Annual Conference 2022

Posted on 16th September 2022

New federation aims to transform biology with protein tools spanning proteome by 2035

Posted on 3rd August 2022

A conversation on using chemical probes to study protein function in cells and organisms

Posted on 5th July 2022

Focus on...

Medicinal Chemistry at SGC

With the involvement of:

Paul Brennan
Medicinal Chemistry
Peter J. Brown
Epigenetic Chem Probes

SGC Careers

Open vacancies : 1

Postdoctoral Fellows in Structural Biology

SGC Careers page