Welcome to SGC

Open Lab Notebooks

Extreme Open Science Initiative: SGC scientists around the world are starting to post their lab notebook online in real time.

About

The SGC is a public-private partnership that supports the discovery of new medicines through open access research.

Reagents & Resources

Created, discovered and shared by the SGC without restriction on use: innovation for everyone.

People

A Global network of multi-talented and multi-cultural team of cross-disciplinary scientists: all committed to accelerate drug discovery.

Latest Structures

MLL3: Human lysine methyltransferase 2C, 6th PHD domain, in complex with H4 peptide
HUWE1: Human HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, WWE domain
SETD3: Human SET Domain-Containing Protein 3, methyltransferase domain, in complex with methylated β-actin peptide
PP-BRD12: Cryptosporidium parvum bromodomain containing protein 12 (cgd4_650), bromodomain, in complex with inhibitor BI-2536
RFXANK: Human regulatory factor X associated ankyrin containing protein, ankyrin repeat, in complex with a RFX7 peptide
SETD3: Human SET Domain-Containing Protein 3, methyltransferase domain, in complex with unmethylated β-actin peptide
FYN: Human FYN proto-oncogene, Src family tyrosine kinase, SH3 domain
all structures

New Publications

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.
Cancer Cell
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.
Nat Commun
Architecture of the native major royal jelly protein 1 oligomer.
Nat Commun
The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration.
Front Aging Neurosci
SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
EMBO Journal
Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.
Biochimie
full list

Chemical Probes

VinSpinIn - A chemical probe for the Spin family proteins
12th September 2018
TP-238 - A chemical probe for CECR2/BPTF bromodomains
5th September 2018
DDR-TRK-1 - A chemical probe for the DDR and TRK kinase
15th August 2018
BI-9321 - for NSD3
18th July 2018
show all

News from SGC

Open Science Probe Project launched
Posted on 9th May 2018
Conference announcement: BMP Signalling in Cancer II
Posted on 16th March 2018
ALS Reproducible Antibody Platform: Open Science to enable consistent data and accelerate reliable discoveries in Amyotrophic Lateral Sclerosis
Posted on 7th March 2018
more news
 

Focus on...

Fragment Based Screening at SGC
With the involvement of:

SGC Careers

Open vacancies : 3
SGC Oxford - Postdoctoral Scientist - Protein Biochemist
SGC Oxford - Research Technician – Molecular Biology (maternity cover)
SGC Oxford - Postdoctoral Scientist – Membrane Protein Structure and Function Group
SGC Careers page
 
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