Welcome to SGC

Critical Assessment of Computational Hit-finding Experiments (CACHE)

Make a donation to support CACHE’s collaboration with scientists in Ukraine.

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

SGC’s 20th Anniversary Symposium in Toronto

Join us to celebrate two decades of collaborative open science: past, present and future!

Latest Structures

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule OICR-8268

53BP1: Human TP53 binding protein tandem Tudor domain in complex with MFP-5956

53BP1: Human TP53 binding protein, tandem Tudor domain, in complex with compound MFP-5973

pfPKG: Plasmodium falciparum cGMP-dependent protein kinase PKG in complex with RY-1-165

EIF2A: Human eukaryotic translation initiation factor 2A, WDR domain

COPB2: Human Coatomer subunit beta, WDR domain, in complex with covalent fragment OICR-6254

COPB2: Human Coatomer subunit beta, WDR domain

TRIP12: Human E3 ubiquitin-protein ligase TRIP12 isoform 2, WWE domain, in complex with ADP

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule OICR-6766

New Publications

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.

Proc Natl Acad Sci U S A

Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.

J Med Chem

Development of a Potent Cyclic Peptide Inhibitor of the nNOS/PSD-95 Interaction.

J Med Chem

Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1.

Front Physiol

High-content live-cell multiplex screen for chemogenomic compound annotation based on nuclear morphology.

STAR Protoc

MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core.

J Med Chem

The future of chemical probes is diversity.

RSC Med Chem

Chemical Probes

MSC1186 -

23rd January 2023

CS640 -

13th January 2023

MU1742 - Chemical probe for CK1δ and CK1ε protein kinases

16th October 2022

BAY-805 - Chemical probe for USP21

15th October 2022

News from SGC

SGC 20th Anniversary Symposium

Posted on 9th January 2023

International Chemical Biology Society Annual Conference 2022

Posted on 16th September 2022

New federation aims to transform biology with protein tools spanning proteome by 2035

Posted on 3rd August 2022

A conversation on using chemical probes to study protein function in cells and organisms

Posted on 5th July 2022

Understanding antitumor activity opens new possibilities for future breast cancer treatments

Posted on 16th May 2022

SGC Careers

Open vacancies : 1

Postdoctoral Fellows in Structural Biology

SGC Careers page