Welcome to SGC

Critical Assessment of Computational Hit-finding Experiments (CACHE)

Make a donation to support CACHE’s collaboration with scientists in Ukraine.

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

News & Outreach

Informing and engaging to transform drug discovery into an inclusive endeavour.

Latest Structures

COPB2: Human Coatomer subunit beta, WDR domain, in complex with covalent fragment OICR-6254

COPB2: Human Coatomer subunit beta, WDR domain

TRIP12: Human E3 ubiquitin-protein ligase TRIP12 isoform 2, WWE domain, in complex with ADP

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule OICR-6766

CARM1: Human histone-arginine methyltransferase CARM1 in complex with bi-substrate inhibitor MT556

PRMT9: Human protein arginine N-methyltransferase 9, methyltransferase domain, in complex with inhibitor MT221

SEC31A: Human protein transport protein Sec31A, WDR domain

New Publications

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.

Biochim Biophys Acta Gene Regul Mech

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.

Nat Commun

A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3-d]pyrimidine Core.

ACS Med Chem Lett

Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors.

ACS Infect Dis

Binding adaptation of GS-441524 diversifies macro domains and downregulate SARS-CoV-2 de-MARylation capacity.

J Mol Biol

A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria.

ACS Infect Dis

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding.

Nat Rev Chem

Chemical Probes

MU1700 - Chemical probe for ALK1 and ALK2 protein kinases

28th February 2022

M4K2234 - Chemical probe for ALK1 and ALK2 protein kinases

28th February 2022

MSC2711186 - Chemical probe for SPRK family (SPRK1/2/3)

1st February 2022

SGC-UBD253 - Chemical probe for the ubiquitin binding domain of HDAC6.

28th January 2022

News from SGC

International Chemical Biology Society Annual Conference 2022

Posted on 16th September 2022

New federation aims to transform biology with protein tools spanning proteome by 2035

Posted on 3rd August 2022

A conversation on using chemical probes to study protein function in cells and organisms

Posted on 5th July 2022

Focus on...

Protein Methyltransferases at SGC

With the involvement of:

Matthieu Schapira
Research Informatics
Masoud Vedadi
Molecular Biophysics
Peter Brown
Epigenetic Chemical Probes
Susanne Graslund
Biotechnology

SGC Careers

Open vacancies : 1

Faculty Position at the University of Toronto and University Health Network

SGC Careers page