Welcome to SGC

Critical Assessment of Computational Hit-finding Experiments (CACHE)

Make a donation to support CACHE’s collaboration with scientists in Ukraine.

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

News & Outreach

Informing and engaging to transform drug discovery into an inclusive endeavour.

Latest Structures

TRIP12: Human E3 ubiquitin-protein ligase TRIP12 isoform 2, WWE domain, in complex with ADP

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule OICR-6766

CARM1: Human histone-arginine methyltransferase CARM1 in complex with bi-substrate inhibitor MT556

PRMT9: Human protein arginine N-methyltransferase 9, methyltransferase domain, in complex with inhibitor MT221

SEC31A: Human protein transport protein Sec31A, WDR domain

CORO1C: Human Coronin-1C, WDR domain

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule CYCA-117-70

New Publications

Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase.

PLoS ONE

Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PLoS ONE

Actin/myosin-based gliding motility in apicomplexan parasites.

Subcell. Biochem.

Comparative structural analysis of lipid binding START domains.

PLoS ONE

Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7.

PLoS ONE

Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles.

J Med Chem

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.

Nat Chem Biol

Chemical Probes

MU1700 - Chemical probe for ALK1 and ALK2 protein kinases

28th February 2022

M4K2234 - Chemical probe for ALK1 and ALK2 protein kinases

28th February 2022

MSC2711186 - Chemical probe for SPRK family (SPRK1/2/3)

1st February 2022

SGC-UBD253 - Chemical probe for the ubiquitin binding domain of HDAC6.

28th January 2022

News from SGC

Understanding antitumor activity opens new possibilities for future breast cancer treatments

Posted on 16th May 2022

Stopping Pandemics Before They Start: Lessons Learned From SARS-CoV-2

Posted on 10th March 2022

Structural Genomics Consortium Welcomes New Members - Bristol Myers Squibb, Genentech and Janssen

Posted on 8th March 2022

Focus on...

Medicinal Chemistry at SGC

With the involvement of:

Paul Brennan
Medicinal Chemistry
Peter J. Brown
Epigenetic Chem Probes

SGC Careers

Open vacancies : 1

Postdoc Research Associate at SGC-UNC

SGC Careers page