Welcome to SGC

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

New Open-AD Drug Discovery Center

SGC and collaborators to create open research tools for Alzheimer’s disease research funded by National Institute on Aging

Discovery of a chemical probe for PRDM9

A collaboration between MSD and the SGC has resulted in the discovery of MRK-740, a potent inhibitor of PRDM9

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Latest Structures

PRMT9: Human protein arginine N-methyltransferase 9, methyltransferase domain, in complex with inhibitor MT556

PAFAH1B1: Human platelet-activating factor acetylhydrolase IB subunit beta, WDR domain

TMPRSS2: Human Transmembrane protease serine 2, SRCR and serine protease domains, in complex with Nafamostat

RBBP7: Human histone-binding protein RBBP7

PPP1R10: Serine/threonine-protein phosphatase 1 regulatory subunit 10, PPP1R10, N-terminal TFIIS domain, fused to Myc Homology Box 0

WHSC1: Human Histone-lysine N-methyltransferase NSD2, first PWWP domain, in complex with MRT10241866a

BRD1: Human Bromodomain-containing protein 1, PWWP domain, in complex with DNA

New Publications

Assessing reversible and irreversible binding effects of kinase covalent inhibitors through ADP-Glo assays.

STAR Protoc

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.

J Med Chem

A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells.

Cell Chem Biol

Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.

Mol Ther

Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1.

J Biol Chem

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.

Nat Commun

Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells.

J Vis Exp

Chemical Probes

MRIA9 -

9th August 2021

Homer -

28th July 2021

SGC-SMARCA-BRDVIII - A Chemical Probe for SMARCA2/4 and PB1(5)

22nd December 2020

NR162 - A chemical probe for CASK

1st September 2020

News from SGC

Promising new approach to stop growth of brain cancer cells

Posted on 12th February 2021

Cheryl Arrowsmith of SGC-Toronto elected a Fellow of the Royal Society of Canada

Posted on 10th September 2020

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

Posted on 1st September 2020

Focus on...

Research Informatics at SGC

With the involvement of:

Matthieu Schapira
Research Informatics
Brian Marsden
Research Informatics

SGC Careers

Open vacancies : 1

Research Funding and Administrative Assistant

SGC Careers page