Welcome to SGC

Open Lab Notebooks

Extreme Open Science Initiative: SGC scientists around the world are starting to post their lab notebook online in real time.

About

The SGC is a public-private partnership that supports the discovery of new medicines through open access research.

Reagents & Resources

Created, discovered and shared by the SGC without restriction on use: innovation for everyone.

People

A Global network of multi-talented and multi-cultural team of cross-disciplinary scientists: all committed to accelerate drug discovery.

Latest Structures

MLL3: Human lysine methyltransferase 2C, 6th PHD domain, in complex with H4 peptide
HUWE1: Human HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, WWE domain
SETD3: Human SET Domain-Containing Protein 3, methyltransferase domain, in complex with methylated β-actin peptide
PP-BRD12: Cryptosporidium parvum bromodomain containing protein 12 (cgd4_650), bromodomain, in complex with inhibitor BI-2536
RFXANK: Human regulatory factor X associated ankyrin containing protein, ankyrin repeat, in complex with a RFX7 peptide
SETD3: Human SET Domain-Containing Protein 3, methyltransferase domain, in complex with unmethylated β-actin peptide
FYN: Human FYN proto-oncogene, Src family tyrosine kinase, SH3 domain
all structures

New Publications

Interactome rewiring following pharmacological targeting of BET bromodomains
Molecular Cell
Guiding COMPASS: Dpy-30 Positions SET1/MLL Epigenetic Signaling.
Structure
Arginine does not rescue p.Q188R mutation deleterious effect in classic galactosemia.
Orphanet Journal of Rare Diseases
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
Journal of Medicinal Chemistry
Allosteric Modulation of Binding Specificity by Alternative Packing of Protein Cores.
J. Mol. Biol.
Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Nucleic Acids Res.
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Angewandte Chemie International Edition
full list

Chemical Probes

VinSpinIn - A chemical probe for the Spin family proteins
12th September 2018
TP-238 - A chemical probe for CECR2/BPTF bromodomains
5th September 2018
DDR-TRK-1 - A chemical probe for the DDR and TRK kinase
15th August 2018
BI-9321 - for NSD3
18th July 2018
show all

News from SGC

List of Highly Cited Researchers released - Stefan Knapp from SGC Frankfurt and Cheryl H....
Posted on 3rd December 2018
Open Science Probe Project launched
Posted on 9th May 2018
Conference announcement: BMP Signalling in Cancer II
Posted on 16th March 2018
more news
 

Focus on...

Ubiquitin Biology at SGC
With the involvement of:

SGC Careers

Open vacancies : 5
SGC Oxford - Postdoctoral Scientist - Integral Membrane Protein Group 1
SGC Toronto - Postdoctoral Position in Cell and Chemical Biology
SGC Toronto - Postdoctoral Fellow
SGC Oxford - Laboratory Manager

Pages

SGC Careers page
 
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