Welcome to SGC

Open Lab Notebooks

Extreme Open Science Initiative: SGC scientists around the world are starting to post their lab notebook online in real time.

About

The SGC is a public-private partnership that supports the discovery of new medicines through open access research.

Reagents & Resources

Created, discovered and shared by the SGC without restriction on use: innovation for everyone.

People

A Global network of multi-talented and multi-cultural team of cross-disciplinary scientists: all committed to accelerate drug discovery.

Latest Structures

MLL3: Human lysine methyltransferase 2C, 6th PHD domain, in complex with H4 peptide
HUWE1: Human HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, WWE domain
SETD3: Human SET Domain-Containing Protein 3, methyltransferase domain, in complex with methylated β-actin peptide
PP-BRD12: Cryptosporidium parvum bromodomain containing protein 12 (cgd4_650), bromodomain, in complex with inhibitor BI-2536
RFXANK: Human regulatory factor X associated ankyrin containing protein, ankyrin repeat, in complex with a RFX7 peptide
SETD3: Human SET Domain-Containing Protein 3, methyltransferase domain, in complex with unmethylated β-actin peptide
FYN: Human FYN proto-oncogene, Src family tyrosine kinase, SH3 domain
all structures

New Publications

Identification of a cellularly active SIRT6 allosteric activator.
Nat. Chem. Biol.
Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9.
Slas Discovery
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis.
Nature
Characterization of inv(3) cell line OCI-AML-20 with stroma dependent CD34 expression.
Exp. Hematol.
Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells.
J. Autoimmun.
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.
Cancer Cell
Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Angewandte Chemie International Edition
full list

Chemical Probes

VinSpinIn - A chemical probe for the Spin family proteins
12th September 2018
TP-238 - A chemical probe for CECR2/BPTF bromodomains
5th September 2018
DDR-TRK-1 - A chemical probe for the DDR and TRK kinase
15th August 2018
BI-9321 - for NSD3
18th July 2018
show all

News from SGC

Open Science Probe Project launched
Posted on 9th May 2018
Conference announcement: BMP Signalling in Cancer II
Posted on 16th March 2018
ALS Reproducible Antibody Platform: Open Science to enable consistent data and accelerate reliable discoveries in Amyotrophic Lateral Sclerosis
Posted on 7th March 2018
more news
 

Focus on...

Screening of Small Molecules against Human Protein Kinases at SGC
With the involvement of:

SGC Careers

Open vacancies : 1
SGC Oxford - Post-Doctoral Scientist - Protein Crystallography and Fragment-based Discovery
SGC Careers page
 
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