Welcome to SGC

The Biomachine: Proteins in Praxis

An exhibition of arts by the Arts University of Bournemouth and the SGC. Radcliffe Science Library, 27th March 2019 - 15th June 2019.

EMBO course

High-throughput protein production and crystallization.

10 – 19 June 2019  Didcot, United Kingdom

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Research Highlight

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Latest Structures

BDF2: Tripanosoma cruzi TcCLB.506553.20, bromodomain
MET12SCA: Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, in complex with longer 3' overhang DNA
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, cross-linked to DNA abasic site
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, in complex with 3' overhang DNA
DYRK1AA: Crystal structure of DYRK1A complexed with FC162 inhibitor
FAM83BA: PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000622a
all structures

New Publications

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.
Nat Commun
Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Proc. Natl. Acad. Sci. U.S.A.
AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation.
Oncogene
Organizational innovation for developing new medicines that target aging and age-related conditions.
Journals of Gerontology, Series A
Design and characterization of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.
J. Biol. Chem.
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).
Journal of Medicinal Chemistry
Structural insights into SETD3-mediated histidine methylation on β-actin.
Elife
full list

Chemical Probes

NVS-BPTF-1 - A chemical probe for BPTF
19th February 2019
VinSpinIn - A chemical probe for the Spin family proteins
12th September 2018
TP-238 - A chemical probe for CECR2/BPTF bromodomains
5th September 2018
DDR-TRK-1 - A chemical probe for the DDR and TRK kinase
15th August 2018
show all

News from SGC

Life Sciences Entrepreneur Seminar
Posted on 20th March 2019
FOP Friends and FOP France renewed partnership with SGC Oxford
Posted on 13th February 2019
Life Sciences Entrepreneur Seminar
Posted on 11th February 2019
more news
 

Focus on...

Fragment Based Screening at SGC
With the involvement of:

SGC Careers

Open vacancies : 4
SGC Oxford - Postdoctoral Research Scientist in Structure-based Drug Design
SGC Oxford - Postdoctoral Research Scientist - Structural Biology in Metabolic Diseases
SGC Oxford - Team Leader XChem
SGC Unicamp - Postdoctoral Research Associate
SGC Careers page
 
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