Welcome to SGC

The Biomachine: Proteins in Praxis

An exhibition of arts by the Arts University of Bournemouth and the SGC. Radcliffe Science Library, 27th March 2019 - 15th June 2019.

EMBO course

High-throughput protein production and crystallization.

10 – 19 June 2019  Didcot, United Kingdom

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Research Highlight

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Latest Structures

BDF2: Tripanosoma cruzi TcCLB.506553.20, bromodomain
MET12SCA: Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain
CLK3A: Crystal structure of CLK3 in complex with TP003
CLK1A: CLK1 Kinase domain with bound imidazopyridin inhibitor TP003
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, in complex with longer 3' overhang DNA
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, cross-linked to DNA abasic site
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, in complex with 3' overhang DNA
all structures

New Publications

Structure and function of eTudor domain containing TDRD proteins.
Crit. Rev. Biochem. Mol. Biol.
Discovery of selective activators of PRC2 mutant EED-I363M.
Sci Rep
A chemical toolbox for the study of bromodomains and epigenetic signaling.
Nat Commun
Structural analyses reveal that MBD3 is a methylated-CG binder.
FEBS J.
Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.
Nucleic Acids Res.
Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function.
Biochemistry
Identification of the 2-Benzoxazol-2-yl-phenol Scaffold as New Hit for JMJD3 Inhibition.
ACS Medicinal Chemistry Letters
full list

Chemical Probes

VN339 - A chemical probe for CLK kinases
8th May 2019
T3-CLK - A chemical probe for CLK kinases
2nd May 2019
TP-008 - A chemical probe for activin receptor-like kinase (ALK4 and ALK5)
2nd May 2019
NVS-BPTF-1 - A chemical probe for BPTF
19th February 2019
show all

News from SGC

New treatment could become first ever targeted therapy designed for ‘untreatable’ childhood brain...
Posted on 10th May 2019
Life Sciences Entrepreneur Seminar
Posted on 20th March 2019
FOP Friends and FOP France renewed partnership with SGC Oxford
Posted on 13th February 2019
more news
 

Focus on...

Protein Methyltransferases at SGC
With the involvement of:

SGC Careers

Open vacancies : 3
SGC Oxford - Research Assistant - Cellular Drug Screening Assays
SGC Oxford - Research Assistant - Membrane Proteins
SGC Oxford - Software and Database Engineer
SGC Careers page
 
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