Welcome to SGC

Open Lab Notebooks

Extreme Open Science Initiative: SGC scientists around the world are starting to post their lab notebook online in real time.

About

The SGC is a public-private partnership that supports the discovery of new medicines through open access research.

Reagents & Resources

Created, discovered and shared by the SGC without restriction on use: innovation for everyone.

People

A Global network of multi-talented and multi-cultural team of cross-disciplinary scientists: all committed to accelerate drug discovery.

Latest Structures

USP05: Human ubiquitin specific peptidase 5, second ZnF domain, in complex with inhibitor DAT180
USP05: Human ubiquitin specific peptidase 5, second ZnF domain, in complex with inhibitor DAT201
CARM1: Human coactivator associated arginine methyltransferase 1, methyltransferase domain, in complex with inhibitor (R)-SKI-72
LOC149281: Human Alpha N-terminal protein methyltransferase 1B (a.k.a NTM1B), methyltransferase domain, in complex with SPKRI peptide substrate
MBD1: Human methyl-CpG binding domain protein 1, MBD domain, in complex with methylated DNA
MBD3: Human methyl-CpG binding domain protein 3, MBD domain, in complex with methylated CpG DNA
CARM1: Human coactivator associated arginine methyltransferase 1, methyltransferase domain, in complex with inhibitor (S)-SKI-72
all structures

New Publications

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.
Nat Commun
Architecture of the native major royal jelly protein 1 oligomer.
Nat Commun
The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration.
Front Aging Neurosci
SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
EMBO Journal
Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.
Biochimie
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
ACS Med Chem Lett
full list

Chemical Probes

VinSpinIn - A chemical probe for the Spin family proteins
12th September 2018
TP-238 - A chemical probe for CECR2/BPTF bromodomains
5th September 2018
DDR-TRK-1 - A chemical probe for the DDR and TRK kinase
15th August 2018
BI-9321 - for NSD3
18th July 2018
show all

News from SGC

Open Science Probe Project launched
Posted on 9th May 2018
Conference announcement: BMP Signalling in Cancer II
Posted on 16th March 2018
ALS Reproducible Antibody Platform: Open Science to enable consistent data and accelerate reliable discoveries in Amyotrophic Lateral Sclerosis
Posted on 7th March 2018
more news
 

Focus on...

Demethylases at SGC
With the involvement of:

SGC Careers

Open vacancies : 2
SGC Oxford - Laboratory Technician - Chemistry Biology (Protein Expression and Purification)
SGC Oxford - Postdoctoral Scientist - Protein Crystallography and Fragment-based Discovery
SGC Careers page
 
glqxz9283 sfy39587stf02 mnesdcuix8
sfy39587stf03