Welcome to SGC

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

Discovery of a chemical probe for PRDM9

A collaboration between MSD and the SGC has resulted in the discovery of MRK-740, a potent inhibitor of PRDM9

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Research Highlight

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Latest Structures

PRMT9: Human protein arginine N-methyltransferase 9, methyltransferase domain, in complex with inhibitor MT221

SEC31A: Human protein transport protein Sec31A, WDR domain

CORO1C: Human Coronin-1C, WDR domain

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule CYCA-117-70

GID4: Human glucose-induced degradation protein 4 homolog, substrate binding domain, in complex with chemical probe PFI-7

GID4: Human glucose-induced degradation protein 4 homolog, substrate binding domain, in complex with small molecule UBF9092

UTP15: Human U3 small nucleolar RNA-associated protein 15 homolog, WDR domain

New Publications

Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET.

STAR Protoc

Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space.

J Med Chem

Structural basis for the recognition of the S2, S5-phosphorylated RNA polymerase II CTD by the mRNA anti-terminator protein hSCAF4.

FEBS Lett

Exploration of Aberrant E3 Ligases Implicated in Alzheimer's Disease and Development of Chemical Tools to Modulate Their Function.

Front Cell Neurosci

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency.

Sci Adv

NUAK family kinase 2 is a novel therapeutic target for prostate cancer.

Mol Carcinog

Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.

J Med Chem

Chemical Probes

CK156 -

19th October 2021

PFI-7 -

30th September 2021

MRIA9 -

9th August 2021

Homer -

28th July 2021

News from SGC

Structural Genomics Consortium unveils LRRK2 genetic research initiative funded by The Michael J. Fox Foundation

Posted on 22nd November 2021

Structural Genomics Consortium Receives Grant for Women’s Health Discovery

Posted on 16th November 2021

Cyclica and Structural Genomics Consortium co-crystallize DCAF1

Posted on 11th November 2021

Focus on...

Growth Factor Signalling at SGC

With the involvement of:

Alex Bullock
Growth Factor Signalling and Ubiquitination

SGC Careers

There are currently no open vacancies with the SGC. Please check back periodically for opportunities which may arise in any of our sites.

SGC Careers page