Welcome to SGC

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Research Highlight

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Latest Structures

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule CYCA-117-70
GID4: Human glucose-induced degradation protein 4 homolog, substrate binding domain, in complex with chemical probe PFI-7
GID4: Human glucose-induced degradation protein 4 homolog, substrate binding domain, in complex with small molecule UBF9092
UTP15: Human U3 small nucleolar RNA-associated protein 15 homolog, WDR domain
PRMT9: Human protein arginine N-methyltransferase 9, methyltransferase domain, in complex with inhibitor MT556
PAFAH1B1: Human platelet-activating factor acetylhydrolase IB subunit beta, WDR domain
TMPRSS2: Human Transmembrane protease serine 2, SRCR and serine protease domains, in complex with Nafamostat
all structures

New Publications

Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET.
STAR Protoc
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
Proc Natl Acad Sci U S A
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Nat Chem Biol
Selectivity aspects of activity-based (chemical) probes.
Drug Discov Today
The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface.
Nucleic Acids Res
Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status.
J Biol Chem
Design of a Two-in-One Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
J Med Chem
full list

Chemical Probes

CK156 -
19th October 2021
PFI-7 -
30th September 2021
MRIA9 -
9th August 2021
Homer -
28th July 2021
show all

News from SGC

Structural Genomics Consortium unveils LRRK2 genetic research initiative funded by The Michael J. Fox Foundation
Posted on 22nd November 2021
Structural Genomics Consortium Receives Grant for Women’s Health Discovery
Posted on 16th November 2021
Cyclica and Structural Genomics Consortium co-crystallize DCAF1
Posted on 11th November 2021
more news
 

Focus on...

Bromodomains at SGC
With the involvement of:

SGC Careers

Open vacancies : 1
Director, SGC Women’s and Children’s Health Initiative
SGC Careers page
 
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