Welcome to SGC

Critical Assessment of Computational Hit-finding Experiments (CACHE)

Make a donation to support CACHE’s collaboration with scientists in Ukraine.

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

SGC’s 20th Anniversary Symposium in Sweden

Join us as we are continuing our celebration of two decades of collaborative open science in Europe!

Latest Structures

CBLB: Human E3 ubiquitin-protein ligase CBL-B, TKB domain, in complex with N-Aryl isoindolin-1-one

SETDB1: Human histone-lysine N-methyltransferase SETDB1, triple Tudor domain, in complex with compound UNC6535

CARM1: Human protein arginine methyltransferase CARM1, methyltransferase domain, in complex with compound YD1290

PRMT3: Human protein arginine N-methyltransferase 3, methyltransferase domain, in complex with compound II710

DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule OICR-8268

53BP1: Human TP53 binding protein tandem Tudor domain in complex with MFP-5956

53BP1: Human TP53 binding protein, tandem Tudor domain, in complex with compound MFP-5973

pfPKG: Plasmodium falciparum cGMP-dependent protein kinase PKG in complex with RY-1-165

EIF2A: Human eukaryotic translation initiation factor 2A, WDR domain

New Publications

Open drug discovery in Alzheimer's disease.

Alzheimers Dement (N Y)

Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1Îµ vs Casein Kinase 1Î´.

J Med Chem

A Small Step Toward Generalizability: Training a Machine Learning Scoring Function for Structure-Based Virtual Screening.

J Chem Inf Model

A novel BRET-based assay to investigate binding and residence times of unmodified ligands to the human lysosomal ion channel TRPML1 in intact cells.

J Biol Chem

Editorial: The next generation of tools and technologies for studying human neurons in a dish.

Front Cell Neurosci

NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b.

Biomol NMR Assign

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.

ACS Chem Neurosci

Chemical Probes

SGC-PI5P4Kγ/MYLK4-1 - A chemical probe for PI5P4K gamma and MYLK4.

8th May 2023

SGC-CK2-2 - A chemical probe for CK2/CSNK2.

3rd May 2023

MSC1186 - A chemical probe for the SRPK family.

23rd January 2023

CS640 - A chemical probe for CAMK1D.

13th January 2023

News from SGC

SGC’s Donated Chemical Probes Program: Driving Drug Discovery and Target Biology

Posted on 31st May 2023

Join our global network with a Mitacs program

Posted on 24th May 2023

Structural Genomics Consortium at UNC receives $1.5 million grant to help find possible new treatment options for patients with ALS.

Posted on 10th May 2023

Structural Genomics Consortium to lead AI-assisted Drug Discovery Initiative within the University of Toronto’s Acceleration Consortium

Posted on 2nd May 2023

SGC 20 TH ANNIVERSARY SYMPOSIUM RECAP

Posted on 27th March 2023

SGC Careers

There are currently no open vacancies with the SGC. Please check back periodically for opportunities which may arise in any of our sites.

SGC Careers page