Welcome to SGC

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

Discovery of a chemical probe for PRDM9

A collaboration between MSD and the SGC has resulted in the discovery of MRK-740, a potent inhibitor of PRDM9

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Research Highlight

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Latest Structures

PRMT9: Human protein arginine N-methyltransferase 9, methyltransferase domain, in complex with inhibitor MT556

PAFAH1B1: Human platelet-activating factor acetylhydrolase IB subunit beta, WDR domain

TMPRSS2: Human Transmembrane protease serine 2, SRCR and serine protease domains, in complex with Nafamostat

RBBP7: Human histone-binding protein RBBP7

PPP1R10: Serine/threonine-protein phosphatase 1 regulatory subunit 10, PPP1R10, N-terminal TFIIS domain, fused to Myc Homology Box 0

WHSC1: Human Histone-lysine N-methyltransferase NSD2, first PWWP domain, in complex with MRT10241866a

BRD1: Human Bromodomain-containing protein 1, PWWP domain, in complex with DNA

New Publications

Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET.

STAR Protoc

Design and Development of a Chemical Probe for Pseudokinase Ca2+/calmodulin-Dependent Ser/Thr Kinase.

J Med Chem

Characterizing the role of the dark kinome in neurodegenerative disease - A mini review.

Biochim Biophys Acta Gen Subj

Assessing reversible and irreversible binding effects of kinase covalent inhibitors through ADP-Glo assays.

STAR Protoc

Novel quaternary structures of the human prion protein globular domain.

Biochimie

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.

J Med Chem

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.

J Med Chem

Chemical Probes

PFI-7 -

30th September 2021

MRIA9 -

9th August 2021

Homer -

28th July 2021

SGC-SMARCA-BRDVIII - A Chemical Probe for SMARCA2/4 and PB1(5)

22nd December 2020

News from SGC

New look for Target 2035

Posted on 7th October 2021

Promising new approach to stop growth of brain cancer cells

Posted on 12th February 2021

Cheryl Arrowsmith of SGC-Toronto elected a Fellow of the Royal Society of Canada

Posted on 10th September 2020

Focus on...

Medicinal Chemistry at SGC

With the involvement of:

Paul Brennan
Medicinal Chemistry
Peter J. Brown
Epigenetic Chem Probes

SGC Careers

Open vacancies : 3

Director, SGC Women’s and Children’s Health Initiative

Postdoctoral Position – Limited Term

Research Technician - Cell Culture

SGC Careers page