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Open Lab Notebooks

Extreme Open Science Initiative: SGC scientists around the world are starting to post their lab notebook online in real time.

About

The SGC is a public-private partnership that supports the discovery of new medicines through open access research.

Reagents & Resources

Created, discovered and shared by the SGC without restriction on use: innovation for everyone.

People

A Global network of multi-talented and multi-cultural team of cross-disciplinary scientists: all committed to accelerate drug discovery.

Latest Structures

USP05: Human ubiquitin specific peptidase 5, second ZnF domain, in complex with inhibitor DAT180
USP05: Human ubiquitin specific peptidase 5, second ZnF domain, in complex with inhibitor DAT201
CARM1: Human coactivator associated arginine methyltransferase 1, methyltransferase domain, in complex with inhibitor (R)-SKI-72
LOC149281: Human Alpha N-terminal protein methyltransferase 1B (a.k.a NTM1B), methyltransferase domain, in complex with SPKRI peptide substrate
MBD1: Human methyl-CpG binding domain protein 1, MBD domain, in complex with methylated DNA
MBD3: Human methyl-CpG binding domain protein 3, MBD domain, in complex with methylated CpG DNA
CARM1: Human coactivator associated arginine methyltransferase 1, methyltransferase domain, in complex with inhibitor (S)-SKI-72
all structures

New Publications

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.
Nat Commun
Architecture of the native major royal jelly protein 1 oligomer.
Nat Commun
The Combination of Human Urinary Kallidinogenase and Mild Hypothermia Protects Adult Rats Against Hypoxic-Ischemic Encephalopathy-Induced Injury by Promoting Angiogenesis and Regeneration.
Front Aging Neurosci
SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
EMBO Journal
Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.
Biochimie
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
ACS Med Chem Lett
full list

Chemical Probes

VinSpinIn - A chemical probe for the Spin family proteins
12th September 2018
TP-238 - A chemical probe for CECR2/BPTF bromodomains
5th September 2018
DDR-TRK-1 - A chemical probe for the DDR and TRK kinase
15th August 2018
BI-9321 - for NSD3
18th July 2018
show all

News from SGC

Open Science Probe Project launched
Posted on 9th May 2018
Conference announcement: BMP Signalling in Cancer II
Posted on 16th March 2018
ALS Reproducible Antibody Platform: Open Science to enable consistent data and accelerate reliable discoveries in Amyotrophic Lateral Sclerosis
Posted on 7th March 2018
more news
 

Focus on...

Histone Acetyltransferases (HAT) at SGC
With the involvement of:

SGC Careers

Open vacancies : 2
SGC Oxford - Laboratory Technician - Chemistry Biology (Protein Expression and Purification)
SGC Oxford - Postdoctoral Scientist - Protein Crystallography and Fragment-based Discovery
SGC Careers page
 
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