Welcome to SGC

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Research Highlight

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

About

The SGC is a public-private partnership that supports the discovery of new medicines through open access research.

Latest Structures

FAM83BA: PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000622a
ACVR1A: Crystal structure of the ACVR1 (ALK2) kinase in complex with a Quinazolinone based ALK2 inhibitor with a 5-methyl core.
MBTD1: Human MBT domain-containing protein 1, MBT repeat, in complex with EPC1 peptide
USP05: Human ubiquitin specific peptidase 5, second ZnF domain, in complex with inhibitor DAT194
PP-BRD3: Tripanosoma cruzi TcCLB.506755.120, bromodomain
PP-BRD3: Trypanosoma brucei BDF5 (Tb427tmp.01.5000), bromodomain, in complex with inhibitor PF-CBP1
PP-BRD18: Tripanosoma cruzi TcCLB.506553.20, bromodomain, in complex with bromosporine
all structures

New Publications

Ideation and implementation of an open science drug discovery business model - M4K Pharma.
Wellcome Open Res
Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?
Annals of the Rheumatic Diseases
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Nat Commun
Open laboratory notebooks: good for science, good for society, good for scientists
F1000Research
Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiency.
BBA - Molecular Basis of Disease
Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor.
International Journal of Medical Microbiology
Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun
full list

Chemical Probes

VinSpinIn - A chemical probe for the Spin family proteins
12th September 2018
TP-238 - A chemical probe for CECR2/BPTF bromodomains
5th September 2018
DDR-TRK-1 - A chemical probe for the DDR and TRK kinase
15th August 2018
BI-9321 - for NSD3
18th July 2018
show all

News from SGC

FOP Friends and FOP France renewed partnership with SGC Oxford
Posted on 13th February 2019
Life Sciences Entrepreneur Seminar
Posted on 11th February 2019
New potential treatment for leukemia discovered by OICR scientists draws major industry investment
Posted on 29th January 2019
more news
 

Focus on...

Metabolic Enzymes & Complexes at SGC
With the involvement of:

SGC Careers

Open vacancies : 5
SGC Oxford - Research Technician (maternity cover)
SGC Oxford - Software and Database Engineer
SGC Oxford - Postdoctoral Research Scientist - Structural Biology in Metabolic Diseases
SGC Oxford - Postdoctoral Scientist - Kinase Inhibitor Development

Pages

SGC Careers page
 
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