Welcome to SGC

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

New Open-AD Drug Discovery Center

SGC and collaborators to create open research tools for Alzheimer’s disease research funded by National Institute on Aging

Discovery of a chemical probe for PRDM9

A collaboration between MSD and the SGC has resulted in the discovery of MRK-740, a potent inhibitor of PRDM9

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Latest Structures

TMPRSS2: Human Transmembrane protease serine 2, SRCR and serine protease domains, in complex with Nafamostat

RBBP7: Human histone-binding protein RBBP7

PPP1R10: Serine/threonine-protein phosphatase 1 regulatory subunit 10, PPP1R10, N-terminal TFIIS domain, fused to Myc Homology Box 0

WHSC1: Human Histone-lysine N-methyltransferase NSD2, first PWWP domain, in complex with MRT10241866a

BRD1: Human Bromodomain-containing protein 1, PWWP domain, in complex with DNA

CORO6: Human Coronin-6, WDR domain

EED: Human Polycomb protein EED, WDR domain, in complex with Astemizole

New Publications

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy.

Oncogene

Hepatitis B virus resistance to tenofovir: fact or fiction? A systematic literature review and structural analysis of drug resistance mechanisms.

Wellcome Open Res

A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex.

SLAS Discov

Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.

ACS Med Chem Lett

Structures of chromatin modulators in complex with nucleosome.

Curr Opin Chem Biol

Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.

J Med Chem

Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells.

Oncol Lett

Chemical Probes

SGC-SMARCA-BRDVIII - A Chemical Probe for SMARCA2/4 and PB1(5)

22nd December 2020

NR162 - A chemical probe for CASK

1st September 2020

PFI-6 - A novel chemical probe for MLLT1/3

23rd June 2020

SGC-CK2-1 - A chemical probe for CK2

11th June 2020

News from SGC

Promising new approach to stop growth of brain cancer cells

Posted on 12th February 2021

Cheryl Arrowsmith of SGC-Toronto elected a Fellow of the Royal Society of Canada

Posted on 10th September 2020

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

Posted on 1st September 2020

Focus on...

Bromodomains at SGC

With the involvement of:

Panagis Fillipakopoulos
Epigenetics
Stefan Knapp
Epigenetics & Chem Biology
Susanne Muller-Knapp
Epigenetics & Cellular Biology
Paul Brennan
Medicinal Chemistry
Brian Marsden
Research Informatics

SGC Careers

Open vacancies : 1

Full-stack Web Developer

SGC Careers page