Welcome to SGC

EMBO course

High-throughput protein production and crystallization.

10 – 19 June 2019  Didcot, United Kingdom

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Research Highlight

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

About

The SGC is a public-private partnership that supports the discovery of new medicines through open access research.

Latest Structures

BDF2: Tripanosoma cruzi TcCLB.506553.20, bromodomain
MET12SCA: Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain
CLK3A: Crystal structure of CLK3 in complex with T3-CLK
CLK1A: CLK1 Kinase domain with bound imidazopyridin inhibitor T3-CLK
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, in complex with longer 3' overhang DNA
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, cross-linked to DNA abasic site
HMCES: Human 5-hydroxymethylcytosine binding ES cell specific, SRAP domain, in complex with 3' overhang DNA
all structures

New Publications

Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun
Targeting protein methylation: from chemical tools to precision medicines.
Cell. Mol. Life Sci.
The dynamic conformational landscape of the protein methyltransferase SETD8.
Elife
Structure and function of eTudor domain containing TDRD proteins.
Crit. Rev. Biochem. Mol. Biol.
Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
Mol. Cell
Discovery of selective activators of PRC2 mutant EED-I363M.
Sci Rep
A chemical toolbox for the study of bromodomains and epigenetic signaling.
Nat Commun
full list

Chemical Probes

VN339 - A chemical probe for CLK kinases
8th May 2019
T3-CLK - A chemical probe for CLK kinases
2nd May 2019
TP-008 - A chemical probe for activin receptor-like kinase (ALK4 and ALK5)
2nd May 2019
NVS-BPTF-1 - A chemical probe for BPTF
19th February 2019
show all

News from SGC

New treatment could become first ever targeted therapy designed for ‘untreatable’ childhood brain...
Posted on 10th May 2019
Life Sciences Entrepreneur Seminar
Posted on 20th March 2019
FOP Friends and FOP France renewed partnership with SGC Oxford
Posted on 13th February 2019
more news
 

Focus on...

Metabolic Enzymes & Complexes at SGC
With the involvement of:

SGC Careers

Open vacancies : 7
SGC Oxford - Laboratory Technician - Protein Structure and Function
SGC Oxford - Laboratory Manager - Maternity Cover
SGC Oxford - Team Leader - XChem
SGC Oxford - Research Assistant - Membrane Proteins

Pages

SGC Careers page
 
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