Welcome to SGC

The SGC embarks on a new project as part of the EUbOPEN Consortium

The consortium consists of 22 partners that will work together to develop high quality chemical tools

Rapidly Emerging Antiviral Drug Development Initiative (READDI)

Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics

New Open-AD Drug Discovery Center

SGC and collaborators to create open research tools for Alzheimer’s disease research funded by National Institute on Aging

Discovery of a chemical probe for PRDM9

A collaboration between MSD and the SGC has resulted in the discovery of MRK-740, a potent inhibitor of PRDM9

MTase Chemical Probe Toolbox

A collection of well-characterized chemical probes and related reagents for the study of methylation-mediated signaling.

Latest Structures

CORO6: Human Coronin-6, WDR domain

EED: Human Polycomb protein EED, WDR domain, in complex with Astemizole

WDR55: WD repeat-containing protein 55, WDR domain

KIF21A: Human Kinesin-like protein KIF21A, WDR domain

FEM1C: Human E3 ligase protein fem-1 homolog C, ankyrin repeat, in complex with peptide

SCAF4: Human SR-related and CTD-associated factor 4, CID domain, in complex with peptide S2,S5p-CTD

FEM1C: Human protein fem-1 homolog C, N-terminal ankyrin repeat

New Publications

Large-scale survey and database of high affinity ligands for peptide recognition modules.

Mol Syst Biol

Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron.

Nat Chem Biol

Identification of lysine isobutyrylation as a new histone modification mark.

Nucleic Acids Res

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Scientific Data

Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures

Communications Chemistry

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

British Journal of Cancer

Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system

EMBO Journal

Chemical Probes

SGC-SMARCA-BRDVIII - A Chemical Probe for SMARCA2/4 and PB1(5)

22nd December 2020

NR162 - A chemical probe for CASK

1st September 2020

PFI-6 - A novel chemical probe for MLLT1/3

23rd June 2020

SGC-CK2-1 - A chemical probe for CK2

11th June 2020

News from SGC

Cheryl Arrowsmith of SGC-Toronto elected a Fellow of the Royal Society of Canada

Posted on 10th September 2020

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

Posted on 1st September 2020

The Viral Interruption Medicines Initiative (VIMI): Open Science coalition in Canada to prevent future pandemics

Posted on 15th May 2020

Focus on...

Growth Factor Signalling at SGC

With the involvement of:

Alex Bullock
Growth Factor Signalling and Ubiquitination

SGC Careers

There are currently no open vacancies with the SGC. Please check back periodically for opportunities which may arise in any of our sites.

SGC Careers page