Welcome to SGC

Latest Structures

CBLB: Human E3 ubiquitin-protein ligase CBL-B, TKB domain, in complex with N-Aryl isoindolin-1-one
SETDB1: Human histone-lysine N-methyltransferase SETDB1, triple Tudor domain, in complex with compound UNC6535
CARM1: Human protein arginine methyltransferase CARM1, methyltransferase domain, in complex with compound YD1290
PRMT3: Human protein arginine N-methyltransferase 3, methyltransferase domain, in complex with compound II710
DCAF1: Human DDB1- and CUL4-associated factor 1, WDR domain, in complex with small molecule OICR-8268
53BP1: Human TP53 binding protein tandem Tudor domain in complex with MFP-5956
53BP1: Human TP53 binding protein, tandem Tudor domain, in complex with compound MFP-5973
pfPKG: Plasmodium falciparum cGMP-dependent protein kinase PKG in complex with RY-1-165
EIF2A: Human eukaryotic translation initiation factor 2A, WDR domain
all structures

New Publications

Open drug discovery in Alzheimer's disease.
Alzheimers Dement (N Y)
Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ.
J Med Chem
A Small Step Toward Generalizability: Training a Machine Learning Scoring Function for Structure-Based Virtual Screening.
J Chem Inf Model
A novel BRET-based assay to investigate binding and residence times of unmodified ligands to the human lysosomal ion channel TRPML1 in intact cells.
J Biol Chem
Editorial: The next generation of tools and technologies for studying human neurons in a dish.
Front Cell Neurosci
NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b.
Biomol NMR Assign
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.
ACS Chem Neurosci
full list

Chemical Probes

SGC-PI5P4Kγ/MYLK4-1 - A chemical probe for PI5P4K gamma and MYLK4.
8th May 2023
SGC-CK2-2 - A chemical probe for CK2/CSNK2.
3rd May 2023
MSC1186 - A chemical probe for the SRPK family.
23rd January 2023
CS640 - A chemical probe for CAMK1D.
13th January 2023
show all

News from SGC

Join our global network with a Mitacs program
Posted on 24th May 2023
Structural Genomics Consortium at UNC receives $1.5 million grant to help find possible new treatment options for patients with ALS.
Posted on 10th May 2023
Structural Genomics Consortium to lead AI-assisted Drug Discovery Initiative within the University of Toronto’s Acceleration Consortium
Posted on 2nd May 2023
SGC 20 TH ANNIVERSARY SYMPOSIUM RECAP
Posted on 27th March 2023
SGC 20th Anniversary Symposium
Posted on 9th January 2023
more news
 

SGC Careers

Open vacancies : 1
Postdoctoral Fellow in Cell and Molecular Biology
SGC Careers page
 
glqxz9283 sfy39587stf02 mnesdcuix8
sfy39587stf03