SGC Chemical Probes

The table below contains the entire collection of probes from SGC’s chemical probes program. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers. 

To acquire a sample, follow the links on the webpage of your desired chemical probe. For inquiries or requests related to chemical probes or libraries, please contact us at proberequests@thesgc.org.

Brochure_Chemical Probes (May 2024)

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Probe Name Protein Family Target protein Control name Probe structure Cellular Usage
LH168 WD40 repeat WDR5 LH222 1 µM
OICR-41103 WD40 repeat DCAF1 OICR-41103N 1 µM; not to exceed 5 µM
SGC-CDKL2/AAK1/BMP2K-1 Kinase CDKL2 CDKL2/AAK1/BMP2K -1N ≤1 µM
TP-061 Helicases Brr2 TP-061N 5 µM
SGC-UBD1031 UBD (ubiquitin binding domain) USP16/HDAC6 SGC-UBD1031N 10 µM
UNC8732 Methyl Lysine Binder NSD2 UNC8884 3 µM
OICR11029 Transcription factor BCL6 OICR11600 1 µM
PFI-8 YEATS YEATS PFI-8N 1 µM
JA310 Kinase MST3, MST4 JA262 < 1 µM
SGC-GSK3-1 Kinase GSK3 SGC-CDKL5/GSK3-1N 100 nM
SGC-CDKL5/GSK3 Kinase CDKL5, GSK3 SGC-CDKL5/GSK3-1N 100 nM
SGC-CAF382-1 Kinase CDKL5 SGC-CAF268-1N ≤ 100 nM
TH-257 Kinase LIMK1, LIMK2 TH-263 1 µM
JA397 Kinase CDK14-18 JA314 < 1 µM
SGC-PI5P4Kγ/MYLK4-1 Kinase PI5P4K gamma, MYLK4 SGC-PI5P4Kγ/MYLK4-1N 100 nM
SGC-CK2-2 Kinase CK2/CSNK2 SGK-CK2-2N 1 µM
LIJTF500025 Kinase LIMK1, LIMK2 LIJTF500120 < 1 µM
MSC1186 Kinase SRPK MSC5360 < 1 µM
CS640 Kinase CAMK1 CS640s < 1 µM
MU1742 Kinase CK1δ, CK1ε MU2027 1 µM
BAY-805 USP (ubiquitin specific protease) USP21 BAY-728 1 µM
MRK-952 Hydrolase NUDT5 MRK-952-NC < 1 µM
MRK-990 Methyltransferase PRMT9, PRMT5 MRK-990-NC < 10 µM
SGC-PIKFYVE-1 Kinase PIKfyve SGC-PIKFYVE-1N 100 nM
MU1700 Kinase ALK1, ALK2 MU1700NC 1 µM
M4K2234 Kinase ALK1, ALK2 M4K2234NC 1 µM
SGC-UBD253 UBD (ubiquitin binding domain) HDAC6 SGC-UBD253N 3 µM
CK156 Kinase STK17A, DRAK1 CKJB71 5 µM
PFI-7 E3 ligase GID4 PFI-7N 1 µM
MRIA9 Kinase SIK1, SIK2, SIK3 MR7 10 µM
Homer WD40 repeat WDR5 nc_WDR5 and nc_VHL 1 µM
SGC-SMARCA-BRDVIII Bromodomains PB1(5), SMARCA2/4 SGC-BRDVIII-NC 10 µM
NR162 Kinase CASK NR187 10 µM
PFI-6 YEATS MLLT1, MLLT3 PFI-6N 1 µM
SGC-CK2-1 Kinase CSNK2A1, CSNK2A2 SGC-CK2-1N 100 nM
NVS-MLLT-1 YEATS MLLT1, MLLT3 NVS-MLLT-C 1 µM
SGC-STK17B-1 Kinase STK17B, DRAK2 SGC-STK17B-1N 1 µM
SGC-CLK-1 Kinase CLK1, CLK2, CLK4 SGC-CLK-1N 1 µM
SGC-CAMKK2-1 Kinase CAMKK1, CAMKK2 SGC-CAMKK2-1N 1 µM
PFI-5 Methyltransferase SMYD2 PFI-5N 1 µM
SGC6870 Methyltransferase PRMT6 SGC6870N 1 µM
UNC6934 Methyl Lysine Binder NSD2-PWWP1 UNC7145 1 µM
MU1210 Kinase CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 MU140 1 µM
NVS-BPTF-1 Bromodomains BPTF NVS-BPTF-C < 1 µM
VinSpinIn Spindlin domains Spin1 VinSpinIC 0.5 µM - 3 µM
TP-238 Bromodomains CECR2, BPTF TP-422 < 2 µM
DDR-TRK-1 Kinase DDR, TRK DDR-TRK-1N 5 µM
SKI-73 Methyltransferase CARM1 SKI-73N 1 µM
BI-9321 Methyl Lysine Binder NSD3 BI-9466 0.5 µM - 20 µM
MRK-740 Methyltransferase PRDM9 MRK-740-NC 3 µM
SGC3027 Methyltransferase PRMT7 SGC3027N 1 µM
SGC-GAK-1 Kinase GAK SGC-GAK-1N 1 µM
SGC-AAK1-1 Kinase AAK1, BMP2K, BIKE SGC-AAK1-1N 1 µM
BI01383298 Solute carriers SLC13A5 BI01372674 1 µM
L-Moses Bromodomains KAT2A, KAT2B D-Moses 1 µM
BAY-6035 Methyltransferase SMYD3 BAY-444 1 µM
GSK4027 Bromodomains KAT2A, KAT2B GSK4028 1 µM
FM-381 Kinase JAK3 FM-479 100 nM
BAY-850 Bromodomains ATAD2 BAY-460 1 µM
GSK8814 Bromodomains ATAD2, ATAD2B GSK8815 1 µM
GSK6853 Bromodomains BRPF1 GSK9311 < 1 µM
LLY-283 Methyltransferase PRMT5 LLY-284 1 µM
A-395 WD40 repeat EED A-395N 100 nM
NVS-PAK1-1 Kinase PAK1 NVS-PAK1-C 1 µM
TP-472 Bromodomains BRD9, BRD7 TP-472N 1 µM
TP-064 Methyltransferase CARM1 TP-064N 1 µM
BAY-299 Bromodomains TAF1, BRD1 BAY-364 1 µM
GSK864 Dehydrogenase IDH1 GSK990 1 µM
MS023 Methyltransferase PRMT1, PRMT3, CARM1, PRMT6, PRMT8 MS094 1 µM
A-196 Methyltransferase SUV420H1, SUV420H2 SGC2043 1 µM
GSK591 Methyltransferase PRMT5 SGC2096 1 µM
MS049 Methyltransferase CARM1, PRMT6 MS049N 1 µM
NVS-CECR2-1 Bromodomains CECR2 NVS-CECR2-C 1 µM
I-BRD9 Bromodomains BRD9 1 µM
BI-9564 Bromodomains BRD9, BRD7 1 µM
BAY-598 Methyltransferase SMYD2 BAY-369 1 µM
GSK484 Arginine deiminases PAD4 GSK106 1 µM
GSK2801 Bromodomains BAZ2A, BAZ2B GSK8573 1 µM
LP99 Bromodomains BRD9, BRD7 2S,3R-enantiomer 1 µM
NI-57 Bromodomains BRPF1, BRD1, BRPF3 1 µM
PFI-4 Bromodomains BRPF1 1 µM
OF-1 Bromodomains BRPF1, BRD1, BRPF3 <5 µM
SGC707 Methyltransferase PRMT3 XY1 1 µM
BAZ2-ICR Bromodomains BAZ2A, BAZ2B 1 µM
OICR-9429 WD40 repeat WDR5 OICR-0547 1 µM
GSK-LSD1 Lysine Demethylase KDM1A/LSD1 100 nM
LLY-507 (multiple off-targets) Methyltransferase SMYD2 SGC705 1 µM
PFI-3 Bromodomains SMARCA2, PBRM1, SMARCA4 PFI-3oMet 1 µM
A-366 Methyltransferase EHMT1/GLP, EHMT2/G9a 1 µM
UNC1999 Methyltransferase EZH2 UNC2400 1 µM
(R)-PFI-2 Methyltransferase SETD7 (S)-PFI-2 1 µM
SGC-CBP30 Bromodomains CREBBP, EP300 BDOIA513 1 µM
I-CBP112 Bromodomains CREBBP, EP300 1 µM
Bromosporine (BSP) Bromodomains pan-Bromodomain 5 µM
UNC1215 Methyl Lysine Binder L3MBTL3 UNC1079 1 µM
UNC0642 Methyltransferase EHMT2/G9a, EHMT1/GLP 1 µM
GSK343 Methyltransferase EZH2 1 µM
GSK-J1 Lysine Demethylase KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B GSK-J2 (GSK-J5) 100 nM
SGC0946 Methyltransferase DOT1L SGC0649 1 µM
IOX2 2OG PHD2 1 µM
IOX1 2OG Pan-KDM 1 µM - 20 µM
PFI-1 Bromodomains BRD2, BRD3, BRD4, BRDT 1 µM
UNC0638 Methyltransferase EHMT2/G9a, EHMT1/GLP UNC0737 ≤ 1 µM
(+)-JQ1 Bromodomains BRD2, BRD3, BRD4, BRDT (-)-JQ1 1 µM
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