David Drewry is a renowned leader in the medicinal chemistry of protein kinases and is one of the principal architects of the research strategy at the SGC-UNC to build an open and collaborative research network to promote target discovery. He previously enjoyed more than 24 years as a medicinal chemist with GlaxoSmithKline and legacy companies, where he led teams working across the preclinical spectrum of drug discovery. His research interests include the art and science of medicinal chemistry, kinase inhibitor design, utilization of annotated sets of kinase inhibitors to build understanding of signaling networks and precompetitive chemical biology to facilitate target identification. After earning a Bachelor’s of Science degree, cum laude, in chemistry from Yale University, Drewry earned his doctorate at the University of California, Berkeley in the laboratory of Paul Bartlett, working on the design, synthesis and mechanistic studies of zinc protease inhibitors. Drewry is currently the head of chemistry at Meryx Pharmaceuticals, a biotech startup focused on small-molecule inhibitors of Mer kinase that was a spinoff from the UNC Eshelman School of Pharmacy. Drewry enjoys running, reading and relaxing with his family at local restaurants, the movie theater or in the kitchen playing board games.
Ong HW, de Silva C, Avalani K, Kwarcinski F, Mansfield CR, Chirgwin M, Truong A, Derbyshire ER, Zutshi R, Drewry DH
ACS Med Chem Lett. 2023-12-14 . 14(12):1774-1784 .doi: 10.1021/acsmedchemlett.3c00354
PMID: 38116430Tiek D, Wells CI, Schröder M, Song X, Alamillo-Ferrer C, Goenka A, Iglesia R, Lu M, Hu B, Kwarcinski F, Sintha P, de Silva C, Hossain MA, Picado A, Zuercher W, Zutshi R, Knapp S, Riggins RB, Cheng SY, Drewry DH
Curr Res Chem Biol. 2023-11-27 . 3: .doi: 10.1016/j.crchbi.2023.100045
PMID: 38009092Klug DM, Tse EG, Silva DG, Cao Y, Charman SA, Chauhan J, Crighton E, Dichiara M, Drake C, Drewry D, da Silva Emery F, Ferrins L, Graves L, Hopkins E, Kresina TAC, Lorente-MacÃas Ã, Perry B, Phipps R, Quiroga B, Quotadamo A, Sabatino GN, Sama A, Schätzlein A, Simpson QJ, Steele J, Shanu-Wilson J, Sjö P, Stapleton P, Swain CJ, Vaideanu A, Xie H, Zuercher W, Todd MH
ACS Infect Dis. 2023-11-22 . .doi: 10.1021/acsinfecdis.3c00286
PMID: 37991879Bashore FM, Annor-Gyamfi J, Du Y, Katis V, Nwogbo F, Flax RG, Frye SV, Pearce KH, Fu H, Willson TM, Drewry DH, Axtman AD
J Med Chem. 2023-10-24 . .doi: 10.1021/acs.jmedchem.3c01277
PMID: 37874947Anderson B, Rosston P, Ong HW, Hossain MA, Davis-Gilbert ZW, Drewry DH
Biochem J. 2023-8-30 . 480(16):1331-1363 .doi: 10.1042/BCJ20220217
PMID: 37642371Wells CI, Drewry DH
Methods Mol Biol. 2023-8-10 . 2706:11-24 .doi: 10.1007/978-1-0716-3397-7_2
PMID: 37558938Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir S, Axtman AD
Elife. 2023-7-25 . 12: .doi: 10.7554/eLife.88206
PMID: 37490324Negoita F, Addinsall AB, Hellberg K, Bringas CF, Hafen PS, Sermersheim TJ, Agerholm M, Lewis CTA, Ahwazi D, Ling NXY, Larsen JK, Deshmukh AS, Hossain MA, Oakhill JS, Ochala J, Brault JJ, Sankar U, Drewry DH, Scott JW, Witczak CA, Sakamoto K
Mol Metab. 2023-6-26 . 101761 .doi: 10.1016/j.molmet.2023.101761
PMID: 37380024Nam J, Schirmer AU, Loh C, Drewry DH, Macias E
Cancers (Basel). 2023-5-18 . 15(10): .doi: 10.3390/cancers15102817
PMID: 37345153Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, Axtman AD
ACS Chem Neurosci. 2023-4-21 . .doi: 10.1021/acschemneuro.3c00135
PMID: 37084253