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Oxford
SGC Oxford - Research Assistant
Applications are invited for a highly motivated Research Assistant, to work on the structure and function of proteins linked to human disease within the Structural Genomics Consortium.
SGC Oxford - Research Associate - Crysalin Technology
THIS VACANCY IS FOR INTERNAL APPLICANTS ONLY
Applications are invited for a Research Associate in Crysalin Technology to work within the Protein Crystallography group at the Structural Genomic Consortium.
SGC Oxford - Postdoctoral Scientist, Target analysis and project coordinator
Applications are invited for a highly motivated Postdoctoral Research Scientist and Project Coordinator, to work on Target Analysis within the Structural Genomic Consortium (SGC).
SGC Oxford - Postdoctoral Scientist in Molecular Cell Biology
Applications are invited for a highly motivated Postdoctoral scientist in Molecular Cell Biology to work within the Structural Genomic Consortium (SGC).
SGC Oxford - Postdoctoral Scientist in Structural Biology
Applications are invited for a highly motivated Postdoctoral Scientist in Structural Biology to work within the Structural Genomic Consortium (SGC).
SGC Oxford - Academic Clinical Lecturer in Infectious Diseases and Medical Microbiology
SGC Oxford - Postdoctoral Scientist-Integral Membrane Proteins Group 1
We are seeking a Postdoctoral Scientist with membrane protein structural biology and electron microscopy experience to work as part of a collaboration between Professor Liz Carpenter’s group at the Structural Genomics Consortium in Oxford and the Structural Research Group of Boehringer Ingelheim in Biberach, Germany.
This position is funded by the Boehringer Ingelheim (BI) and will require the postholder to work 70% (183 days) from SGC labs in Oxford, UK and 30% (77 days) from the BI labs in Biberach, Germany.
Human Kelch-like protein 20 (KLHL20)
The BTB-Kelch protein KLHL20 is a hypoxia-induced CUL3-dependent E3 ligase linked to autophagy, Alzheimer’s disease and cancer. KLHL20 acts to terminate autophagy by promoting the ubiquitination and degradation of ULK1. KLHL20 is also reported as a top 20 biomarker for Alzheimer’s disease progression. Inhibition of KLHL20 may be neuroprotective by extending autophagy for the clearance of neurotoxic proteins aggregates. KLHL20 also promotes cancer through the ubiquitination and degradation of tumour suppressors including PML and DAPK1.
Human Stromal Antigen 1 (STAG1) Cohesin Subunit SA-1
Loss of function mutations in the cohesin subunit gene STAG2 are common in a variety of cancers (1). These cells become dependent on the paralogous cohesin subunit STAG1 (2-4). Mutants of STAG1 that disrupt the binding to the cohesin subunit RAD21 cannot complement the loss of STAG2. This TEP examines the druggability of STAG1 as a synthetic lethal strategy to treat stag2- cancers.
Human Kelch-like ECH Associated Protein 1 (KEAP1)
KEAP1 is a highly redox-sensitive member of the BTB-Kelch family that assembles with the CUL3 protein to form a Cullin-RING E3 ligase complex for the degradation of NRF2. Oxidative stress disables KEAP1 allowing NRF2 protein levels to accumulate for the transactivation of critical stress response genes. Consequently, the KEAP1-NRF2 system is a highly attractive target for the development of protein-protein interaction inhibitors that will stabilise NRF2 for therapeutic effect in conditions of neurodegeneration and inflammation.