Publications

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2020

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational design, synthesis, characterization, and crystallographic studies.

Mackie BD, Chen D, Dong G, Dong C, Parker H, Tooley C, Noinaj N, Min J, Huang R

J. Med. Chem.. doi: 10.1021/acs.jmedchem.0c00689

Publication date: July 20, 2020

PMID: 32689795

Naturally occurring cobalamin (B12) analogs can function as cofactors for human methylmalonyl-CoA mutase.

Sokolovskaya OM, Plessl T, Bailey H, Mackinnon S, Baumgartner MR, Yue WW, Froese DS, Taga ME

Biochimie. doi: 10.1016/j.biochi.2020.06.014

Publication date: July 10, 2020

PMID: 32659443

The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs.

Willems S, Kilu W, Ni X, Chaikuad A, Knapp S, Heering J, Merk D

Commun Chem. 3(1):85. doi: 10.1038/s42004-020-0331-0

Publication date: July 3, 2020

PMID: 36703399

Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.

Tauber M, Kreuz S, Lemak A, Mandal P, Yerkesh Z, Veluchamy A, Al-Gashgari B, Aljahani A, Cortés-Medina LV, Azhibek D, Fan L, Ong MS, Duan S, Houliston S, Arrowsmith CH, Fischle W

Nucleic Acids Res.. doi: 10.1093/nar/gkaa520

Publication date: July 1, 2020

PMID: 32609811

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism.

Bezerra GA, Foster WR, Bailey HJ, Hicks KG, Sauer SW, Dimitrov B, McCorvie TJ, Okun JG, Rutter J, Kölker S, Yue WW

IUCrJ. 7(Pt 4):693-706. doi: 10.1107/S205225252000696X

Publication date: July 1, 2020

PMID: 32695416

Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogs.

Chen D, Dong C, Dong G, Srinivasan K, Min J, Noinaj N, Huang R

J. Med. Chem.. doi: 10.1021/acs.jmedchem.0c00770

Publication date: July 1, 2020

PMID: 32605369

Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.

Zhang X, Zegar T, Weiser T, Hamdan FH, Berger BT, Lucas R, Balourdas DI, Ladigan S, Cheung PF, Liffers ST, Trajkovic-Arsic M, Scheffler B, Joerger AC, Hahn SA, Johnsen SA, Knapp S, Siveke JT

Int. J. Cancer. doi: 10.1002/ijc.33137

Publication date: June 29, 2020

PMID: 32599645

Identifying the target of an antiparasitic compound in Toxoplasma using thermal proteome profiling.

Herneisen AL, Sidik SM, Markus BM, Drewry DH, Zuercher WJ, Lourido S

ACS Chem. Biol.. doi: 10.1021/acschembio.0c00369

Publication date: June 29, 2020

PMID: 32597628

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.

Gütschow M, Eynde JJV, Jampilek J, Kang C, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, Muñoz-Torrero D

Molecules. 25(13):. doi: 10.3390/molecules25132968

Publication date: June 28, 2020

PMID: 32605268

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.

Chen Z, Wasney GA, Picaud S, Filippakopoulos P, Vedadi M, D'Angiolella V, Bullock AN

Open Biol. 10(6):200041. doi: 10.1098/rsob.200041

Publication date: June 24, 2020

PMID: 32574548

Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.

Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, Perttilä R, Preuss F, Suresh K, Stayrook SE, Tsutsui Y, Radhakrishnan R, Ungureanu D, Knapp S, Lemmon MA

Mol. Cell. doi: 10.1016/j.molcel.2020.06.018

Publication date: June 24, 2020

PMID: 32619402

Crowdsourcing drug discovery for pandemics.

Chodera J, Lee AA, London N, von Delft F

Nat Chem. doi: 10.1038/s41557-020-0496-2

Publication date: June 18, 2020

PMID: 32555379

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer.

Deblois G, Madani Tonekaboni SA, Grillo G, Martinez C, Kao YI, Tai F, Ettayebi I, Fortier AM, Savage P, Fedor AN, Liu X, Guilhamon P, Lima-Fernandes E, Murison A, Kuasne H, Ba-Alawi W, Cescon DW, Arrowsmith CH, De Carvalho DD, Haibe-Kains B, Locasale JW, Park M, Lupien M

Cancer Discov. doi: 10.1158/2159-8290.CD-19-1493

Publication date: June 16, 2020

PMID: 32546577

Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D.

Tong MHG, Jeeves M, Rajesh S, Ludwig C, Lenoir M, Kumar J, McClelland DM, Berditchevski F, Hubbard JA, Kenyon C, Butterworth S, Knapp S, Overduin M

Biomol NMR Assign. doi: 10.1007/s12104-020-09950-x

Publication date: June 13, 2020

PMID: 32535836

Recognition of nonproline N-terminal residues by the Pro/N-degron pathway.

Dong C, Chen SJ, Melnykov A, Weirich S, Sun K, Jeltsch A, Varshavsky A, Min J

Proc. Natl. Acad. Sci. U.S.A.. doi: 10.1073/pnas.2007085117

Publication date: June 8, 2020

PMID: 32513738

Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release.

Bailey HJ, Bezerra GA, Marcero JR, Padhi S, Foster WR, Rembeza E, Roy A, Bishop DF, Desnick RJ, Bulusu G, Dailey HA, Yue WW

Nat Commun. 11(1):2813. doi: 10.1038/s41467-020-16586-x

Publication date: June 4, 2020

PMID: 32499479

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution.

Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Böckler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrímsson E, Mazza D, Goding CR

Mol. Cell. doi: 10.1016/j.molcel.2020.05.025

Publication date: June 4, 2020

PMID: 32531202

Quantifying CDK inhibitor selectivity in live cells.

Wells CI, Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Ingold MR, Pickett JE, Drewry DH, Pugh KM, Schwinn MK, Hwang BB, Zegzouti H, Huber KVM, Cong M, Meisenheimer PL, Willson TM, Robers MB

Nat Commun. 11(1):2743. doi: 10.1038/s41467-020-16559-0

Publication date: June 2, 2020

PMID: 32488087

Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs).

Grozinsky-Glasberg S, Lines KE, Avniel-Polak S, Bountra C, Thakker RV

Endocr. Relat. Cancer. doi: 10.1530/ERC-20-0127

Publication date: June 1, 2020

PMID: 32590358

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M

Life Sci Alliance. 3(7):. doi: 10.26508/lsa.202000725

Publication date: May 30, 2020

PMID: 32467316

Bioisosteric Replacement of Arylamide-linked Spine Residues by N-Acylhydrazones and Selenophenes as Design Strategy to Novel Dibenzosuberone Derivatives as Type I½ p38 MAP Kinase Inhibitors.

Galvez Bulh Otilde Es Pedreira JUL, Nahidino P, Kudolo M, Pantsar T, Berger BT, Forster M, Knapp S, Laufer SA, Barreiro EJ

J. Med. Chem.. doi: 10.1021/acs.jmedchem.0c00508

Publication date: May 28, 2020

PMID: 32462866

Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases.

Krahn AI, Wells C, Drewry DH, Beitel LK, Durcan TM, Axtman AD

ACS Chem Neurosci. doi: 10.1021/acschemneuro.0c00176

Publication date: May 28, 2020

PMID: 32464049

HighVia-A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity.

Howarth A, Schröder M, Montenegro RC, Drewry DH, Heba S, Millar V, Müller S, Ebner DV

SLAS Discov. 2472555220923979. doi: 10.1177/2472555220923979

Publication date: May 27, 2020

PMID: 32458721

Structural Basis for the Binding Selectivity of Human CDY Chromodomains.

Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin S, Wang Y, Min J

Cell Chem Biol. doi: 10.1016/j.chembiol.2020.05.007

Publication date: May 26, 2020

PMID: 32470319

Discovery of highly selective inhibitors of calmodulin-dependent kinases that restore insulin sensitivity in the diet-induced obese in vivo mouse model.

Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini G, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaia V, Morgan J, Sorrell F, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers S, Cheetham S, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S

J. Med. Chem.. doi: 10.1021/acs.jmedchem.9b01803

Publication date: May 20, 2020

PMID: 32433887

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.

Michealraj KA, Kumar SA, Kim LJY, Cavalli FMG, Przelicki D, Wojcik JB, Delaidelli A, Bajic A, Saulnier O, MacLeod G, Vellanki RN, Vladoiu MC, Guilhamon P, Ong W, Lee JJY, Jiang Y, Holgado BL, Rasnitsyn A, Malik AA, Tsai R, Richman CM, Juraschka K, Haapasalo J, Wang EY, De Antonellis P, Suzuki H, Farooq H, Balin P, Kharas K, Van Ommeren R, Sirbu O, Rastan A, Krumholtz SL, Ly M, Ahmadi M, Deblois G, Srikanthan D, Luu B, Loukides J, Wu X, Garzia L, Ramaswamy V, Kanshin E, Sánchez-Osuna M, El-Hamamy I, Coutinho FJ, Prinos P, Singh S, Donovan LK, Daniels C, Schramek D, Tyers M, Weiss S, Stein LD, Lupien M, Wouters BG, Garcia BA, Arrowsmith CH, Sorensen PH, Angers S, Jabado N, Dirks PB, Mack SC, Agnihotri S, Rich JN, Taylor MD

Cell. doi: 10.1016/j.cell.2020.04.047

Publication date: May 20, 2020

PMID: 32445698

Mitochondrial uncoupling protein-dependent signaling in plant bioenergetics and stress response.

Barreto P, Miguez Couñago R, Arruda P

Mitochondrion. doi: 10.1016/j.mito.2020.05.001

Publication date: May 18, 2020

PMID: 32439620

Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer.

Baguña Torres J, Mosley M, Koustoulidou S, Hopkins S, Knapp S, Chaikuad A, Kondoh M, Tachibana K, Kersemans V, Cornelissen B

J. Nucl. Med.. doi: 10.2967/jnumed.120.243113

Publication date: May 15, 2020

PMID: 32414951

Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.

Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD

Eur J Med Chem. 200:112417. doi: 10.1016/j.ejmech.2020.112417

Publication date: May 15, 2020

PMID: 32505849

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.

Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, von Delft F, Dowson CG, Spring DR

Chem Sci. 11(39):10792-10801. doi: 10.1039/d0sc01232g

Publication date: May 14, 2020

PMID: 34094333

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.

Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H, Barsyte-Lovejoy D

Nat Commun. 11(1):2396. doi: 10.1038/s41467-020-16271-z

Publication date: May 14, 2020

PMID: 32409666

GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.

Foley AR, Zou Y, Dunford JE, Rooney J, Chandra G, Xiong H, Straub V, Voit T, Romero N, Donkervoort S, Hu Y, Markello T, Horn A, Qebibo L, Dastgir J, Meilleur K, Finkel RS, Fan Y, Mamchaoui K, Duguez S, Nelson I, Laporte J, Santi M, Malfatti E, Maisonobe T, Touraine P, Hirano M, Hughes I, Bushby K, Oppermann U, Böhm J, Jaiswal JK, Stojkovic T, Bönnemann CG

Ann. Neurol.. doi: 10.1002/ana.25772

Publication date: May 13, 2020

PMID: 32403198

Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.

Shen Y, Li F, Szewczyk MM, Halabelian L, Park KS, Chau I, Dong A, Zeng H, Chen H, Meng F, Barsyte-Lovejoy D, Arrowsmith CH, Brown P, Liu J, Vedadi M, Jin J

J. Med. Chem.. doi: 10.1021/acs.jmedchem.0c00406

Publication date: May 5, 2020

PMID: 32367723

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma.

Ensan D, Smil D, Zepeda-Velázquez CA, Panagopoulos D, Wong JF, Williams EP, Adamson R, Bullock AN, Kiyota T, Aman A, Roberts OG, Edwards AM, O'Meara JA, Isaac MB, Al-Awar R

J. Med. Chem.. doi: 10.1021/acs.jmedchem.0c00395

Publication date: May 5, 2020

PMID: 32369358

Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma.

Zhang X, Zegar T, Lucas A, Morrison-Smith C, Knox T, French CA, Knapp S, Müller S, Siveke JT

Oncogene. doi: 10.1038/s41388-020-1301-9

Publication date: May 4, 2020

PMID: 32366905

L-thyroxin and the non-classical thyroid hormone TETRAC are potent activators of PPARγ.

Gellrich L, Heitel P, Heering J, Kilu W, Pollinger J, Goebel T, Kahnt A, Arifi S, Pogoda W, Paulke A, Steinhilber D, Proschak E, Wurglics M, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Bischoff I, Fürst R, Merk D

J. Med. Chem.. doi: 10.1021/acs.jmedchem.9b02150

Publication date: May 1, 2020

PMID: 32356658

A lower X-gate in TASK channels traps inhibitors within the vestibule.

Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Müller T, Decher N, Carpenter EP

Nature. doi: 10.1038/s41586-020-2250-8

Publication date: April 29, 2020

PMID: 32499642

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.

Ketley A, Wojciechowska M, Ghidelli-Disse S, Bamborough P, Ghosh TK, Morato ML, Sedehizadeh S, Malik NA, Tang Z, Powalowska P, Tanner M, Billeter-Clark R, Trueman RC, Geiszler PC, Agostini A, Othman O, Bösche M, Bantscheff M, Rüdiger M, Mossakowska DE, Drewry DH, Zuercher WJ, Thornton CA, Drewes G, Uings I, Hayes CJ, Brook JD

Sci Transl Med. 12(541):. doi: 10.1126/scitranslmed.aaz2415

Publication date: April 29, 2020

PMID: 32350131

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.

Criqui M, Qamra A, Chu TW, Sharma M, Tsao J, Henry DA, Barsyte-Lovejoy D, Arrowsmith CH, Winegarden N, Lupien M, Harrington L

Elife. 9:. doi: 10.7554/eLife.47333

Publication date: April 16, 2020

PMID: 32297856

Crystal structure of DRIK1, a stress-responsive receptor-like pseudokinase, reveals the molecular basis for the absence of ATP binding.

Aquino B, da Silva VCH, Massirer KB, Arruda P

BMC Plant Biol.. 20(1):158. doi: 10.1186/s12870-020-2328-3

Publication date: April 15, 2020

PMID: 32293271

Importance of Quantifying Drug-Target Engagement in Cells.

Stefaniak J, Huber KVM

ACS Med Chem Lett. 11(4):403-406. doi: 10.1021/acsmedchemlett.9b00570

Publication date: April 9, 2020

PMID: 32292539

New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K).

Asquith CRM, Laitinen T, Wells CI, Tizzard GJ, Zuercher WJ

Molecules. 25(7):. doi: 10.3390/molecules25071697

Publication date: April 7, 2020

PMID: 32272798

The RESOLUTE consortium: unlocking SLC transporters for drug discovery.

Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, Goldmann U, Gürtl B, Klavins K, Klimek C, Lindinger S, Liñeiro-Retes E, Müller AC, Onstein S, Redinger G, Reil D, Sedlyarov V, Wolf G, Crawford M, Everley R, Hepworth D, Liu S, Noell S, Piotrowski M, Stanton R, Zhang H, Corallino S, Faedo A, Insidioso M, Maresca G, Redaelli L, Sassone F, Scarabottolo L, Stucchi M, Tarroni P, Tremolada S, Batoulis H, Becker A, Bender E, Chang YN, Ehrmann A, Müller-Fahrnow A, Pütter V, Zindel D, Hamilton B, Lenter M, Santacruz D, Viollet C, Whitehurst C, Johnsson K, Leippe P, Baumgarten B, Chang L, Ibig Y, Pfeifer M, Reinhardt J, Schönbett J, Selzer P, Seuwen K, Bettembourg C, Biton B, Czech J, de Foucauld H, Didier M, Licher T, Mikol V, Pommereau A, Puech F, Yaligara V, Edwards A, Bongers BJ, Heitman LH, IJzerman AP, Sijben HJ, van Westen GJP, Grixti J, Kell DB, Mughal F, Swainston N, Wright-Muelas M, Bohstedt T, Burgess-Brown N, Carpenter L, Dürr K, Hansen J, Scacioc A, Banci G, Colas C, Digles D, Ecker G, Füzi B, Gamsjäger V, Grandits M, Martini R, Troger F, Altermatt P, Doucerain C, Dürrenberger F, Manolova V, Steck AL, Sundström H, Wilhelm M, Steppan CM

Nat Rev Drug Discov. doi: 10.1038/d41573-020-00056-6

Publication date: April 7, 2020

PMID: 32265506

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design.

Curran PR, Radoux C, Smilova MD, Sykes R, Higueruelo A, Bradley A, Marsden BD, Spring DR, Blundell TL, Leach AR, Pitt WR, Cole JC

J Chem Inf Model. doi: 10.1021/acs.jcim.9b00996

Publication date: March 24, 2020

PMID: 32207937

Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.

Zhang H, Devoucoux M, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Côté J, Min J

Cell Rep. 30(12):3996-4002.e4. doi: 10.1016/j.celrep.2020.03.003

Publication date: March 24, 2020

PMID: 32209463

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.

Bauer MR, Krämer A, Settanni G, Jones RN, Ni X, Khan Tareque R, Fersht AR, Spencer J, Joerger AC

ACS Chem Biol. 15(3):657-668. doi: 10.1021/acschembio.9b00748

Publication date: March 20, 2020

PMID: 31990523

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.

Hanke T, Wong JF, Berger BT, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, Müller-Knapp S, Knapp S

ACS Chem. Biol.. doi: 10.1021/acschembio.0c00076

Publication date: March 16, 2020

PMID: 32176847

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.

Wells C, Couñago RM, Limas JC, Almeida TL, Cook JG, Drewry DH, Elkins JM, Gileadi O, Kapadia NR, Lorente-Macias A, Pickett JE, Riemen A, Ruela-de-Sousa RR, Willson TM, Zhang C, Zuercher WJ, Zutshi R, Axtman AD

ACS Med Chem Lett. 11(3):340-345. doi: 10.1021/acsmedchemlett.9b00399

Publication date: March 12, 2020

PMID: 32184967

HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells.

Shukla V, Halabelian L, Balagere S, Samaniego-Castruita D, Feldman DE, Arrowsmith CH, Rao A, Aravind L

Mol. Cell. 77(5):1154. doi: 10.1016/j.molcel.2020.02.008

Publication date: March 5, 2020

PMID: 32142687

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.

Cribbs AP, Terlecki-Zaniewicz S, Philpott M, Baardman J, Ahern D, Lindow M, Obad S, Oerum H, Sampey B, Mander PK, Penn H, Wordsworth P, Bowness P, de Winther M, Prinjha RK, Feldmann M, Oppermann U

Proc. Natl. Acad. Sci. U.S.A.. doi: 10.1073/pnas.1919893117

Publication date: March 2, 2020

PMID: 32123118

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