Publications | Structural Genomics Consortium

The structural basis of fatty acid elongation by the ELOVL elongases.

Nie L, Pascoa TC, Pike ACW, Bushell SR, Quigley A, Ruda GF, Chu A, Cole V, Speedman D, Moreira T, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Love JD, Brennan PE, Carpenter EP

Nat Struct Mol Biol. 28(6):512-520. doi: 10.1038/s41594-021-00605-6

Publication date: June 13, 2021

PMID: 34117479

Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.

Faudone G, Bischoff-Kont I, Rachor L, Willems S, Zhubi R, Kaiser A, Chaikuad A, Knapp S, Fürst R, Heering J, Merk D

J Med Chem. doi: 10.1021/acs.jmedchem.1c00733

Publication date: June 11, 2021

PMID: 34115934

Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.

Shrimp JH, Jing Y, Gamage ST, Nelson KM, Han J, Bryson KM, Montgomery DC, Thomas JM, Nance KD, Sharma S, Fox SD, Andressen T, Sinclair WR, Wu H, Allali-Hassani A, Senisterra G, Vedadi M, Lafontaine D, Dahlin JL, Marmorstein R, Walters MA, Meier JL

ACS Med Chem Lett. 12(6):887-892. doi: 10.1021/acsmedchemlett.0c00193

Publication date: June 10, 2021

PMID: 34141066

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.

Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS

Proc Natl Acad Sci U S A. 118(23):. doi: 10.1073/pnas.2100844118

Publication date: June 8, 2021

PMID: 34088839

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.

Yu D, Horton JR, Yang J, Hajian T, Vedadi M, Sagum CA, Bedford MT, Blumenthal RM, Zhang X, Cheng X

Nucleic Acids Res. doi: 10.1093/nar/gkab460

Publication date: June 4, 2021

PMID: 34086966

Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.

Tesch R, Rak M, Raab M, Berger LM, Kronenberger T, Joerger AC, Berger BT, Abdi I, Hanke T, Poso A, Strebhardt K, Sanhaji M, Knapp S

J Med Chem. doi: 10.1021/acs.jmedchem.0c02144

Publication date: June 4, 2021

PMID: 34086472

Controlling the Covalent Reactivity of a Kinase Inhibitor with Light.

Reynders M, Chaikuad A, Berger BT, Bauer K, Koch P, Laufer S, Knapp S, Trauner D

Angew Chem Int Ed Engl. doi: 10.1002/anie.202103767

Publication date: June 3, 2021

PMID: 34081840

Crowdsourced mapping of unexplored target space of kinase inhibitors.

Cichońska A, Ravikumar B, Allaway RJ, Wan F, Park S, Isayev O, Li S, Mason M, Lamb A, Tanoli Z, Jeon M, Kim S, Popova M, Capuzzi S, Zeng J, Dang K, Koytiger G, Kang J, Wells CI, Willson TM, Oprea TI, Schlessinger A, Drewry DH, Stolovitzky G, Wennerberg K, Guinney J, Aittokallio T

Nat Commun. 12(1):3307. doi: 10.1038/s41467-021-23165-1

Publication date: June 3, 2021

PMID: 34083538

Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.

Du D, Xu D, Zhu L, Stazi G, Zwergel C, Liu Y, Luo Z, Li Y, Zhang Y, Zhu K, Ding Y, Liu J, Fan S, Zhao K, Zhang N, Kong X, Jiang H, Chen K, Zhao K, Valente S, Min J, Duan W, Luo C

J Med Chem. doi: 10.1021/acs.jmedchem.0c02261

Publication date: June 2, 2021

PMID: 34077206

Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors.

Amrhein JA, Knapp S, Hanke T

J Med Chem. doi: 10.1021/acs.jmedchem.1c00217

Publication date: June 2, 2021

PMID: 34076436

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source.

Douangamath A, Powell A, Fearon D, Collins PM, Talon R, Krojer T, Skyner R, Brandao-Neto J, Dunnett L, Dias A, Aimon A, Pearce NM, Wild C, Gorrie-Stone T, von Delft F

J Vis Exp. doi: 10.3791/62414

Publication date: May 29, 2021

PMID: 34125095

BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation.

Vershinin Z, Feldman M, Werner T, Weil LE, Kublanovsky M, Abaev-Schneiderman E, Sklarz M, Lam EYN, Alasad K, Picaud S, Rotblat B, McAdam RA, Chalifa-Caspi V, Bantscheff M, Chapman T, Lewis HD, Filippakopoulos P, Dawson MA, Grandi P, Prinjha RK, Levy D

Sci Adv. 7(22):. doi: 10.1126/sciadv.abf5374

Publication date: May 28, 2021

PMID: 34039605

C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes.

Krishnathas GM, Strödke B, Mittmann L, Zech T, Berger LM, Reichel CA, Rösser S, Schmid T, Knapp S, Müller S, Bracher F, Fürst R, Bischoff-Kont I

FASEB J. 35(6):e21656. doi: 10.1096/fj.202100037R

Publication date: May 28, 2021

PMID: 34042211

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.

Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Abi Saad MJ, Alfano C, Almeida FCL, Alshamleh I, de Amorim GC, Anderson TK, Anobom CD, Anorma C, Bains JK, Bax A, Blackledge M, Blechar J, Böckmann A, Brigandat L, Bula A, Bütikofer M, Camacho-Zarco AR, Carlomagno T, Caruso IP, Ceylan B, Chaikuad A, Chu F, Cole L, Crosby MG, de Jesus V, Dhamotharan K, Felli IC, Ferner J, Fleischmann Y, Fogeron ML, Fourkiotis NK, Fuks C, Fürtig B, Gallo A, Gande SL, Gerez JA, Ghosh D, Gomes-Neto F, Gorbatyuk O, Guseva S, Hacker C, Häfner S, Hao B, Hargittay B, Henzler-Wildman K, Hoch JC, Hohmann KF, Hutchison MT, Jaudzems K, Jović K, Kaderli J, Kalniņš G, Kaņepe I, Kirchdoerfer RN, Kirkpatrick J, Knapp S, Krishnathas R, Kutz F, Zur Lage S, Lambertz R, Lang A, Laurents D, Lecoq L, Linhard V, Löhr F, Malki A, Bessa LM, Martin RW, Matzel T, Maurin D, McNutt SW, Mebus-Antunes NC, Meier BH, Meiser N, Mompeán M, Monaca E, Montserret R, Mariño Perez L, Moser C, Muhle-Goll C, Neves-Martins TC, Ni X, Norton-Baker B, Pierattelli R, Pontoriero L, Pustovalova Y, Ohlenschläger O, Orts J, Da Poian AT, Pyper DJ, Richter C, Riek R, Rienstra CM, Robertson A, Pinheiro AS, Sabbatella R, Salvi N, Saxena K, Schulte L, Schiavina M, Schwalbe H, Silber M, Almeida MDS, Sprague-Piercy MA, Spyroulias GA, Sreeramulu S, Tants JN, Tārs K, Torres F, Töws S, Treviño MÁ, Trucks S, Tsika AC, Varga K, Wang Y, Weber ME, Weigand JE, Wiedemann C, Wirmer-Bartoschek J, Wirtz Martin MA, Zehnder J, Hengesbach M, Schlundt A

Front Mol Biosci. 8:653148. doi: 10.3389/fmolb.2021.653148

Publication date: May 28, 2021

PMID: 34041264

Exploring protein hotspots by optimized fragment pharmacophores.

Bajusz D, Wade WS, Satała G, Bojarski AJ, Ilaš J, Ebner J, Grebien F, Papp H, Jakab F, Douangamath A, Fearon D, von Delft F, Schuller M, Ahel I, Wakefield A, Vajda S, Gerencsér J, Pallai P, Keserű GM

Nat Commun. 12(1):3201. doi: 10.1038/s41467-021-23443-y

Publication date: May 27, 2021

PMID: 34045440

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.

Conde J, Pumroy RA, Baker C, Rodrigues T, Guerreiro A, Sousa BB, Marques MC, de Almeida BP, Lee S, Leites EP, Picard D, Samanta A, Vaz SH, Sieglitz F, Langini M, Remke M, Roque R, Weiss T, Weller M, Liu Y, Han S, Corzana F, Morais VA, Faria CC, Carvalho T, Filippakopoulos P, Snijder B, Barbosa-Morais NL, Moiseenkova-Bell VY, Bernardes GJL

ACS Cent Sci. 7(5):868-881. doi: 10.1021/acscentsci.1c00070

Publication date: May 26, 2021

PMID: 34079902

Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

Chi G, Ebenhoch R, Man H, Tang H, Tremblay LE, Reggiano G, Qiu X, Bohstedt T, Liko I, Almeida FG, Garneau AP, Wang D, McKinley G, Moreau CP, Bountra KD, Abrusci P, Mukhopadhyay SMM, Fernandez-Cid A, Slimani S, Lavoie JL, Burgess-Brown NA, Tehan B, DiMaio F, Jazayeri A, Isenring P, Robinson CV, Dürr KL

EMBO J. e107294. doi: 10.15252/embj.2020107294

Publication date: May 25, 2021

PMID: 34031912

Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies.

Resetca D, MacDonald AS, Kenney TMG, Wei Y, Arrowsmith CH, Raught B, Penn LZ

Methods Mol Biol. 2318:45-67. doi: 10.1007/978-1-0716-1476-1_4

Publication date: May 22, 2021

PMID: 34019286

Editorial: Structural Studies of Protein Complexes in Signaling Pathways.

Prischi F, Filippakopoulos P

Front Mol Biosci. 8:641932. doi: 10.3389/fmolb.2021.641932

Publication date: May 18, 2021

PMID: 33996897

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.

Dölle A, Adhikari B, Krämer A, Weckesser J, Berner N, Berger LM, Diebold M, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Gebel J, Löhr F, Dötsch V, Eilers M, Heinzlmeir S, Kuster B, Sotriffer C, Wolf E, Knapp S

J Med Chem. doi: 10.1021/acs.jmedchem.1c00146

Publication date: May 13, 2021

PMID: 33980013

Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions.

Willems S, Gellrich L, Chaikuad A, Kluge S, Werz O, Heering J, Knapp S, Lorkowski S, Schubert-Zsilavecz M, Merk D

Cell Chem Biol. doi: 10.1016/j.chembiol.2021.04.019

Publication date: May 12, 2021

PMID: 33989565

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy.

Wanior M, Krämer A, Knapp S, Joerger AC

Oncogene. doi: 10.1038/s41388-021-01781-x

Publication date: May 3, 2021

PMID: 33941852

Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells.

Ma T, Hu C, Lal B, Zhou W, Ma Y, Ying M, Prinos P, Quiñones-Hinojosa A, Lim M, Laterra J, Li Y

Cancer Res. 81(9):2457-2469. doi: 10.1158/0008-5472.CAN-20-2489

Publication date: May 1, 2021

PMID: 33574085

Hepatitis B virus resistance to tenofovir: fact or fiction? A systematic literature review and structural analysis of drug resistance mechanisms.

Mokaya J, McNaughton AL, Bester PA, Goedhals D, Barnes E, Marsden BD, Matthews PC

Wellcome Open Res. 5:151. doi: 10.12688/wellcomeopenres.15992.1

Publication date: April 20, 2021

PMID: 33869791

A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex.

Khalili Yazdi A, Li F, Devkota K, Perveen S, Ghiabi P, Hajian T, Bolotokova A, Vedadi M

SLAS Discov. 24725552211008863. doi: 10.1177/24725552211008863

Publication date: April 19, 2021

PMID: 33874769

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.

Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT, Aimon A, Bennett JM, Brandao Neto J, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs MR, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, O'Brien P, Jura N, Ashworth A, Irwin JJ, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I

Sci Adv. 7(16):. doi: 10.1126/sciadv.abf8711

Publication date: April 16, 2021

PMID: 33853786

Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.

Ni X, Schröder M, Olieric V, Sharpe ME, Hernandez-Olmos V, Proschak E, Merk D, Knapp S, Chaikuad A

ACS Med Chem Lett. 12(4):603-609. doi: 10.1021/acsmedchemlett.0c00684

Publication date: April 8, 2021

PMID: 33850605

Structures of chromatin modulators in complex with nucleosome.

Min J, Liu K

Curr Opin Chem Biol. 63:105-114. doi: 10.1016/j.cbpa.2021.02.018

Publication date: April 3, 2021

PMID: 33823458

Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.

Schierle S, Chaikuad A, Lillich FF, Ni X, Woltersdorf S, Schallmayer E, Renelt B, Ronchetti R, Knapp S, Proschak E, Merk D

J Med Chem. doi: 10.1021/acs.jmedchem.1c00235

Publication date: April 1, 2021

PMID: 33793232

Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells.

Matossian MD, Elliott S, Rhodes LV, Martin EC, Hoang VT, Burks HE, Zuercher WJ, Drewry DH, Collins-Burow BM, Burow ME

Oncol Lett. 21(5):380. doi: 10.3892/ol.2021.12641

Publication date: March 30, 2021

PMID: 33777204

Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells.

Luparello C, Cruciata I, Joerger AC, Ocasio CA, Jones R, Tareque RK, Bagley MC, Spencer J, Walker M, Austin C, Ferrara T, D Oca P, Bellina R, Branni R, Caradonna F

Int J Mol Sci. 22(7):. doi: 10.3390/ijms22073410

Publication date: March 26, 2021

PMID: 33810274

Structural basis for RNA 3'-end recognition by the PIWIL2 PAZ domain.

Li Q, Dong A, Zhu Z, Zhang J, Li Y, Xu C

Biochem Biophys Res Commun. 553:187-190. doi: 10.1016/j.bbrc.2021.03.080

Publication date: March 25, 2021

PMID: 33774220

Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants.

Ni X, Londregan AT, Owen DR, Knapp S, Chaikuad A

ACS Chem Biol. doi: 10.1021/acschembio.0c00960

Publication date: March 21, 2021

PMID: 33749253

Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review.

Matossian MD, Wells CI, Zuercher WJ, Collins-Burow BM, Drewry DH, Burow ME

Curr Med Chem. doi: 10.2174/0929867328666210322101749

Publication date: March 21, 2021

PMID: 33749548

The Promise and Peril of Chemical Probe Negative Controls.

Lee J, Schapira M

ACS Chem Biol. doi: 10.1021/acschembio.1c00036

Publication date: March 21, 2021

PMID: 33745272

Protein arginine methylation: from enigmatic functions to therapeutic targeting.

Wu Q, Schapira M, Arrowsmith CH, Barsyte-Lovejoy D

Nat Rev Drug Discov. doi: 10.1038/s41573-021-00159-8

Publication date: March 19, 2021

PMID: 33742187

Structure and activation mechanism of the human liver-type glutaminase GLS2.

Ferreira IM, Edwin N Quesñay J, Bastos AC, Rodrigues CT, Vollmar M, Krojer T, Strain-Damerell C, Burgess-Brown NA, von Delft F, Yue WW, Dias SM, Ambrosio AL

Biochimie. doi: 10.1016/j.biochi.2021.03.009

Publication date: March 18, 2021

PMID: 33746066

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function.

Cribbs AP, Filippakopoulos P, Philpott M, Wells G, Penn H, Oerum H, Valge-Archer V, Feldmann M, Oppermann U

Front Immunol. 12:626255. doi: 10.3389/fimmu.2021.626255

Publication date: March 16, 2021

PMID: 33717143

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.

Mackinnon SR, Krojer T, Foster WR, Diaz-Saez L, Tang M, Huber KVM, von Delft F, Lai K, Brennan PE, Arruda Bezerra G, Yue WW

ACS Chem Biol. doi: 10.1021/acschembio.0c00498

Publication date: March 16, 2021

PMID: 33724769

Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy.

Di Rita A, Angelini DF, Maiorino T, Caputo V, Cascella R, Kumar M, Tiberti M, Lambrughi M, Wesch N, Löhr F, Dötsch V, Carinci M, D'Acunzo P, Chiurchiù V, Papaleo E, Rogov VV, Giardina E, Battistini L, Strappazzon F

Cell Death Differ. doi: 10.1038/s41418-021-00766-3

Publication date: March 15, 2021

PMID: 33723372

7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors.

Karatas M, Chaikuad A, Berger B, Kubbutat MHG, Totzke F, Knapp S, Kunick C

Molecules. 26(6):. doi: 10.3390/molecules26061611

Publication date: March 14, 2021

PMID: 33799460

Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.

Sugata K, Matsunaga Y, Yamashita Y, Nakatsugawa M, Guo T, Halabelian L, Ohashi Y, Saso K, Rahman MA, Anczurowski M, Wang CH, Murata K, Saijo H, Kagoya Y, Ly D, Burt BD, Butler MO, Mak TW, Hirano N

Nat Biotechnol. doi: 10.1038/s41587-021-00836-4

Publication date: March 1, 2021

PMID: 33649568

Reply to: Binding site for MDL-801 on SIRT6.

Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Shen H, Xu Y, Chen G, Zhang J

Nat Chem Biol. doi: 10.1038/s41589-021-00750-5

Publication date: March 1, 2021

PMID: 33649600

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.

Devkota K, Schapira M, Perveen S, Yazdi AK, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M

bioRxiv. doi: 10.1101/2021.02.19.424337

Publication date: February 19, 2021

PMID: 33619486

Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.

Němec V, Maier L, Berger BT, Chaikuad A, Drápela S, Souček K, Knapp S, Paruch K

Eur J Med Chem. 215:113299. doi: 10.1016/j.ejmech.2021.113299

Publication date: February 18, 2021

PMID: 33636538

A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.

Shen Y, Li F, Szewczyk MM, Halabelian L, Chau I, Eram MS, Dela Seña C, Park KS, Meng F, Chen H, Zeng H, McLeod D, Zepeda-Velázquez CA, Campbell RM, Mader MM, Watson BM, Schapira M, Arrowsmith CH, Al-Awar R, Barsyte-Lovejoy D, Kaniskan HÜ, Brown PJ, Vedadi M, Jin J

J Med Chem. doi: 10.1021/acs.jmedchem.0c02160

Publication date: February 16, 2021

PMID: 33591753

A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation.

Ostrop J, Zwiggelaar RT, Terndrup Pedersen M, Gerbe F, Bösl K, Lindholm HT, Díez-Sánchez A, Parmar N, Radetzki S, von Kries JP, Jay P, Jensen KB, Arrowsmith C, Oudhoff MJ

Front Cell Dev Biol. 8:618552. doi: 10.3389/fcell.2020.618552

Publication date: February 13, 2021

PMID: 33575256

PRMT5 inhibition disrupts splicing and stemness in glioblastoma.

Sachamitr P, Ho JC, Ciamponi FE, Ba-Alawi W, Coutinho FJ, Guilhamon P, Kushida MM, Cavalli FMG, Lee L, Rastegar N, Vu V, Sánchez-Osuna M, Coulombe-Huntington J, Kanshin E, Whetstone H, Durand M, Thibault P, Hart K, Mangos M, Veyhl J, Chen W, Tran N, Duong BC, Aman AM, Che X, Lan X, Whitley O, Zaslaver O, Barsyte-Lovejoy D, Richards LM, Restall I, Caudy A, Röst HL, Bonday ZQ, Bernstein M, Das S, Cusimano MD, Spears J, Bader GD, Pugh TJ, Tyers M, Lupien M, Haibe-Kains B, Artee Luchman H, Weiss S, Massirer KB, Prinos P, Arrowsmith CH, Dirks PB

Nat Commun. 12(1):979. doi: 10.1038/s41467-021-21204-5

Publication date: February 12, 2021

PMID: 33579912

Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.

Zhang M, Lei M, Qin S, Dong A, Yang A, Li Y, Loppnau P, Hughes TR, Min J, Liu Y

Biochim Biophys Acta Gene Regul Mech. 194688. doi: 10.1016/j.bbagrm.2021.194688

Publication date: February 5, 2021

PMID: 33556623

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.

Chen J, Sivan U, Tan SL, Lippo L, De Angelis J, Labella R, Singh A, Chatzis A, Cheuk S, Medhghalchi M, Gil J, Hollander G, Marsden BD, Williams R, Ramasamy SK, Kusumbe AP

Sci Adv. 7(6):. doi: 10.1126/sciadv.abd7819

Publication date: February 5, 2021

PMID: 33536212