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Oxford
Epigenetic regulation of lineage decisions and functional specialization in T cells
Professor Alf Hamann
Professor of Experimental Rheumatology & Senior Group Leader, German Arthritis Research Centre Berlin (DRFZ)
Basement Seminar Room, NDM Research Building (TDI), Old Road Campus
Thursday 26th June 2014
BAZ2-ICR
SGC Oxford wins Royal Society of Chemistry 2014 Rita and John Cornforth Award
The Group led by Professor Chas Bountra, Chief Scientist of SGC Oxford, has been awarded the Royal Society of Chemistry's Rita and John Cornforth Award 2014 for "... world leading collaborative research across the disciplines of structural biology, medicinal chemistry, chemical biology and enzymology towards understanding and exploiting the potential of epigenetics as a target family for future drug discovery".
SGC Oxford wins Royal Society of Chemistry 2014 Rita and John Cornforth Award
The Group led by Professor Chas Bountra, Chief Scientist of SGC Oxford, has been awarded the Royal Society of Chemistry's Rita and John Cornforth Award 2014 for "... world leading collaborative research across the disciplines of structural biology, medicinal chemistry, chemical biology and enzymology towards understanding and exploiting the potential of epigenetics as a target family for future drug discovery".
Targeting bromodomains: epigenetic readers of lysine acetylation
Inhibiting bromodomains - which are small interaction modules on proteins that assemble acetylation-dependent transcriptional regulatory complexes - could be a way to alter the expression of disease-promoting genes. In a Nature Reviews Drug Discovery article, the SGC highlights recent developments in the discovery of small-molecule bromodomain inhibitors and discuss how they might be used in cancer, inflammation and viral infection.
Epigenetic regulation of pain processing
Dr Sandrine Géranton
Senior Research Fellow, Department of Cell and Developmental Biology, University College London
Basement Seminar Room, NDM Research Building (TDI), Old Road Campus
Thursday 1st May 2014
GSK-LSD1
Structural Insights into SPLUNC1's Role in Cystic Fibrosis Lung Disease
Prof. Robert Tarran
Associate Professor, Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill
Basement Seminar Room, NDM Research Building (TDI), Old Road Campus
Monday 24th March 2014
In silico chemical biology for cancer drug discovery
Dr Bissan Al-Lazikani
Team Leader, Computational Biology and Chemogenomics, Division of Cancer Therapeutics, Institute of Cancer Research
Basement Seminar Room, NDM Research Building (TDI), Old Road Campus
Friday 14th March 2014
SGC and DiscoveRx® Corporation Publish Study Identifying Clinical Kinase Inhibitors that Potently Cross-React with Bromodomain Epigenetic Reader Proteins
The Structural Genomics Consortium (SGC) and DiscoveRx Corporation announced the publication of findings demonstrating that several clinical kinase inhibitors also potently inhibit diverse bromodomain epigenetic reader proteins. This study titled “Dual kinase-bromodomain inhibitors for rationally designed polypharmacology”, which appears on-line today in Nature Chemical Biology , suggests compelling new multi-targeting approaches for cancer therapy.
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