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Structural and Chemical Biology Bootcamp 2016

 

Date Topic

19-Jul

Tuesday

Med Chem career discussions :9.30am
Epigenetic short course: 10.30am
Epigenetics Short course: 1.30pm
Ethics in drug discovery: 3.30pm

20-Jul

Wednesday

Protein Production / Purification Workshop

21-Jul

Thursday

Crystallography Workshop

22-Jul

Friday

Leadership workshop

25-Jul

Monday

BioPhysics Workshop

26-Jul

Tuesday

Cell Biology Workshop

27-Jul

Wednesday

Medicinal Chemistry short course

28-Jul

Thursday

ChemNet Meeting

 

 

Courses and workshops 

 

An Introduction to Project management (by Procept Associates ltd)

  • Specific characteristics of a project
  • Common causes of failure
  • Project life cycle
  • Project charter
  • Measurable deliverables
  • Roles and responsibilities
  • Necessary skills
  • Implementing project management process

 

Structure based drug design and Molecular modelling (by Prof. Nicolas Moitessier, McGill University)

  • Docking
  • Predicting drug binding mode and potency
  • Virtual screening techniques
  • Predicting the sites of metabolism of drugs by liver enzymes 

 

Biophysics

This workshop aims to provide an opportunity for participants to learn how to implement differential scanning fluorimetry (DSF), radioactivity-based activity assays and peptide displacement methods.

 

Crystallography

Understanding concepts in crystallography is important, but for Structure-Based Drug Discovery, it is more important to have a good idea of where structures come from, how they are solved, and most important to have the ability to assess model quality.  SBDD requires analysis of positioning of each atom in the active site and each atom of a potential drug or ligand.  Therefore understanding how to interpret models and how far to trust crystallographic data will be emphasized over theory in this class.

 

Cell Biology

Protein Production & Purification - Access to high-quality protein is a prerequisite for crystallography, assay development and biophysical characterization. A major part of the resources at SGC is therefore spent in this area and we produce proteins, both through general high-throughput methods and one by one in complicated tailor-made processes. At the ChemNET boot camp we will run a workshop on protein production using the general high-throughput method to purify a set of ~12 proteins in parallel. The participants will get hands-on experience in using the LEX system for E.coli growth and the ÄKTA Xpress for parallel purification. We will also theoretically go over the cloning and expression screening methods and the eukaryotic expression systems used at the SGC.

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