Opher Gileadi

Opher Gileadi

SGC Karolinska

Gileadi

Opher Gileadi

Affiliations

Biography

Opher Gileadi obtained his PhD in Biochemistry at the Hebrew University and was then a postdoctoral fellow at Stanford University Medical School. Subsequently he led a research group at the Weizmann Institute of Science. From 2004-2021 he was both at SGC University of Oxford, first as head of the Biotechnology group, then as Principal Investigator of the Genome Integrity & Repair Group as well as Head of the SGC Kinase Chemical Biology Center at the State University of Campinas (UNICAMP). In 2021 Opher took at position as Executive Director, Protein Science and Structure at Exscientia, but re-join the SGC at Karolinska in 2023.

Opher leads the Protein Science team at SGC Karolinska, focussing on developing antibodies and target-enabling packages (TEPs) for under-investigated proteins of humans and pathogens.

2020

Screening and Production of Recombinant Human Proteins: Protein Production in Insect Cells.

Mahajan P, Strain-Damerell C, Mukhopadhyay S, Fernandez-Cid A, Gileadi O, Burgess-Brown NA

Methods Mol Biol. 2020-10-31 . 2199:67-94 .doi: 10.1007/978-1-0716-0892-0_5

PMID: 33125645

Screening and Production of Recombinant Human Proteins: Ligation-Independent Cloning.

Strain-Damerell C, Mahajan P, Fernandez-Cid A, Gileadi O, Burgess-Brown NA

Methods Mol Biol. 2020-10-31 . 2199:23-43 .doi: 10.1007/978-1-0716-0892-0_3

PMID: 33125643

Screening and Production of Recombinant Human Proteins: Protein Production in E. coli.

Burgess-Brown NA, Mahajan P, Strain-Damerell C, Fernandez-Cid A, Gileadi O, Gräslund S

Methods Mol Biol. 2020-10-31 . 2199:45-66 .doi: 10.1007/978-1-0716-0892-0_4

PMID: 33125644

RecQ helicases in DNA repair and cancer targets.

Newman JA, Gileadi O

Essays Biochem. 2020-10-26 . 64(5):819-830 .doi: 10.1042/EBC20200012

PMID: 33095241

The SNM1A DNA repair nuclease.

Baddock HT, Yosaatmadja Y, Newman JA, Schofield CJ, Gileadi O, McHugh PJ

DNA Repair (Amst.). 2020-7-31 . 95:102941 .doi: 10.1016/j.dnarep.2020.102941

PMID: 32866775

STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.

van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M

Life Sci Alliance. 2020-5-30 . 3(7): .doi: 10.26508/lsa.202000725

PMID: 32467316

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.

Wells C, Couñago RM, Limas JC, Almeida TL, Cook JG, Drewry DH, Elkins JM, Gileadi O, Kapadia NR, Lorente-Macias A, Pickett JE, Riemen A, Ruela-de-Sousa RR, Willson TM, Zhang C, Zuercher WJ, Zutshi R, Axtman AD

ACS Med Chem Lett. 2020-3-12 . 11(3):340-345 .doi: 10.1021/acsmedchemlett.9b00399

PMID: 32184967

2019

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.

Newman JA, Aitkenhead H, Gavard AE, Rota IA, Handel AE, Hollander GA, Gileadi O

J. Biol. Chem.. 2019-12-30 . .doi: 10.1074/jbc.RA119.010365

PMID: 31914405

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.

Profeta GS, Dos Reis CV, Santiago ADS, Godoi PHC, Fala AM, Wells CI, Sartori R, Salmazo APT, Ramos PZ, Massirer KB, Elkins JM, Drewry DH, Gileadi O, Couñago RM

Sci Rep. 2019-11-11 . 9(1):16452 .doi: 10.1038/s41598-019-52795-1

PMID: 31712618

The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity.

Righetto GL, Sriranganadane D, Halabelian L, Chiodi CG, Elkins JM, Massirer KB, Gileadi O, Menossi M, Couñago RM

Front Plant Sci. 2019-10-18 . 10:1105 .doi: 10.3389/fpls.2019.01105

PMID: 31620147