Opher Gileadi obtained his PhD in Biochemistry at the Hebrew University and was then a postdoctoral fellow at Stanford University Medical School. Subsequently he led a research group at the Weizmann Institute of Science. From 2004-2021 he was both at SGC University of Oxford, first as head of the Biotechnology group, then as Principal Investigator of the Genome Integrity & Repair Group as well as Head of the SGC Kinase Chemical Biology Center at the State University of Campinas (UNICAMP). In 2021 Opher took at position as Executive Director, Protein Science and Structure at Exscientia, but re-join the SGC at Karolinska in 2023.
Opher leads the Protein Science team at SGC Karolinska, focussing on developing antibodies and target-enabling packages (TEPs) for under-investigated proteins of humans and pathogens.
Twigg SR, Lloyd D, Jenkins D, Elçioglu NE, Cooper CD, Al-Sannaa N, Annagür A, Gillessen-Kaesbach G, Hüning I, Knight SJ, Goodship JA, Keavney BD, Beales PL, Gileadi O, McGowan SJ, Wilkie AO
Am. J. Hum. Genet.. 2012-11-2 . 91(5):897-905 .doi: 10.1016/j.ajhg.2012.08.027
PMID: 23063620Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergun DI, Gileadi O, Laue ED
J. Mol. Biol.. 2012-9-7 . 422(1):3-17 .doi: 10.1016/j.jmb.2012.04.031
PMID: 22575888Sengerová B, Allerston CK, Abu M, Lee SY, Hartley J, Kiakos K, Schofield CJ, Hartley JA, Gileadi O, McHugh PJ
J. Biol. Chem.. 2012-7-27 . 287(31):26254-67 .doi: 10.1074/jbc.M112.367243
PMID: 22692201Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A
J. Med. Chem.. 2012-7-26 . 55(14):6639-43 .doi: 10.1021/jm300677j
PMID: 22724510Keates T, Cooper CD, Savitsky P, Allerston CK, Phillips C, Hammarström M, Daga N, Berridge G, Mahajan P, Burgess-Brown NA, Müller S, Gräslund S, Gileadi O
N Biotechnol. 2012-6-15 . 29(5):515-25 .doi: 10.1016/j.nbt.2011.10.007
PMID: 22027370Krastanova I, Sannino V, Amenitsch H, Gileadi O, Pisani FM, Onesti S
J. Biol. Chem.. 2012-2-3 . 287(6):4121-8 .doi: 10.1074/jbc.M111.285395
PMID: 22147708Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U
J. Biol. Chem.. 2011-12-2 . 286(48):41616-25 .doi: 10.1074/jbc.M111.283689
PMID: 21914792Wang AT, Sengerová B, Cattell E, Inagawa T, Hartley JM, Kiakos K, Burgess-Brown NA, Swift LP, Enzlin JH, Schofield CJ, Gileadi O, Hartley JA, McHugh PJ
Genes Dev.. 2011-9-1 . 25(17):1859-70 .doi: 10.1101/gad.15699211
PMID: 21896658Chen D, Vollmar M, Rossi MN, Phillips C, Kraehenbuehl R, Slade D, Mehrotra PV, von Delft F, Crosthwaite SK, Gileadi O, Denu JM, Ahel I
J. Biol. Chem.. 2011-4-15 . 286(15):13261-71 .doi: 10.1074/jbc.M110.206771
PMID: 21257746Picaud S, Kavanagh KL, Yue WW, Lee WH, Muller-Knapp S, Gileadi O, Sacchettini J, Oppermann U
J. Inherit. Metab. Dis.. 2011-3-29 . 34(3):671-6 .doi: 10.1007/s10545-011-9294-8
PMID: 21445611