Matthieu Schapira, PhD is a Professor in the Department of Pharmacology and Toxicology, UofT, and is the head of computational chemistry, protein bioinformatics, and data management at the SGC-Toronto. He leads the CACHE initiative for benchmarking computational ‘hit finding’. Dr. Schapira is a recognized authority in the structural chemistry of drug target classes such as chromatin regulators, ubiquitylation pathways and WDR proteins, and has created popular online informatics resources for these targets such as Chromohub, Ubihub and ChemBioPort. He is interested in novel strategies to expand and ML tools to exploit the accessible chemistry space. His trainees have gone on to become important innovators in AI-driven drug discovery at Toronto-born biotechs such as Atomwise and Cyclica.
Newman JA, Douangamath A, Yadzani S, Yosaatmadja Y, Aimon A, Brandão-Neto J, Dunnett L, Gorrie-Stone T, Skyner R, Fearon D, Schapira M, von Delft F, Gileadi O
Nat Commun. 2021-8-11 . 12(1):4848 .doi: 10.1038/s41467-021-25166-6
PMID: 34381037Devkota K, Schapira M, Perveen S, Khalili Yazdi A, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M
SLAS Discov. 2021-7-1 . 24725552211026261 .doi: 10.1177/24725552211026261
PMID: 34192965Yazdani S, De Maio N, Ding Y, Shahani V, Goldman N, Schapira M
J Proteome Res. 2021-6-28 . .doi: 10.1021/acs.jproteome.1c00206
PMID: 34180678Lee J, Schapira M
ACS Chem Biol. 2021-3-21 . .doi: 10.1021/acschembio.1c00036
PMID: 33745272Wu Q, Schapira M, Arrowsmith CH, Barsyte-Lovejoy D
Nat Rev Drug Discov. 2021-3-19 . .doi: 10.1038/s41573-021-00159-8
PMID: 33742187Devkota K, Schapira M, Perveen S, Yazdi AK, Li F, Chau I, Ghiabi P, Hajian T, Loppnau P, Bolotokova A, Satchell KJF, Wang K, Li D, Liu J, Smil D, Luo M, Jin J, Fish PV, Brown PJ, Vedadi M
bioRxiv. 2021-2-19 . .doi: 10.1101/2021.02.19.424337
PMID: 33619486Shen Y, Li F, Szewczyk MM, Halabelian L, Chau I, Eram MS, Dela Seña C, Park KS, Meng F, Chen H, Zeng H, McLeod D, Zepeda-Velázquez CA, Campbell RM, Mader MM, Watson BM, Schapira M, Arrowsmith CH, Al-Awar R, Barsyte-Lovejoy D, Kaniskan HÜ, Brown PJ, Vedadi M, Jin J
J Med Chem. 2021-2-16 . .doi: 10.1021/acs.jmedchem.0c02160
PMID: 33591753Ferreira de Freitas R, Liu Y, Szewczyk MM, Mehta N, Li F, McLeod D, Zepeda-Velázquez C, Dilworth D, Hanley RP, Gibson E, Brown PJ, Al-Awar R, James LI, Arrowsmith CH, Barsyte-Lovejoy D, Min J, Vedadi M, Schapira M, Allali-Hassani A
J Med Chem. 2021-2-1 . .doi: 10.1021/acs.jmedchem.0c01768
PMID: 33522809Mielnik CA, Sugamori KS, Finlay DB, Thorpe HHA, Schapira M, Sivananthan N, Li CK, Lam VM, Harrington S, Abdelrahman MH, Trembleau LA, McIntyre Burnham W, Khokhar JY, Salahpour A, Ramsey AJ, Glass M, Greig IR, Ross RA
Neuropsychopharmacology. 2020-10-8 . .doi: 10.1038/s41386-020-00876-5
PMID: 33036015Bafeta A, Bobe J, Clucas J, Gonsalves PP, Gruson-Daniel C, Hudson KL, Klein A, Krishnakumar A, McCollister-Slipp A, Lindner AB, Misevic D, Naslund JA, Nebeker C, Nikolaidis A, Pasquetto I, Sanchez G, Schapira M, Scheininger T, Schoeller F, Sólon Heinsfeld A, Taddei F
PLoS Comput. Biol.. 2020-9-4 . 16(9):e1007846 .doi: 10.1371/journal.pcbi.1007846
PMID: 32881878