Matthieu Schapira, PhD is a Professor in the Department of Pharmacology and Toxicology, UofT, and is the head of computational chemistry, protein bioinformatics, and data management at the SGC-Toronto. He leads the CACHE initiative for benchmarking computational ‘hit finding’. Dr. Schapira is a recognized authority in the structural chemistry of drug target classes such as chromatin regulators, ubiquitylation pathways and WDR proteins, and has created popular online informatics resources for these targets such as Chromohub, Ubihub and ChemBioPort. He is interested in novel strategies to expand and ML tools to exploit the accessible chemistry space. His trainees have gone on to become important innovators in AI-driven drug discovery at Toronto-born biotechs such as Atomwise and Cyclica.
Gütschow M, Eynde JJV, Jampilek J, Kang C, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, Muñoz-Torrero D
Molecules. 2020-6-28 . 25(13): .doi: 10.3390/molecules25132968
PMID: 32605268Wang J, Yazdani S, Han A, Schapira M
Drug Discov. Today. 2020-2-19 . .doi: 10.1016/j.drudis.2020.02.006
PMID: 32084498Allali-Hassani A, Szewczyk MM, Ivanochko D, Organ SL, Bok J, Ho JSY, Gay FPH, Li F, Blazer L, Eram MS, Halabelian L, Dilworth D, Luciani GM, Lima-Fernandes E, Wu Q, Loppnau P, Palmer N, Talib SZA, Brown PJ, Schapira M, Kaldis P, O'Hagan RC, Guccione E, Barsyte-Lovejoy D, Arrowsmith CH, Sanders JM, Kattar SD, Bennett DJ, Nicholson B, Vedadi M
Nat Commun. 2019-12-17 . 10(1):5759 .doi: 10.1038/s41467-019-13652-x
PMID: 31848333Ferreira de Freitas R, Ivanochko D, Schapira M
Molecules. 2019-12-8 . 24(24): .doi: 10.3390/molecules24244492
PMID: 31817960Mann MK, Franzoni I, de Freitas RF, Tempel W, Houliston S, Smith L, Vedadi M, Arrowsmith CH, Harding RJ, Schapira M
J. Med. Chem.. 2019-10-30 . .doi: 10.1021/acs.jmedchem.9b00988
PMID: 31663737Schapira M, Calabrese MF, Bullock AN, Crews CM
Nat Rev Drug Discov. 2019-10-30 . .doi: 10.1038/s41573-019-0047-y
PMID: 31666732Arrowsmith CH, Schapira M
Nat. Struct. Mol. Biol.. 2019-10-5 . 26(10):863-869 .doi: 10.1038/s41594-019-0290-2
PMID: 31582844Schapira M, Harding RJ
F1000Res. 2019-8-27 . 8:87 .doi: 10.12688/f1000research.17710.1
PMID: 31448096Taylor AP, Szewczyk MM, Kennedy S, Trush VV, Wu H, Zeng H, Dong A, de Freitas RF, Tatlock JH, Kumpf RA, Wythes M, Casimiro-Garcia A, Denny RA, Parikh MD, Li F, Barsyte-Lovejoy D, Schapira M, Vedadi M, Brown P, Arrowsmith CH, Owen DR
J. Med. Chem.. 2019-8-15 . .doi: 10.1021/acs.jmedchem.9b00112
PMID: 31415173Mader P, Mendoza-Sanchez R, Iqbal A, Dong A, Dobrovetsky E, Corless VB, Liew SK, Houliston SR, De Freitas RF, Smil D, Sena CCD, Kennedy S, Diaz DB, Wu H, Dombrovski L, Allali-Hassani A, Min J, Schapira M, Vedadi M, Brown PJ, Santhakumar V, Yudin AK, Arrowsmith CH
Bioorg. Med. Chem.. 2019-7-12 . .doi: 10.1016/j.bmc.2019.07.020
PMID: 31327677