The Schapira lab uses computational approaches to analyze the structural chemistry of understudied target classes, to uncover novel opportunities in proximity-induced pharmacology, to explore the chemical space beyond commercial catalogs, and to accelerate hit discovery and hit optimization. The Schapira group also develops databases and user interfaces to navigate data generated at the SGC Toronto and to interface it with open science repositories.
Angela has an Honours BSc degree from the University of Toronto, specializing in Pharmacology and Biomedical Toxicology. As an MSc student, her projects focus on mapping chemical probes on signaling pathways and investigating the ligandability of WDR proteins in silico.
Lihua received her Master's degree in computer science from State University of New York at Stony Brook in 2003. She then worked for SUNY at Stony Brook and Cold Spring Harbor Laboratory as application developer. Lihua joined SGC in 2007 as Informatics Programmer.
Evianne graduated with distinction from Amsterdam University College, earning a B.Sc. in Liberal Arts and Sciences. She is working on the Ligandable Human Genome bioinformatics project. Outside the lab, she plays for UofT's Varsity Women's Field Hockey team and is involved with the PGSA student association.
Lakshi graduated from McMaster University with an Honours B.Sc. in Biomedical Discovery and Commercialization. As an M.Sc. student, she focuses on the classification and structural chemistry of helicases, a disease-associated protein family with few known ligands. Outside the lab, she enjoys hiking with her dog and playing beach volleyball.
Conrad has an M.Sc. from the University of Buea and a Ph.D. in pharmaceutical and medicinal chemistry at Halle University. He uses homology modeling, docking, molecular dynamics, and binding free energy calculations for chemical probe discovery, expanding the Pan-Canadian Chemical Library.