Václav Němec studied Chemistry (BSc.) and later on also Organic Chemistry (MSc. and PhD.) at Masaryk University in Brno, Czech Republic. During his studies in Brno he was involved in several med-chem and chemical biology projects focusing for instance on development of novel kinase inhibitors (CLKs, CK1, ALKs) or inhibitors of Hedgehog signaling. He has spent 7 months in Manchester (UK) on a research stay in laboratories of Prof. David Procter, where he was working on the synthesis of natural product Phaeocaulising based on SmI2 mediated radical cascade reaction. Owing to Jean Marie Lehn scholarship, he spent also one month at EICB Bordeaux (France) in the research group of Prof. Frédéric Friscourt, where he was working on a chemo-enzymatic synthesis of poly-LacNAc chains for binding and study of lectins. In September 2020 he has joined the SGC node at Goethe University in Frankfurt where he is working on development of novel PROTACs and establishment of chemogenomic library.
Eur J Med Chem. 2021 215:113299. doi: 10.1016/j.ejmech.2021.113299
Angew. Chem. Int. Ed. Engl.. 2018 . doi: 10.1002/anie.201810312
Chem Soc Rev. 25.08.2022 . doi: 10.1039/d2cs00478j
Eur J Med Chem. 18.02.2021 215:113299. doi: 10.1016/j.ejmech.2021.113299
Angew. Chem. Int. Ed. Engl.. 20.12.2018 . doi: 10.1002/anie.201810312