Václav Němec

Principal Investigator

Frankfurt

Václav Němec studied Chemistry (BSc.) and later on also Organic Chemistry (MSc. and PhD.) at Masaryk University in Brno, Czech Republic. During his studies in Brno he was involved in several med-chem and chemical biology projects focusing for instance on development of novel kinase inhibitors (CLKs, CK1, ALKs) or inhibitors of Hedgehog signaling. He has spent 7 months in Manchester (UK) on a research stay in laboratories of Prof. David Procter, where he was working on the synthesis of natural product Phaeocaulising based on SmI2 mediated radical cascade reaction. Owing to Jean Marie Lehn scholarship, he spent also one month at EICB Bordeaux (France) in the research group of Prof. Frédéric Friscourt, where he was working on a chemo-enzymatic synthesis of poly-LacNAc chains for binding and study of lectins. In September 2020 he has joined the SGC node at Goethe University in Frankfurt where he is working on development of novel PROTACs and establishment of chemogenomic library.

Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Němec V, Maier L, Berger BT, Chaikuad A, Drápela S, Souček K, Knapp S, Paruch K
Eur J Med Chem. 2021 215:113299. doi: 10.1016/j.ejmech.2021.113299
PMID: 33636538

Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schroeder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, Paruch K
Angew. Chem. Int. Ed. Engl.. 2018 . doi: 10.1002/anie.201810312
PMID: 30569600

2021

Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core.
Němec V, Maier L, Berger BT, Chaikuad A, Drápela S, Souček K, Knapp S, Paruch K
Eur J Med Chem. 18.2.2021 215:113299. doi: 10.1016/j.ejmech.2021.113299
PMID: 33636538

2018

Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schroeder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, Paruch K
Angew. Chem. Int. Ed. Engl.. 20.12.2018 . doi: 10.1002/anie.201810312
PMID: 30569600

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