The Structural Genomics Consortium at the Karolinska Institutet (SGC Karolinska) is interested in studying inflammation and autoimmune diseases based on inflammatory processes, including inflammatory bowel diseases, neuroinflammation and liver fibrosis.
More specifically the research team focuses on three scientific areas:
- Development of cell-based assays on patient-derived cells,
- Generation of recombinant antibodies to selected targets from the SGC network, and
- Validation of chemogenomic tool compounds for selected target families and proteins.
The SGC Karolinska laboratory, under the direction of Prof. Michael Sundström, is housed within the Department of Medicine, Solna at Karolinska Institutet (KI), and is located at the Center for Molecular Medicine.
This SGC research site has a large collaborative network at Karolinska Institutet and affiliated universities. The efforts in chemogenomics take place at the Department of Oncology and Pathology in labs located at the Science for Life Laboratory. The collaborative postdoc network supports postdoctoral fellows in the research groups of Maja Jagodic (Dept. Clinical Neuroscience, KI), Volker Lauschke and Gunnar Schulte (Dept. Physiology and Pharmacology, KI), Pekka Katajisto (Dept. Cell and Molecular Biology, KI), Eduardo Villablanca (Dept. Medicine, KI), David Gloriam (University of Copenhagen) and Rob Leurs & Barbara Zarzycka (Free University Amsterdam). The SGC Karolinska laboratory has research efforts in biotechnology, protein production, phage display, cell culture, patient-derived cell-based assays and screening, as well as chemogenomics and cheminformatics in collaboration with Evert Homan (Dept. Oncology and Pathology, KI).
