The SGC Karolinska lab focuses on three scientific areas i)cell-based assays on patient-derived cells ii) generating recombinant antibodies to selected targets from the SGC network and iii) validation of chemogenomic tool compounds for selected target families and proteins. We have a particular interest in studying inflammation and autoimmune disease based on inflammatory processes including inflammatory bowel diseases, neuroinflammation and liver fibrosis.
The SGC Karolinska laboratory, under the direction of Prof. Michael Sundström, is housed within the Department of Medicine, Solna at Karolinska Institutet (KI), and located at the Centre for Molecular Medicine. We currently have a large collaborative network at Karolinska Institutet and collaborating universities. Our efforts in chemogenomics takes place at the Department of Oncology and Pathology in labs located at Science for Life Laboratory. Our collaborative postdoc network supports postdoctoral fellows in the research groups of Maja Jagodic (Dept. Clinical Neuroscience, KI), Volker Lauschke and Gunnar Schulte (Dept. Physiology and Pharmacology, KI), Pekka Katajisto (Dept. Cell and Molecular Biology, KI), Eduardo Villablanca (Dept. Medicine, KI), David Gloriam (University of Copenhagen) and Rob Leurs & Barbara Zarzycka (Free University Amsterdam).
The SGC Karolinska laboratory has research efforts in biotechnology, protein production, phage display, cell culture, patient-derived cell-based assays and screening, as well as chemogenomics and cheminformatics in collaboration with Evert Homan (Dept. Oncology and Pathology, KI). The SGC encourages collaborations with laboratories across the globe, focused on proteins of medical relevance and their modulators of functions, such as small molecule inhibitors and antibodies.