Jim Kiefer is a structural biologist who has worked in structure-based drug design for more than 20 years, studying protein-ligand complexes, catalytic and inhibitory mechanisms, and target recognition by immune proteins. His primary interests involve pathways triggering cancer and inflammation. He has determined more than 1,000 structures and has worked on a variety of projects. At Genentech, he manages the NMR, crystallography, and CryoEM groups and is actively involved in portfolio strategy. He has led or participated in the steering committees of the SGC, Vernalis, X-CHEM, and Constellation. He is also very active in Genentech mentoring and diversity programs.