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Research Assistant Professor (UNC) - Principal Investigator (SGC)
Alison Axtman is a synthetic medicinal chemist with more than 10 years of research experience working at the interface of chemical and biology. Alison earned her PhD in Medicinal Chemistry at the University of Kansas, and carried out her post-doctoral training in the Department of Chemistry at Stanford University. Alison’s research has focused on the synthesis of small molecules that selectively modulate proteins implicated in disease-propagating pathways. As a member of the GSK Chemical Biology department, she led a program to understand the molecular basis of immune modulation by a class of natural products and developed analogs with improved drug properties. Alison is currently a Research Assistant Professor in the Chemical Biology and Medicinal Chemistry Department in the UNC Eshelman School of Pharmacy. At the SGC-UNC, she leads the design of novel chemical probes for understudied protein kinases that will be openly shared with collaborators to facilitate target discovery in human disease-relevant assays. When she’s not in the lab, Alison can be most often found at the gym preparing for the next CrossFit or GRID competition with her teammates.
2014
Chem. Front. . 2014 1166-1171. doi:
PMID:25632347
2012
Cell Cycle. 2012 3649-55. doi:
PMID:22935698
2011
BMC Cancer . 2011 11:468.. doi:10.1186/1471-2407-11-468
PMID:22039910
Cancer Lett. 2011 158-67. doi:10.1016/j.canlet.2011.07.031
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Med. Chem.. 2011 3839-3853. doi:10.1021/jm200148p
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Med. Chem. Lett. . 2011 684-92. doi:10.1016/j.bmc.2010.10.029
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2010
Cell. 2010 333-43. doi:10.1016/j.molcel.2010.01.005
PMID:20159553
Prostate. 2010 27-36. doi:10.1002/pros.21035
PMID:19739131
2009
Mol Pharmacol.. 2009 1314-22. doi:10.1124/mol.109.058545
PMID:19741006
2023
Alzheimers Dement (N Y). 22.05.2023 9(2):e12394. doi: 10.1002/trc2.12394
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Front Cell Neurosci. 01.05.2023 17:1196543. doi: 10.3389/fncel.2023.1196543
PMID: 37124399
ACS Chem Neurosci. 21.04.2023 . doi: 10.1021/acschemneuro.3c00135
PMID: 37084253
ACS Med Chem Lett. 13.04.2023 14(4):432-441. doi: 10.1021/acsmedchemlett.2c00530
PMID: 37077385
Sci Rep. 14.04.2023 13(1):6118. doi: 10.1038/s41598-023-32854-4
PMID: 37059819
2022
J Med Chem. 16.09.2022 . doi: 10.1021/acs.jmedchem.2c00697
PMID: 36111834
ACS Chem Biol. 19.06.2022 . doi: 10.1021/acschembio.2c00378
PMID: 35723434
J Biol Chem. 26.04.2022 101986. doi: 10.1016/j.jbc.2022.101986
PMID: 35487243
Alzheimers Dement (N Y). 28.04.2022 8(1):e12246. doi: 10.1002/trc2.12246
PMID: 35475262
Alzheimers Dement (N Y). 19.04.2022 8(1):e12253. doi: 10.1002/trc2.12253
PMID: 35434254
2021
Front Cell Neurosci. 07.12.2021 15:768655. doi: 10.3389/fncel.2021.768655
PMID: 34867205
Biochim Biophys Acta Gen Subj. 18.09.2021 130014. doi: 10.1016/j.bbagen.2021.130014
PMID: 34547390
J Med Chem. 01.08.2021 . doi: 10.1021/acs.jmedchem.1c00440
PMID: 34333981
RSC Med Chem. 01.01.2021 12(1):129-136. doi: 10.1039/d0md00292e
PMID: 34046605
Cell Chem Biol. 11.01.2021 . doi: 10.1016/j.chembiol.2020.12.013
PMID: 33484635
Int J Mol Sci. 08.01.2021 22(2):. doi: 10.3390/ijms22020566
PMID: 33429995
2020
Sci Rep. 28.09.2020 10(1):15826. doi: 10.1038/s41598-020-72869-9
PMID: 32985588
ACS Chem Neurosci. 16.09.2020 11(18):2783-2785. doi: 10.1021/acschemneuro.0c00548
PMID: 32933260
ACS Chem Neurosci. 28.05.2020 . doi: 10.1021/acschemneuro.0c00176
PMID: 32464049
ACS Med Chem Lett. 12.03.2020 11(3):340-345. doi: 10.1021/acsmedchemlett.9b00399
PMID: 32184967
2019
Nat Rev Drug Discov. 04.07.2019 18(7):489. doi: 10.1038/d41573-019-00076-x
PMID: 31267068
Cell Rep. 02.01.2019 26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023
PMID: 30605688
. 03.09.2019 . doi: 10.26434/chemrxiv.9756785.v1
PMID:
ACS Medicinal Chemistry Letters. 29.10.2019 . doi: 10.1021/acsmedchemlett.9b00399
PMID:
2018
Sci Signal. 25.09.2018 11(549):. doi: 10.1126/scisignal.aau0597
PMID: 30254053
SLAS Discov. 01.05.2018 2472555218773045. doi: 10.1177/2472555218773045
PMID: 29742358
2017
PLoS ONE. 03.08.2017 12(8):e0181585. doi: 10.1371/journal.pone.0181585
PMID: 28767711