Publications

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2026

"EXPERT" A Practical and Forward-Looking Guide to Capturing Protein Expression and Purification Metadata to develop Machine Learning Models.

Cooper CDO, Tankhilevich E, Remans K, El Marjou A, Edwards AM, Leach A, Quigley A, Schutz A, Zemella A, de Marco A, Sivertsson Å, Borgonovo B, Kemp B, Voldborg B, Carolis C, Mitchell C, Wickstrand C, Owen DR, Drechsel D, Jones D, Oyarzún DA, Esposito D, Geertsma E, Krupinska E, Bernhard F, Ferreira-da-Silva F, Tegel H, Hunt I, Berger I, Love J, Dohnalek J, Thies J, Basquin J, Coker J, Buyel J, van den Heuvel J, Haustraete J, Dürr KL, Lau K, Hedfalk K, Bozovicar K, Liu L, Bamber L, Scietti LA, Bäckström M, Schubert M, Elvin M, Pelosse M, Todd M, Schapira M, Alblova M, Berrow NS, Marinchev Dobrev N, Brodsky O, Vaněk O, Gileadi O, Dossang P, Storici P, Celie P, Wan P, Loppnau PA, Harding R, Owens R, Vincentelli R, Altman R, Davies R, Meijers R, Kim R, Saxl R, Suppmann S, Velankar S, Pasqualato S, Cuesta SM, Petres S, Harborne S, Witt S, Kjaer S, Unger T, Craig T, Danieli T, Sarkans U, Knecht W, Kuttenlochner W, Peleg Y, Schiavone LH, Burgess-Brown NA

J Biol Chem. 113610. doi: 10.1016/j.jbc.2026.113610

Publication date: September 29, 2026

PMID: 42810683

A guide to selecting high-performing antibodies for ARID1B (UniProt ID: Q8NFD5) for use in western blot and immunoprecipitation.

Moleón VR, Bolívar SG, Ayoubi R, Francis V, McPherson PS, Laflamme C

F1000Res. 15:631. doi: 10.12688/f1000research.179398.1

Publication date: September 29, 2026

PMID: 42806975

A guide to selecting high-performing antibodies for Prosaposin (UniProt ID: P07602) for use in western blot and immunoprecipitation.

Moleón VR, Bolívar SGB, Ayoubi R, Francis V, McPherson PS, Laflamme C

F1000Res. 15:1065. doi: 10.12688/f1000research.177779.1

Publication date: September 28, 2026

PMID: 42802730

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen.

Zhao Z, Upadhyay R, Eddershaw A, Wang C, Zhao Y, Wallner O, Ryu J, Taebnia N, Gildie H, Scaletti-Hutchinson E, Davies JR, Ziegler N, Krämer A, Robinson SC, Varga M, Singerova K, Szaruga Z, Wiita E, Güneş İ, David SS, Knapp S, Kannt A, de Vega M, Stenmark P, Lauschke VM, Michel M

Adv Sci (Weinh). e77956. doi: 10.1002/advs.77956

Publication date: September 27, 2026

PMID: 42801551

A guide to selecting high-performing antibodies for Netrin-1 (UniProt ID: O95631) for use in western blot and immunoprecipitation.

Ayoubi R, Bolívar SG, Kahn RA, Francis V, McPherson PS, Laflamme C

F1000Res. 15:1129. doi: 10.12688/f1000research.184099.1

Publication date: September 19, 2026

PMID: 42760910

Cell type-selective targeting by heterobifunctional protein binders via in-cell enrichment.

Bulldan A, Zheng M, Meyners C, Purder PL, Krieger J, Dreizler JK, Geiger TM, Repity ML, Lein MH, Quist-Løkken I, Tewes N, Smith ER, Schwab K, Fischer M, Schwalm MP, Dey R, Aswathaman Sivashanmugam S, Schlesiger S, Moniot S, Knapp S, Hartung IV, Holien T, Loewer A, Hausch F

Nat Commun. 17(1):. doi: 10.1038/s41467-026-77460-w

Publication date: September 18, 2026

PMID: 42754590

Modulating pseudokinase conformation from the ATP-binding site.

Sheetz JB, Tsutsui Y, Ashtekar KD, Mathea S, Knapp S, Lemmon MA

Structure. doi: 10.1016/j.str.2026.08.013

Publication date: September 18, 2026

PMID: 42759518

A chromatin-informed transcriptional regulatory framework to stratify patients and guide therapy selection in triple-negative breast cancer.

Bahl S, Dogan-Artun N, Nguyen J, Mahmoud H, Ba-Alawi W, Madani Tonekaboni SA, Kang KK, McGuire M, Tobin C, Silvester J, Savage P, Cressot L, Nand A, Feng G, Guilhamon P, Mer AS, Arlidge C, Elliott MJ, Park M, Cescon DW, Haibe-Kains B, Lupien M

Nat Commun. 17(1):. doi: 10.1038/s41467-026-76385-8

Publication date: September 17, 2026

PMID: 42749733

A guide to selecting high-performing antibodies for DJ-1 ( PARK7) (Q99497) for use in western blot, immunoprecipitation, and immunofluorescence.

Zha C, Alende C, Fotouhi M, Bolívar SG, Ayoubi R, Francis V, McPherson PS, Laflamme C

F1000Res. 15:989. doi: 10.12688/f1000research.182633.1

Publication date: September 13, 2026

PMID: 42728985

A guide to selecting high-performing antibodies for Syntenin-1 (O00560) for use in western blot, immunoprecipitation, and immunofluorescence.

Moleón VR, Alende C, Fothouhi M, Bolívar SG, Ayoubi R, Francis V, McPherson PS, Laflamme C

F1000Res. 15:1021. doi: 10.12688/f1000research.183125.1

Publication date: September 13, 2026

PMID: 42732170

A guide to selecting high-performing antibodies for TMEM175 (UniProt ID: Q9BSA9) for use in western blot, immunoprecipitation, and immunofluorescence.

Moleón VR, Alende C, Fothouhi M, Bolívar SG, Ayoubi R, Francis V, McPherson PS, Laflamme C

F1000Res. 15:942. doi: 10.12688/f1000research.182354.1

Publication date: September 13, 2026

PMID: 42728995

A guide to selecting high-performing renewable antibodies for KIF5A (Q12840) across western blot, immunoprecipitation, and immunofluorescence.

Ayoubi R, Alende C, Fothouhi M, Bolívar SG, Francis V, McPherson PS, Laflamme C

F1000Res. 15:1030. doi: 10.12688/f1000research.184178.1

Publication date: September 13, 2026

PMID: 42732114

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137.

Zerva A, Raig ND, Zhuang Z, Krämer A, Dopfer J, Togashi RK, Schwalm MP, Elson L, Frischkorn JM, Berger BT, Müller S, Chen JK, Knapp S, Hanke T

J Med Chem. 69(17):20616-20638. doi: 10.1021/acs.jmedchem.6c01320

Publication date: September 10, 2026

PMID: 42720483

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer.

Torres-Fernández LA, Boehm V, Kaufmann J, Becker JP, Garcia-Marquez M, de Bruijn B, Rumińska A, Müller C, Bosco G, Alavinejad N, Lovric L, Bihler JI, Schulte H, Davoodi P, Schöllhorn A, Weihrauch KR, Kaiser L, Ibruli O, Liu F, Androulidaki A, Wobst N, Schmiel M, Valiulis J, Maas L, D'Rozario J, Sakthivelu V, Göbel B, Touet M, Brägelmann J, Höpker K, John F, Wolf J, Knapp S, Quaas A, Cartolano M, von Karstedt S, Beleggia F, Rammensee HG, Gouttefangeas C, Schlößer HA, Riemer AB, Reinhardt HC, Gehring NH, Peifer M, Thomas RK, George J

Mol Cancer. 25(1):. doi: 10.1186/s12943-026-02750-2

Publication date: September 9, 2026

PMID: 42711693

Accelerate Your Science: Direct-to-Biology Strategies in Medicinal Chemistry.

Hiesinger K, Knapp S

J Med Chem. 69(16):19560-19592. doi: 10.1021/acs.jmedchem.6c00996

Publication date: September 1, 2026

PMID: 42679148

Targeting the RNA-Binding Site of SARS-CoV-2 NSP13 by FRASE-bot in CACHE Challenge #2.

Wang X, Mettu A, Herasymenko O, Silva M, Houliston S, Chau I, Ghiabi P, Gibson E, Perveen S, Seitova A, Schapira M, Kireev D

J Chem Inf Model. 66(16):10318-10325. doi: 10.1021/acs.jcim.6c00560

Publication date: August 31, 2026

PMID: 42670858

Fragment-Based Discovery of Fenamic Acids as Pan-Species Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.

Zhu WF, Feugray G, Brunst S, Messaoudi H, Yang M, Martinez-Conde N, Krämer A, Weizel L, Ehrler JMH, Kramer JS, Kaiser A, Al-Tarrass M, Pereira T, Valet M, Brunel V, Schubert-Zsilavecz M, Knapp S, Lillich FF, Hernandez-Olmos V, Duflot T, Hiesinger K, Qian H, Proschak A, Bellien J, Proschak E

ACS Chem Biol. 21(8):2053-2067. doi: 10.1021/acschembio.6c00502

Publication date: August 22, 2026

PMID: 42631699

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids.

Syphers JL, Wright JA, Kumar A, To N, Elson L, Krämer A, Müller S, Morasch V, Chang A, Young S, Sloan EK, de Nys R, Silva TN, Vrbanac L, Barratt KR, Leeflang J, Hasan ST, Gable RW, Knapp S, Worthley DL, Mukherjee S, Stockton K, Woods SL, Priebbenow DL, Baell JB

J Med Chem. doi: 10.1021/acs.jmedchem.6c00018

Publication date: August 20, 2026

PMID: 42623604

Selective Brain-Penetrant TTBK1 Inhibitors Modulate TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of TDP-43 Proteinopathy.

Sanchez-Santos C, Jimenez-Amor A, Martinez-Gonzalez L, Nozal V, Martin-Morales R, Aledavood E, Bausela D, Merrigan K, Diaz-Palacios K, Zhubi R, Knapp S, Garcia-Gonzalo FR, Rodriguez-Cueto C, Gil C, de Lago E, Martinez A

J Med Chem. 69(15):19451-19481. doi: 10.1021/acs.jmedchem.6c01882

Publication date: August 13, 2026

PMID: 42593908

Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human Type II Transmembrane Serine Proteases.

Fraser BJ, Wilson RP, Lac J, Ilyassov O, Seitova A, Li Y, Hutchinson A, Li YY, Loppnau P, Kutera M, Morin GB, Benard F, Arrowsmith CH

J Biol Chem. 113440. doi: 10.1016/j.jbc.2026.113440

Publication date: August 12, 2026

PMID: 42586429

The structural basis for LRRK2's activation and autoinhibition.

Villagran Suarez A, Hatch KS, Bodrug T, Gai W, Surridge KJ, Moussikhina E, Nguyen KHV, Sanz-Murillo M, Callahan R, Xiong E, Ramos D, Zhu L, Dederer V, Mathea S, Iwasa J, Knapp S, Shokat KM, Reck-Peterson SL, Leschziner AE

Cell. doi: 10.1016/j.cell.2026.07.027

Publication date: August 11, 2026

PMID: 42575089

Biophysical and Cellular Assays for the Evaluation of Peptidomimetic Inhibitors Based on Degron Sequences.

Lenz C, Saxena K, Knapp S

Methods Mol Biol. 3069:103-124. doi: 10.1007/978-1-0716-5508-5_7

Publication date: August 10, 2026

PMID: 42573692

Utilization of Functional Degradation Pathways for the Characterization of Ubiquitin-Proteasome System Tool Compounds.

Frischkorn JM, Riching K, Knapp S, Schwalm MP

Methods Mol Biol. 3069:33-51. doi: 10.1007/978-1-0716-5508-5_3

Publication date: August 10, 2026

PMID: 42573688

Chemogenomic sets: valuable tools for early-stage drug discovery.

Schoppa MQ, Drewry DH

Essays Biochem. doi: 10.1042/EBC20260007

Publication date: July 30, 2026

PMID: 42529985

The enabling power of chemical probes: examples from the nuclear hormone receptor field.

Willson TM, Merk D

Essays Biochem. doi: 10.1042/EBC20260016

Publication date: July 23, 2026

PMID: 42488934

An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions.

Madhu P, Benz C, Simonetti L, Winters MJ, Subbanna MS, Kliche J, Gomez-Lucas L, Kotb HM, Krystkowiak I, Segal D, Darling WTP, Larsen-Ledet S, Vieler M, Zupancic A, Konstantinou A, Mihalic F, Varga JK, Pagano L, Lüchow S, Kraemer A, Ellingboe L, Görlitz K, Righetto GL, Kossmann C, Xiong R, Schueler-Furman O, Halabelian L, Santhakumar V, Arrowsmith C, Knapp S, Erdelyi M, Stein A, Vincentelli R, Pryciak PM, Davey NE, Ivarsson Y

bioRxiv. doi: 10.64898/2026.07.03.735260

Publication date: July 17, 2026

PMID: 42465437

Quantum Pharmacophore-Based Virtual Screening Enables Prospective Discovery of Chemotype-Diverse Dengue NS5 Inhibitors.

Martinov MN, Van Den Bergh A, Jacoby E, Kirov I, Nashev LG, Herasymenko O, Arrowsmith CH, Slater JW, Grell T, Maksimchuk K, Hack MD, Wu Z, Ohadi D, Borrenberghs D, Van Loock M, Mulakala C, Goethals O

J Chem Inf Model. doi: 10.1021/acs.jcim.6c01051

Publication date: July 16, 2026

PMID: 42462159

Fragility of precision: resistance to mutant p53 reactivation.

Joerger AC, Stiewe T

Signal Transduct Target Ther. 11(1):. doi: 10.1038/s41392-026-02830-1

Publication date: July 13, 2026

PMID: 42437754

Riding toward Selectivity: Optimization of Covalent 7-Azaindole-Based BMX Kinase Inhibitors.

Liang XJ, Albertini C, Kronenberger T, Shevchenko E, Rasch A, Berger BT, Schwalm M, Berger LM, Krämer A, Serafim RAM, Forster M, Chaikuad A, Bolognesi ML, Müller S, Poso A, Laufer S, Knapp S, Gehringer M

J Med Chem. doi: 10.1021/acs.jmedchem.6c01366

Publication date: July 13, 2026

PMID: 42441922

Site-Specific Hydrogen-Deuterium Exchange Mass Spectrometry for Deep Explorations of Dynamic Shifts in Protein-Drug Interactions.

Anacleto J, Wolf E, Ackloo S, Arrowsmith C, LeBlanc Y, Lento C, Wilson DJ

J Am Chem Soc. doi: 10.1021/jacs.6c03259

Publication date: July 9, 2026

PMID: 42420201

AURORA A interacts with DICER and SETD2 to promote S-phase progression.

Müller J, Daunke T, Berner N, Bhandare P, Gebhardt A, Hoffmann L, Diebold M, Vogt M, Hofstetter J, Cruz-Garcia Y, Dudvarski-Stankovic N, Schneider K, Adhikari B, Lamer S, Schlosser A, Büchel G, Sos ML, Küster B, Knapp S, Wilhelm S, Wolf E

EMBO Rep. doi: 10.1038/s44319-026-00850-0

Publication date: July 1, 2026

PMID: 42380670

Auto-segmentation of organs-of-interest clinical acceptability & reproducibility framework in head and neck cancer.

Marsilla J, Welch ML, Siraj J, McElcheran C, Kim JW, Tkachuck D, Kim S, Cho J, Hahn E, Hosni A, Jacinto JC, Kazmierski M, Rey-McIntyre K, Huang SH, Patel T, Tadic T, Bratman S, Hope A, Haibe-Kains B

Phys Imaging Radiat Oncol. 39:101015. doi: 10.1016/j.phro.2026.101015

Publication date: June 30, 2026

PMID: 42376454

Structure-Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile.

Betzholz T, Liu T, Krämer A, Dederer V, Knapp S, Mathea S, Ducho C, Engel M

ChemMedChem. 21(11):e202501007. doi: 10.1002/cmdc.202501007

Publication date: June 18, 2026

PMID: 42313448

On the Scope of DCAF1-Recruiting PROTACs Degrading Protein Kinases.

Weckesser J, Miletić N, Sivashanmugam SA, Ohmayer U, Steger M, Shashikadze B, Gehrtz P, Unzue Lopez A, Wegener A, Dietz TY, Hammann T, Hartung IV, Elson L, Němec V, Schwalm MP, Adhikari B, Wolf E, Krämer A, Müller S, Daub H, Knapp S

J Med Chem. doi: 10.1021/acs.jmedchem.6c00383

Publication date: June 17, 2026

PMID: 42304961

p21-Activated Kinase (PAK) Group I-Targeting Inhibitors Promote the Dimeric Conformation in Live Cells.

Ehret TAL, Berger BT, Raig N, Nowotka F, Manik N, Morasch V, Krämer A, Elson L, Matos TL, Müller S, Knapp S, Schwalm MP

ACS Chem Biol. doi: 10.1021/acschembio.6c00410

Publication date: June 15, 2026

PMID: 42287201

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

Yang D, Wang X, Liu J, Gong Y, Nair P, Sun J, Qian X, Cui J, Zeng H, Dong A, Harding RJ, Burgess-Brown N, Beyett TS, Song D, Krause HM, Diamond ML, Bolhuis DL, Brown NG, Arrowsmith CH, Edwards AM, Halabelian L, Peng H

Proc Natl Acad Sci U S A. 123(25):e2515940123. doi: 10.1073/pnas.2515940123

Publication date: June 5, 2026

PMID: 42247526

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States.

Corrionero A, Prendiville N, Cazorla T, Baena-Nuevo M, Sandra R, Camafeita E, Knapp S, Alfonso P

ChemMedChem. 21(11):e70331. doi: 10.1002/cmdc.70331

Publication date: June 4, 2026

PMID: 42236317

A guide to selecting high-performing antibodies for ARID2 (UniProt ID: Q68CP9) for use in western blot, immunoprecipitation, and immunofluorescence.

Moleón VR, Alende C, Fothouhi M, Bolívar SG, Ayoubi R, Francis V, McPherson PS, Laflamme C

F1000Res. 15:614. doi: 10.12688/f1000research.179367.1

Publication date: June 3, 2026

PMID: 42232299

ABHD2 activity is not required for the non-genomic action of progesterone on human sperm.

Edwards M, Amaral A, Carter EM, Arnolds O, Vester K, Thrun A, Wigren E, Homan E, Ribera P, Bentley K, Haraldsson M, Theo-Emegano N, Loppnau P, Szewczyk MM, Cao MA, Barsyte-Lovejoy D, Dittmar N, Hans A, Weber M, Münchow J, Zhu WF, Temme L, Brenker C, Strünker T, Sundström M, Todd MH, Edwards AM, Lesche R, Gileadi O, Tredup C

Hum Reprod. doi: 10.1093/humrep/deag085

Publication date: May 29, 2026

PMID: 42212558

Design and Synthesis of Pyrimidino[4,5-d]Pyrimidine-Based Compounds as Potent B-RAF V600E Inhibitors.

Georgiou EA, Christopoulou K, Kalampaliki AD, Giannopoulou AF, Chatziorfanou E, Bafiti V, Krämer A, Papakyriakou A, Stravopodis DJ, Knapp S, Kostakis IK

ChemMedChem. 21(11):e70324. doi: 10.1002/cmdc.70324

Publication date: May 29, 2026

PMID: 42208521

Identification and Validation of 3-Cyano-Quinoline Ligands Targeting Integrin-Linked Kinase (ILK).

Greco FA, Abdul Azeez KR, Mitrović M, Sivashanmugam SA, Schwalm MP, Preuss F, Chatterjee D, Morasch V, Mathea S, Hanke T, Müller S, Knapp S

J Med Chem. doi: 10.1021/acs.jmedchem.5c03773

Publication date: May 26, 2026

PMID: 42185966

Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.

Bourg S, Place M, Copin C, Chaikuad A, Robert T, Holzmann H, Müller S, Bach S, Ruchaud S, Knapp S, Buron F, Routier S, Bonnet P

Eur J Med Chem. 315:118977. doi: 10.1016/j.ejmech.2026.118977

Publication date: May 24, 2026

PMID: 42176653

In vitro screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives CDKN1 and BBC3 expression to restore a p53-dependent cytotoxicity.

Nannini S, Sieffert C, McGown A, Gao XY, Jarvis A, Kostakis GE, Galvacsi A, Kallay C, Moraru R, Baud MG, Mandel S, Balourdas DI, Joerger AC, Orvain C, Peschard S, Nion A, Mellitzer G, Lottiaux S, Spencer J, Gross I, Gaiddon C

J Enzyme Inhib Med Chem. 41(1):2638836. doi: 10.1080/14756366.2026.2638836

Publication date: May 21, 2026

PMID: 42163716

Large-scale discovery, analysis and design of protein energy landscapes.

Ferrari ÁJR, Dixit SM, Thibeault J, Garcia M, Houliston S, Ludwig RW, Notin P, Phoumyvong CM, Martell CM, Jung MD, Tsuboyama K, Carter L, Arrowsmith CH, Guttman M, Rocklin GJ

Nature. doi: 10.1038/s41586-026-10465-z

Publication date: May 14, 2026

PMID: 42129553

Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors.

Klink N, Urban S, Seier JA, Adhikari B, Schwalm MP, Müller J, Dorsch M, Steinbach P, Jung J, Vogt M, Kaschani F, Koch J, Führer S, Kaiser M, Schulze N, Knapp S, Wolf E, Paschen A, Grüner BM, Gersch M

Nat Commun. 17(1):. doi: 10.1038/s41467-026-72295-x

Publication date: May 14, 2026

PMID: 42129197

Comprehensive kinase inhibitor screening reveals potential therapeutic targets in canine melanoma: A Comparative Precision Oncology study.

Andriotti LA, Xavier PLP, Rochetti AL, Qazi TJ, Ferrero AT, de Francisco Strefezzi R, Gomes COMS, Dagli MLZ, Leitão A, Da Silva ER, Muller S, Fukumasu H

Res Vet Sci. 208:106246. doi: 10.1016/j.rvsc.2026.106246

Publication date: May 12, 2026

PMID: 42114276

Drugs that act on both G protein-coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy.

Ljunggren H, Sokolov A, Ballante F, Fredriksson R, Lagunas-Rangel F, Hauser AS, Knapp S, Jonsson J, Schiöth HB

Br J Pharmacol. doi: 10.1111/bph.70481

Publication date: May 11, 2026

PMID: 42108658

Targeting Activin Receptor-like Kinase 2 Using Heterobifunctional Protein Degraders.

Webb DT, Jones KL, Macabuag N, Bago R, Betts J, Bhattacharyya S, Clifton S, Tinson RAJ, Achara C, Gilbert S, Howell S, Drewry DH, Rogers R, Jones C, Ferguson KR, Bullock AN, Lindsay DM, Kerr WJ, Esmieu W

J Med Chem. doi: 10.1021/acs.jmedchem.6c00714

Publication date: May 4, 2026

PMID: 42076879

Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader.

Azeez KRA, Saraswati H, Mosler T, Hanke T, Ho-Xuan H, Neder N, Sivashanmugam SA, Heinz M, Schwalm MP, Giuliani G, Rathore R, Kazi R, Kumar R, Mitrovic M, Prieto-Garcia C, Bailey HJ, Mathea S, Hummer G, Đikić I, Müller S, Stolz A, Krause DS, Knapp S

ACS Chem Biol. doi: 10.1021/acschembio.6c00137

Publication date: May 1, 2026

PMID: 42066056

DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants.

Münick P, Balourdas DI, Funk JS, Yüksel B, Mavridi D, Heftel J, Dreier B, Schaefer JV, Schäfer B, Knapp S, Telatar T, Akgül B, Plückthun A, Stiewe T, Joerger AC, Dötsch V

Proc Natl Acad Sci U S A. 123(18):e2531747123. doi: 10.1073/pnas.2531747123

Publication date: April 28, 2026

PMID: 42048463

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