The SGC operates from six academic institutions - the University of Toronto, University of North Carolina and Chapel Hill, Karolinska Institute, Goethe University Frankfurt, McGill University and University College London. In these six SGC labs, there is a remarkable level of engagement and exchange with their respective local academic communities, with an excess of 200 scientists, visitors, collaborators and support personnel at any time working on several research areas.
The labs employ, develop and exchange high-throughput structural biology, medicinal chemistry and assay development expertise and protocols and are unified through a common informatics platform, ensuring seamless flow of information and integration. In parallel, built within this integrated platform, SGC sites conduct several, non-overlapping scientific programmes aimed at exploring pioneer targets and biology.
The SGC-Toronto laboratory, under the direction of Professor Cheryl Arrowsmith, operates within the Temerty Faculty of Medicine at the University of Toronto and is located in the MaRS Discovery District, at the heart of cosmopolitan Toronto.
The SGC Karolinska under the direction of Prof. Michael Sundström, is housed within the Department of Medicine, Solna at Karolinska Institutet (KI), and located at the Centre for Molecular Medicine.
The SGC Frankfurt laboratory is housed within the Faculty of Biochemistry, Chemistry and Pharmacy at the Goethe University Frankfurt. The Frankfurt site was established in 2017 with Prof. Stefan Knapp as Chief Scientist.
The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC-UNC) is a team of scientists dedicated to discovering and sharing selective, small molecule chemical probes of the dark proteome. Their work aims to facilitate the discovery of new molecular targets for drug discovery and help speed the creation of new medicines for patients.
SGC UCL is an initiative led by Dr. Matthew Todd from his laboratory at University College London. The aim of the Open Chemistry Networks (OCN) initiative is to bring together synthetic chemists and SGC biochemistry and biology to synthesize and characterize new bioactive small molecules (chemical probes) and use them to accelerate the search for new medicines.
The SGC Neuro laboratories, under the direction of Dr. Edward Fon, are housed at the Montreal Neurological Institute and the McIntyre Medical Sciences Building, and affiliated with McGill University’s departments of Neurology and Neurosurgery, Pharmacology and Therapeutics and Human Genetics.