SGC Chemical Probes

The table below contains the entire collection of probes from SGC’s chemical probes program. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers. 

To acquire a sample, follow the links on the webpage of your desired chemical probe.

Brochure_Chemical Probes (May 2024)

Probe Name Protein Family Target protein Control name Probe structure Cellular usage
TP-061 Helicases Brr2 TP-061N Yes
Bromosporine (BSP) Bromodomains pan-Bromodomain Yes
UNC1215 Methyl Lysine Binder L3MBTL3 UNC1079 Yes
SGC0946 Methyltransferase DOT1L SGC0649 Yes
UNC0642 Methyltransferase EHMT2/G9a, EHMT1/GLP Yes
GSK343 Methyltransferase EZH2 Yes
GSK-J1 Lysine Demethylase KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B GSK-J2 (GSK-J5) Yes
IOX2 2OG PHD2 Yes
IOX1 2OG Pan-KDM Yes
PFI-1 Bromodomains BRD2, BRD3, BRD4, BRDT Yes
UNC0638 Methyltransferase EHMT2/G9a, EHMT1/GLP UNC0737 Yes
(+)-JQ1 Bromodomains BRD2, BRD3, BRD4, BRDT (-)-JQ1 Yes
MS023 Methyltransferase PRMT1, PRMT3, CARM1, PRMT6, PRMT8 MS094 Yes
MS049 Methyltransferase CARM1, PRMT6 MS049N Yes
NVS-CECR2-1 Bromodomains CECR2 NVS-CECR2-C Yes
I-BRD9 Bromodomains BRD9 Yes
BI-9564 Bromodomains BRD9, BRD7 Yes
BAY-598 Methyltransferase SMYD2 BAY-369 Yes
GSK484 Arginine deiminases PAD4 GSK106 Yes
GSK2801 Bromodomains BAZ2A, BAZ2B GSK8573 Yes
LP99 Bromodomains BRD9, BRD7 2S,3R-enantiomer Yes
NI-57 Bromodomains BRPF1, BRD1, BRPF3 Yes
PFI-4 Bromodomains BRPF1 Yes
OF-1 Bromodomains BRPF1, BRD1, BRPF3 Yes
SGC707 Methyltransferase PRMT3 XY1 Yes
BAZ2-ICR Bromodomains BAZ2A, BAZ2B Yes
OICR-9429 WD40 repeat WDR5 OICR-0547 Yes
GSK-LSD1 Lysine Demethylase KDM1A/LSD1 Yes
LLY-507 (multiple off-targets) Methyltransferase SMYD2 SGC705 Yes
PFI-3 Bromodomains SMARCA2, PBRM1, SMARCA4 PFI-3oMet Yes
A-366 Methyltransferase EHMT1/GLP, EHMT2/G9a Yes
UNC1999 Methyltransferase EZH2 UNC2400 Yes
(R)-PFI-2 Methyltransferase SETD7 (S)-PFI-2 Yes
SGC-CBP30 Bromodomains CREBBP, EP300 BDOIA513 Yes
I-CBP112 Bromodomains CREBBP, EP300 Yes
SGC3027 Methyltransferase PRMT7 SGC3027N No
SGC-GAK-1 Kinase GAK SGC-GAK-1N No
SGC-AAK1-1 Kinase AAK1, BMP2K, BIKE SGC-AAK1-1N No
BI01383298 Solute carriers SLC13A5 BI01372674 No
L-Moses Bromodomains KAT2A, KAT2B D-Moses Yes
TH-257 Kinase LIMK1, LIMK2 TH-263 No
SKI-73 Methyltransferase CARM1 SKI-73N No
PFI-5 Methyltransferase SMYD2 PFI-5N No
BAY-6035 Methyltransferase SMYD3 BAY-444 No
GSK4027 Bromodomains KAT2A, KAT2B GSK4028 No
FM-381 Kinase JAK3 FM-479 No
BAY-850 Bromodomains ATAD2 BAY-460 No
GSK8814 Bromodomains ATAD2, ATAD2B GSK8815 No
GSK6853 Bromodomains BRPF1 GSK9311 Yes
LLY-283 Methyltransferase PRMT5 LLY-284 No
A-395 WD40 repeat EED A-395N No
TP-472 Bromodomains BRD9, BRD7 TP-472N Yes
TP-064 Methyltransferase CARM1 TP-064N No
BAY-299 Bromodomains TAF1, BRD1 BAY-364 Yes
NVS-PAK1-1 Kinase PAK1 NVS-PAK1-C Yes
GSK864 Dehydrogenase IDH1 GSK990 Yes
A-196 Methyltransferase SUV420H1, SUV420H2 A-197, SGC2043 Yes
GSK591 Methyltransferase PRMT5 SGC2096 Yes
MU1700 Kinase ALK1, ALK2 MU1700NC Yes
M4K2234 Kinase ALK1, ALK2 M4K2234NC Yes
SGC-UBD253 UBD (ubiquitin binding domain) HDAC6 SGC-UBD253N Yes
CK156 Kinase STK17A, DRAK1 CKJB71 Yes
PFI-7 E3 ligase GID4 PFI-7N Yes
MRIA9 Kinase SIK1, SIK2, SIK3 MR7 Yes
Homer WD40 repeat WDR5 nc_WDR5 and nc_VHL Yes
SGC-SMARCA-BRDVIII Bromodomains PB1(5), SMARCA2/4 SGC-BRDVIII-NC No
NR162 Kinase CASK NR187 Yes
PFI-6 YEATS MLLT1, MLLT3 PFI-6N Yes
SGC-CK2-1 Kinase CSNK2A1, CSNK2A2 SGC-CK2-1N Yes
NVS-MLLT-1 YEATS MLLT1, MLLT3 NVS-iMLLT-C Yes
SGC-STK17B-1 Kinase STK17B, DRAK2 SGC-STK17B-1N No
SGC-CLK-1 Kinase CLK1, CLK2, CLK4 SGC-CLK-1N Yes
SGC-CAMKK2-1 Kinase CAMKK1, CAMKK2 SGC-CAMKK2-1N Yes
SGC6870 Methyltransferase PRMT6 SGC6870N No
UNC6934 Methyl Lysine Binder NSD2-PWWP1 UNC7145 No
MU1210 Kinase CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 MU140 Yes
NVS-BPTF-1 Bromodomains BPTF NVS-BPTF-C Yes
VinSpinIn Spindlin domains Spin1 VinSpinIC No
TP-238 Bromodomains CECR2, BPTF TP-422 No
DDR-TRK-1 Kinase DDR, TRK DDR-TRK-1N Yes
BI-9321 Methyl Lysine Binder NSD3 BI-9466 No
MRK-740 Methyltransferase PRDM9 MRK-740-NC No
SGC-UBD1031 UBD (ubiquitin binding domain) SGC-UBD1031N Yes
UNC8732 Methyl Lysine Binder NSD2 UNC8884 Yes
OICR11029 Transcription factor BCL6 OICR11600 Yes
PFI-8 YEATS YEATS PFI-8N Yes
JA310 Kinase MST3, MST4 JA262 No
SGC-GSK3-1 Kinase GSK3 SGC-CDKL5/GSK3-1N Yes
SGC-CDKL5_GSK3 Kinase CDKL5, GSK3 SGC-CDKL5/GSK3-1N Yes
SGC-CAF382-1 Kinase CDKL5 SGC-CAF268-1N No
TH-257 Kinase LIMK1, LIMK2 TH-263 No
JA397 Kinase CDK14-18 JA314 No
SGC-PI5P4Kγ/MYLK4-1 Kinase PI5P4K gamma, MYLK4 SGC-PI5P4Kγ/MYLK4-1N Yes
SGC-CK2-2 Kinase CK2/CSNK2 SGK-CK2-2N No
MSC1186 Kinase SRPK MSC5360 No
CS640 Kinase CAMK1 CS640s Yes
MU1742 Kinase CK1δ, CK1ε MU2027 Yes
BAY-805 USP (ubiquitin specific protease) USP21 BAY-728 Yes
MRK-952 Hydrolase NUDT5 MRK-952-NC Yes
MRK-990 Methyltransferase PRMT9, PRMT5 MRK-990-NC Yes
SGC-PIKFYVE-1 Kinase PIKfyve SGC-PIKFYVE-1N Yes