The table below contains the entire collection of probes from SGC’s chemical probes program. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers.
To acquire a sample, follow the links on the webpage of your desired chemical probe.
| Probe Name | Protein Family | Target protein | Control name | Probe structure | Cellular Usage |
|---|---|---|---|---|---|
| OICR-41103 | WD40 repeat | DCAF1 | OICR-41103N |
|
1 µM; not to exceed 5 µM |
| SGC-CDKL2/AAK1/BMP2K-1 | Kinase | CDKL2 | CDKL2/AAK1/BMP2K -1N |
|
≤1 µM |
| TP-061 | Helicases | Brr2 | TP-061N |
|
5 µM |
| Bromosporine (BSP) | Bromodomains | pan-Bromodomain |
|
||
| UNC1215 | Methyl Lysine Binder | L3MBTL3 | UNC1079 |
|
|
| SGC0946 | Methyltransferase | DOT1L | SGC0649 |
|
|
| UNC0642 | Methyltransferase | EHMT2/G9a, EHMT1/GLP |
|
||
| GSK343 | Methyltransferase | EZH2 |
|
||
| GSK-J1 | Lysine Demethylase | KDM6B/JMJD3, KDM6A/UTX, KDM5B/JARID1B | GSK-J2 (GSK-J5) |
|
|
| IOX2 | 2OG | PHD2 |
|
||
| IOX1 | 2OG | Pan-KDM |
|
||
| PFI-1 | Bromodomains | BRD2, BRD3, BRD4, BRDT |
|
||
| UNC0638 | Methyltransferase | EHMT2/G9a, EHMT1/GLP | UNC0737 |
|
|
| (+)-JQ1 | Bromodomains | BRD2, BRD3, BRD4, BRDT | (-)-JQ1 |
|
|
| MS023 | Methyltransferase | PRMT1, PRMT3, CARM1, PRMT6, PRMT8 | MS094 |
|
|
| MS049 | Methyltransferase | CARM1, PRMT6 | MS049N |
|
|
| NVS-CECR2-1 | Bromodomains | CECR2 | NVS-CECR2-C |
|
1 µM |
| I-BRD9 | Bromodomains | BRD9 |
|
||
| BI-9564 | Bromodomains | BRD9, BRD7 |
|
||
| BAY-598 | Methyltransferase | SMYD2 | BAY-369 |
|
|
| GSK484 | Arginine deiminases | PAD4 | GSK106 |
|
|
| GSK2801 | Bromodomains | BAZ2A, BAZ2B | GSK8573 |
|
|
| LP99 | Bromodomains | BRD9, BRD7 | 2S,3R-enantiomer |
|
|
| NI-57 | Bromodomains | BRPF1, BRD1, BRPF3 |
|
1 µM | |
| PFI-4 | Bromodomains | BRPF1 |
|
1 µM | |
| OF-1 | Bromodomains | BRPF1, BRD1, BRPF3 |
|
<5 µM | |
| SGC707 | Methyltransferase | PRMT3 | XY1 |
|
|
| BAZ2-ICR | Bromodomains | BAZ2A, BAZ2B |
|
||
| OICR-9429 | WD40 repeat | WDR5 | OICR-0547 |
|
|
| GSK-LSD1 | Lysine Demethylase | KDM1A/LSD1 |
|
||
| LLY-507 (multiple off-targets) | Methyltransferase | SMYD2 | SGC705 |
|
|
| PFI-3 | Bromodomains | SMARCA2, PBRM1, SMARCA4 | PFI-3oMet |
|
|
| A-366 | Methyltransferase | EHMT1/GLP, EHMT2/G9a |
|
||
| UNC1999 | Methyltransferase | EZH2 | UNC2400 |
|
|
| (R)-PFI-2 | Methyltransferase | SETD7 | (S)-PFI-2 |
|
|
| SGC-CBP30 | Bromodomains | CREBBP, EP300 | BDOIA513 |
|
|
| I-CBP112 | Bromodomains | CREBBP, EP300 |
|
||
| SGC3027 | Methyltransferase | PRMT7 | SGC3027N |
|
|
| SGC-GAK-1 | Kinase | GAK | SGC-GAK-1N |
|
|
| SGC-AAK1-1 | Kinase | AAK1, BMP2K, BIKE | SGC-AAK1-1N |
|
|
| BI01383298 | Solute carriers | SLC13A5 | BI01372674 |
|
|
| L-Moses | Bromodomains | KAT2A, KAT2B | D-Moses |
|
|
| TH-257 | Kinase | LIMK1, LIMK2 | TH-263 |
|
|
| SKI-73 | Methyltransferase | CARM1 | SKI-73N |
|
|
| PFI-5 | Methyltransferase | SMYD2 | PFI-5N |
|
|
| BAY-6035 | Methyltransferase | SMYD3 | BAY-444 |
|
|
| GSK4027 | Bromodomains | KAT2A, KAT2B | GSK4028 |
|
|
| FM-381 | Kinase | JAK3 | FM-479 |
|
|
| BAY-850 | Bromodomains | ATAD2 | BAY-460 |
|
|
| GSK8814 | Bromodomains | ATAD2, ATAD2B | GSK8815 |
|
|
| GSK6853 | Bromodomains | BRPF1 | GSK9311 |
|
< 1 µM |
| LLY-283 | Methyltransferase | PRMT5 | LLY-284 |
|
|
| A-395 | WD40 repeat | EED | A-395N |
|
|
| TP-472 | Bromodomains | BRD9, BRD7 | TP-472N |
|
|
| TP-064 | Methyltransferase | CARM1 | TP-064N |
|
|
| BAY-299 | Bromodomains | TAF1, BRD1 | BAY-364 |
|
|
| NVS-PAK1-1 | Kinase | PAK1 | NVS-PAK1-C |
|
|
| GSK864 | Dehydrogenase | IDH1 | GSK990 |
|
|
| A-196 | Methyltransferase | SUV420H1, SUV420H2 | SGC2043 |
|
|
| GSK591 | Methyltransferase | PRMT5 | SGC2096 |
|
|
| MU1700 | Kinase | ALK1, ALK2 | MU1700NC |
|
|
| M4K2234 | Kinase | ALK1, ALK2 | M4K2234NC |
|
1 µM |
| SGC-UBD253 | UBD (ubiquitin binding domain) | HDAC6 | SGC-UBD253N |
|
|
| CK156 | Kinase | STK17A, DRAK1 | CKJB71 |
|
5 µM |
| PFI-7 | E3 ligase | GID4 | PFI-7N |
|
|
| MRIA9 | Kinase | SIK1, SIK2, SIK3 | MR7 |
|
10 µM |
| Homer | WD40 repeat | WDR5 | nc_WDR5 and nc_VHL |
|
1 µM |
| SGC-SMARCA-BRDVIII | Bromodomains | PB1(5), SMARCA2/4 | SGC-BRDVIII-NC |
|
10 µM |
| NR162 | Kinase | CASK | NR187 |
|
10 µM |
| PFI-6 | YEATS | MLLT1, MLLT3 | PFI-6N |
|
|
| SGC-CK2-1 | Kinase | CSNK2A1, CSNK2A2 | SGC-CK2-1N |
|
|
| NVS-MLLT-1 | YEATS | MLLT1, MLLT3 | NVS-iMLLT-C |
|
1 µM |
| SGC-STK17B-1 | Kinase | STK17B, DRAK2 | SGC-STK17B-1N |
|
|
| SGC-CLK-1 | Kinase | CLK1, CLK2, CLK4 | SGC-CLK-1N |
|
|
| SGC-CAMKK2-1 | Kinase | CAMKK1, CAMKK2 | SGC-CAMKK2-1N |
|
|
| SGC6870 | Methyltransferase | PRMT6 | SGC6870N |
|
|
| UNC6934 | Methyl Lysine Binder | NSD2-PWWP1 | UNC7145 |
|
|
| MU1210 | Kinase | CLK1, CLK2, CLK4, DYRK1A, DYRK1B, DYRK2 | MU140 |
|
1 µM |
| NVS-BPTF-1 | Bromodomains | BPTF | NVS-BPTF-C |
|
< 1 µM |
| VinSpinIn | Spindlin domains | Spin1 | VinSpinIC |
|
0.5 µM - 3 µM |
| TP-238 | Bromodomains | CECR2, BPTF | TP-422 |
|
< 2 µM |
| DDR-TRK-1 | Kinase | DDR, TRK | DDR-TRK-1N |
|
5 µM |
| BI-9321 | Methyl Lysine Binder | NSD3 | BI-9466 |
|
0.5 µM - 20 µM |
| MRK-740 | Methyltransferase | PRDM9 | MRK-740-NC |
|
3 µM |
| SGC-UBD1031 | UBD (ubiquitin binding domain) | USP16/HDAC6 | SGC-UBD1031N |
|
10 µM |
| UNC8732 | Methyl Lysine Binder | NSD2 | UNC8884 |
|
|
| OICR11029 | Transcription factor | BCL6 | OICR11600 |
|
|
| PFI-8 | YEATS | YEATS | PFI-8N |
|
|
| JA310 | Kinase | MST3, MST4 | JA262 |
|
< 1 µM |
| SGC-GSK3-1 | Kinase | GSK3 | SGC-CDKL5/GSK3-1N |
|
|
| SGC-CDKL5_GSK3 | Kinase | CDKL5, GSK3 | SGC-CDKL5/GSK3-1N |
|
|
| SGC-CAF382-1 | Kinase | CDKL5 | SGC-CAF268-1N |
|
≤ 100 nM |
| LIJTF500025 | Kinase | LIMK1, LIMK2 | LIJTF500120 |
|
< 1 µM |
| JA397 | Kinase | CDK14-18 | JA314 |
|
< 1 µM |
| SGC-PI5P4Kγ/MYLK4-1 | Kinase | PI5P4K gamma, MYLK4 | SGC-PI5P4Kγ/MYLK4-1N |
|
|
| SGC-CK2-2 | Kinase | CK2/CSNK2 | SGK-CK2-2N |
|
|
| MSC1186 | Kinase | SRPK | MSC5360 |
|
< 1 µM |
| CS640 | Kinase | CAMK1 | CS640s |
|
< 1 µM |
| MU1742 | Kinase | CK1δ, CK1ε | MU2027 |
|
|
| BAY-805 | USP (ubiquitin specific protease) | USP21 | BAY-728 |
|
|
| MRK-952 | Hydrolase | NUDT5 | MRK-952-NC |
|
|
| MRK-990 | Methyltransferase | PRMT9, PRMT5 | MRK-990-NC |
|
|
| SGC-PIKFYVE-1 | Kinase | PIKfyve | SGC-PIKFYVE-1N |
|