Participate

Participate in the Target 2035 Initiative

Participate

Whether you are in a company, a government institution, or academia, there are numerous ways for you to get involved.

At SGC, our Target 2035 mission to identify chemical or protein tools for all human proteins relies on diverse collaborations. We invite companies, government institutions, and academia to contribute to the mission. Participants can engage in research collaborations, funding initiatives, and resource sharing. By joining us, you’ll access cutting-edge technologies and a collaborative network dedicated to developing open-source tools to understand human biology and advance the discovery of new medicines.

Discover the many ways you can get involved.

    How to Participate

  • Protein Contribution Network

  • Open Benchmarking Challenges

  • MAINFRAME

  • Donate Chemical Probes

  • Membership: Become a Steering Partner

Our new initiative, the Protein Contribution Network, invites scientists from academia and industry to contribute purified proteins to support large-scale protein-ligand interaction screenings through Affinity Selection Mass Spectrometry (AS-MS) and DNA-encoded chemical libraries (DEL) assays, using industry-standard protocols. Allow the screening data to be shared with the world and, in turn, receive validated hits for your protein of interest.

Why contribute?

  • Advance hit-finding algorithms: Help build an extensive, high-quality protein-ligand interaction dataset that drives computational drug discovery efforts.
  • Contribute to Open Data: Democratize drug discovery by making it faster, more efficient, and more accessible through open science.
  • Foster Collaborative Opportunities: Donating your protein opens doors to exclusive collaborative options.

How to contribute?

Fill out our Protein Intake Form to get started, or visit our program page for full details. For any questions, contact proteins@thesgc.org

BEACON is a new partnership comprising leading benchmarking and critical assessment organizations. Target 2035 data will be contributed to BEACON, which will organize challenges to allow computational scientists to benchmark hit-finding algorithms in real-world settings, with experimental testing of model predictions. The initiative partners with leading open science efforts to design and host benchmarking challenges, including:

  • CACHE: Critical Assessment of Computational Hit-Finding Experiments
  • CASP: Critical Assessment of protein Structure Prediction
  • Target 2035 DREAM Challenges focused on protein–ligand binding predictions
  • OpenADMET focused on models of the safety and toxicity of small molecules

MAINFRAME is a new international network of open-source machine learning researchers, computational chemists, and data scientists. Membership is free and provides early access to curated datasets, experimental feedback, and a collaborative environment to test and benchmark your models. 

For more information visit https://aircheck.ai/mainframe 

Our Donated Chemical Probes program is a mechanism for chemical biologists to have their chemical probes vetted for quality by industry and academic experts and then included in a probe set that is shared widely. We invite scientists from academia and industry to donate their validated chemical probes to biomedical research community. Your contribution can accelerate disease understanding and therapeutic development.

Why donate?

  • Advance Science: Share your chemical probes with the global research community
  • Support Open Science: Enable free access to high quality research tools
  • Foster Innovation: Strengthen collaboration between academia and industry

How to donate?

Read detailed information here or reach out to us at frankfurt@thesgc.org 

Joining the SGC as an Organizational Member or Technology Partner offers the opportunity to influence and govern the overall direction of the consortium and its projects, including Target 2035, and to prioritize your projects within the SGC initiatives.

Organizational Membership: Organizations can become Members of the SGC by contributing €5 million over five years. This funding helps co-fund the overall project, provides real-time access to target progress and emerging data, ensures that SGC resources are directed toward your priority targets or areas, enables dedicated offline collaboration periods, and supports active collaborations between the SGC labs and Member organizations.

Technology Partners: Companies with an interest in collaborating on specific aspects of the project, such as computational methodologies or new experimental technologies, can join by contributing €2 million over five years. The Technology Partners will have open access to SGC proteins and expertise, the opportunity to collaborate with SGC scientists on projects of relevance to them, and join a large industry network that includes potential collaborators.

To explore partnership opportunities, discuss potential collaborations, or learn more about how you can contribute, please contact us at claudia.gordijo@thesgc.org