Frankfurt, Germany – January 20, 2026

The new multi-sector public-private partnership funded by the Innovative Health Initiative (IHI) brings together 18 partners across nine countries to generate large open, high-quality datasets of protein–ligand interactions and use them to train artificial intelligence (AI) models capable of predicting candidate molecules as suitable binders for thousands of human proteins.

• Experts across academia, industry, technology companies, and research organizations will collaborate over the next five years to generate open and accessible, high-quality, AI-ready protein-ligand data at scale as a public resource.

• With a budget of more than €60 million, the project aligns with IHI’s mission to foster international, cross-sectoral collaboration and advance medicine discovery by bringing the power of data science to hit identification technologies.

   

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Led by Pfizer and the Structural Genomics Consortium (SGC), LIGAND-AI consortium will interrogate thousands of proteins relevant to existing and unmet disease areas including rare, neurological, and oncological conditions.

Early drug discovery is a long, expensive, and uncertain process. Scientists spend years testing thousands of molecules to find just one that binds to a disease-related protein. LIGAND-AI aims to change this by combining advanced laboratory technologies with computational methods to create a seamless pipeline from experiment to prediction. The consortium will generate billions of data points using complementary screening technologies, enabling researchers worldwide to develop, train and benchmark AI models that predict molecular interactions.

“This project brings together scientists and companies from across disciplines within an open science ecosystem. It is heartening to see these diverse scientific communities coalesce around a common vision to generate and share valuable chemical data openly with the world,” said Aled Edwards, CEO of the Structural Genomics Consortium and project coordinator.

Beyond data generation, LIGAND-AI will foster an open discovery ecosystem by inviting the scientific community to co-develop and refine predictive models through open challenges and benchmarking campaigns. All data generated through LIGAND-AI will be shared according to FAIR principles, ensuring they are findable, accessible, interoperable, and reusable by the global scientific community. By integrating expertise in protein science, structural biology, chemistry, and machine learning, the project will build a dynamic network where experimental and computational discoveries evolve together, ensuring that progress is cumulative, transparent, and accessible.

By establishing a shared, open-science infrastructure for AI-driven drug discovery, LIGAND-AI will not only advance early-stage research but also train a new generation of interdisciplinary scientists fluent in both computation and experimentation. The project represents a major step toward the mission of Target 2035—to discover chemical modulators for every human protein by the year 2035. LIGAND-AI is a major milestone toward realizing this vision, catalyzing global collaboration, reducing fragmentation across sectors, and advancing data-driven discovery.

For more information about LIGAND-AI, visit http://ligand-ai.org/ 

For more information about Target 2035, visit www.target2035.net

Contact:

Structural Genomics Consortium

Sofia Melliou, Research Communications Specialist
sofia.melliou@thesgc.org

About  LIGAND-AI:

LIGAND-AI is a flagship project of the Target 2035 initiative. It is supported by the Innovative Health Initiative Joint Undertaking (IHI JU) under grant agreement No 101252959. The JU receives support from the European Union’s Horizon Europe research and innovative programme, COCIR, EFPIA, EuropaBio, MedTech Europe, Vaccines Europe, Enamine, and The Hospital for Sick Children. Views and opinions expressed are however, those of the author(s) only and do not necessarily reflect those of the aforementioned parties. Neither of the aforementioned parties can be held responsible for them.

The LIGAND-AI Consortium is formed by the following partners:

Structural Genomics Consortium, European Molecular Biology Laboratory, Goethe University Frankfurt, Universidade Estadual de Campinas, University College London, University Health Network, Vall d’Hebron Institute of Oncology (VHIO), Abcam Limited, AstraZeneca UK Limited, Chemspace LLC, Enamine Germany GmbH, IBM Research Israel – Science and Technology LTD, Novo Nordisk, Nuvisan ICB GmbH, Pfizer Inc, The Hospital for Sick Children in Toronto, Thermo Fisher Scientific GmbH, and Vernalis (R&D) Limited.