Opher Gileadi studied at the Hebrew University. He did his post-doc at Stanford, then led a research group at the Weizmann Institute. Opher has studied the biochemical basis of gene expression and of DNA repair, using a wide range of approaches including differential mRNA analysis in human trophoblast cells, studies of transcription factors using purified systems and yeast genetics, and single-molecule analyses of protein:DNA interactions.
At the SGC, Opher established the Biotechnology group, developing methods for high-throughput production of human proteins for crystallization. He now heads the Genome Integrity and Neurodegeneration group, which studies DNA repair proteins and on proteins associated with human genetic disease. Recent work includes structures of RecQ DNA helicases and DNA cross-link repair endonucleases, and biochemical characterization of genes mutated in Carpenter’s syndrome and congenital dyserythropoietic anemia. We are also developing methods to intervene with DNA repair using small molecules such as the new inhibitors of the Bloom DNA helicase.