The Kinase Chemogenomic Set by SGC at UNC
The Kinase Chemogenomic Set (KCGS) is a collection of narrow spectrum small molecule kinase inhibitors that has been assembled by the SGC-UNC to study the biology of dark kinases. We have recently updated to version 2.0 of the set. KCGSv2.0 is distributed by CancerTools.org, a non-profit community of cancer researchers, working together to accelerate cancer research.
KCGSv2.0 contains 295 kinase inhibitors sourced from eight pharma companies and academic laboratories with potent activity on 262 human kinases. Each inhibitor has been cross-screened across hundreds of kinases and only those meeting strict selectivity criteria are included in the set. An open-access scientific paper and supporting information describing KCGSv1.0 with details of the kinases covered and their use in cell-based assays has been published in International Journal of Molecular Sciences.