Pfizer in collaboration with the SGC have developed a handle PFI-E3H1 and a PEGylated analogue to show that the handle tolerates a substitution at the exit vector. These findings offers opportunities to synthesize proximity-inducing or degrader modalities.
A control (PFI-7N) has been made for the related probe PFI-7. We recommend incorporating the features of PFI-7N when designing negative controls for PROTACs with PFI-E3H1. Please also see the tab named 'References'.
