SGC-UBD1031

SGC-UBD1031 A probe with dual USP16-HDAC6 activity.

The probe and control may be requested here.

  • overview
  • selectivity profile
  • in vitro potency
  • cell based assay data
overview

SGC in collaboration with Dr Mark Lautens’ at the University of Toronto’s Department of Chemistry has developed the first chemical probe SGC-UBD1031 for the ubiquitin binding domain (UBD) of USP16. SGC-UBD1031 has equipotent affinity to HDAC6 UBD and it is recommended to be used in parallel with SGC-UBD253.

SGC-UBD1031 binds potently to USP16 UBD with KD = 48 nM (SPR), and in cells it inhibits the USP16-ISG15 interaction with EC50 = 1.7 micromolar (nanoBRET). 

SGC-UBD1031N is a closely related negative control with no activity in the nanoBRET assay up to 30 micromolar. 

properties
selectivity profile
in vitro potency
cell based assay data
references
pk properties
co-crystal structures
synthetic schemes
materials and methods
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