Genentech in collaboration with the SGC have discovered the first chemical probe, GNE-PROBE-1977, for human three-prime repair exonuclease 1 (TREX1).

GNE-PROBE-1977 is exquisitely selective against TREX2 as well as DEDDH proteins. Further, the probe has sub-micromolar potency in a THP-1 IFN reporter assay.

We recommend its use in cell assays at a dosage of 500 nM. Please do not exceed a dosage of 2 µM (2000 nM).

*Please note that the probe is not recommended for use in animals. (It is predicted to have high clearance.)