SGC-NSP2hel-1

SGC-NSP2hel-1 A chemical probe for CHIKV nsp2 helicase.

  • overview
  • selectivity profile
  • in vitro potency
  • cell based assay data
overview

SGC-UNC has developed a chemical probe for CHIKV nsp2 helicase (SGC-NSP2hel-1). The chemical probe SGC-NSP2hel-1 potently inhibits viral replication, nsP2hel ATPase activity, and dsRNA unwinding, while the (S)- enantiomer was >100-fold less active.

 

properties
selectivity profile

 

in vitro potency

 

cell based assay data

 

 

references
pk properties
co-crystal structures
synthetic schemes
materials and methods
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