Huntington's Disease Lab at SGC

Huntington's Disease Lab at SGC

Lead by : Rachel Harding

Huntington's Disease Lab at SGC

The Harding Lab

The Harding lab uses structural biology, protein biochemistry and chemical biology to study the molecular mechanisms of pathology of repeat expansion disorders, with a primary focus on Huntington’s disease. We collaborate with both academic and industry experts from around the world to uncover novel aspects of disease biology and identify new therapeutic targets.

Group Members

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Having just completed her Ph.D. studies at York University, Esther hails from the world of structural mass spectrometry and hydrogen-deuterium exchange. Her new focus will center on biophysical characterization of novel Huntingtin interactors in the lab of Dr. Rachel Harding.

Esther Wolf

Post Doctoral Fellow
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Manisha is a PhD student under the co-supervision of C. Arrowsmith and R. Harding. Her research focuses on studying Huntingtin-RNA interactions in relevant cell models of Huntington’s disease, employing approaches from molecular, cell and structural biology.

Manisha Yadav

Graduate Student
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Rebeka Fanti joined SGC Toronto in January 2023 as a PhD student in the Molecular Genetics Department at the University of Toronto. She is exploring the potential application of macrocyclic peptides as tools to investigate the role of the Huntingtin protein in the cell.

Rebeka Fanti

Graduate Student
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Samira is a PhD student at the University of Toronto, co-supervised by Drs. R. Harding and A. Edwards. She completed a BSc in Genetics and MSc in Nanobiotechnology at the University of Tehran. Her current research focuses on a genetic neurodegenerative disorder.

Samira Sadeghi

Graduate Student
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Ailin joined the Harding Lab in September 2024 as a PhD student in the Pharmacology department at the University of Toronto. She completed her BSc in Biology at York University.

Ailin Heidari

Graduate Student
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Rocher is an MSc student in the Pharmacology & Toxicology Department at the University of Toronto. She graduated with a BSc in Honours Pharmacology from McGill University where she performed biochemical research on Alzheimer’s Disease. Her new focus will be on the biophysics and structural analysis of proteins involved in Huntington’s Disease.

Rocher Leung

Graduate Student
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Renu graduated with an MS in Chemical Engineering from Michigan Technological University. Currently, she is working on characterizing protein-protein interactions and detection of protein complexes as a means of understanding disease pathways.

Renu Chandrasekaran

Lab Technician
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Elisa graduated from Fleming College with an advanced diploma in Biotechnology. She has over ten years of experience producing recombinant proteins for various projects within the SGC.

Elisa Gibson

Lab Technician
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Caroline is a second-year undergrad specializing in Biological Chemistry at the University of Toronto Mississauga. Her current research focuses on assay development to study protein-ligand interactions.

Caroline Lyu

Summer Student
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Kieran joined the Harding lab in his final undergraduate year to research the cancer-linked protein MAGEA3. After his thesis, he continued studying MAGEA3, focusing on solving ligand bound co-crystal structures of MAGEA3 and compounds derived from the SGC’s AS-MS hit identification platform.

Kieran O'Brien

Research Assistant
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Swati graduated with a PhD from the Indian Institute of Science, specializing in biomolecular NMR and biophysics. She then went on to a postdoctoral fellowship at Vanderbilt University to gain expertise in cryo-EM. After a short stint at IIT Delhi setting up and running a national Cryo-EM facility, Swati has joined the Harding lab with a fellowship awarded by the Hereditary Disease Foundation to study novel therapeutic protein targets for Huntington's disease. 

Swati Balakrishnan

Research Associate
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Meaghan joined the Harding Lab as an MSc student in the Department of Pharmaceutical Sciences at the University of Toronto. She graduated with an HBSc in Fundamental Genetics and its Applications at the University of Toronto.

Meaghan Thompson

Graduate Student

Group Alumni

  • Eli Landau, Undergraduate Project Student [2024]
  • Morgan Cheng, Undergraduate Project Student [2024]
  • Ethan Sabusco, Summer Student [2025]
  • Alex Trainor, Summer Student [2025]
  • Inouée Jousselin, Summer Student [2025]
  • Ella Sussman, Summer Student [2025]
  • David Zhuang, Summer Student [2025]