Frank von Delft

Principal Investigator

University of Oxford

Frank has been head of the PX group since the start of the SGC in 2004, focussing on methodology and high-throughput techniques for protein crystallography. In late 2012 he joined the Diamond Light Source synchrotron as head of beamline I04-1. In this role he is working to make Fragment Screening by X-ray Crystallography an easily accessible and routine experiment for both academic and industrial users.

Frank received his undergraduate degree from the University of the Free State (Bloemfontein, South Africa), and gained his PhD in protein crystallography under Tom Blundell at Cambridge (UK). He has also worked as a postdoc in San Diego (academically at Scripps in the JCSG, industrially at Syrrx in its pre-Takeda days). He is a visiting professor at the Biochemistry Department of the University of Johannesburg.

Research Areas

The context of our research is the SGC pursuit of structures and chemical probes[1]. Our group collaborates closely within the whole SGC, enabling massively parallel crystallization of all purified proteins using our general-access infrastructure, and ensuring that crystals are solved by in-house testing, synchrotron data collection and rapid structure solution – an ideal environment for methods development. Our scientific focus is how crystallography can truly transform cost and efficiency in protein-targeted chemistry – possible in principle, but difficult to achieve in practice. We thus address the methodology of: (1) ease-of-use and accessibility for all steps in crystallography, from crystallization to structure solution; and hence, (2) how to generate ligand-bound structures reliably and rapidly, to allow crystallography to become a truly routine assay for ligand binding. The PX group offers opportunities both in structure projects, to gain extensive experience rapidly; and in developing methodologies, including: characterization of protein quality; calculating protein crystallizability; crystal optimization; non-manual harvesting of crystals; serial optimized data collection; massively parallelized structure solution; ligand solubility and crystal soaking protocols.

Publications

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Cox, OB; Krojer, T; Collins, P; Monteiro, O; Talon, R; Bradley, A; Fedorov, O; Amin, J; Marsden, BD; Spencer, J; von Delft, F; Brennan, PE;
Chemical Science. 2016 7:2322-2330. doi: 10.1039/c5sc03115j
PMID: 29910922

Lessons from ten years of crystallization experiments at the SGC.
Ng, JT; Dekker, C; Reardon, P; von Delft, F;
Acta Crystallographica. Section d, Structural Biology. 2016 72:224-235. doi: 10.1107/S2059798315024687
PMID: 26894670

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.
Chaikuad, A; Knapp, S; von Delft, F;
Acta Crystallographica Section D: Biological Crystallography. 2015 71:1627-1639. doi: 10.1107/S1399004715007968
PMID: 26249344

Using textons to rank crystallization droplets by the likely presence of crystals.
Ng, JT; Dekker, C; Kroemer, M; Osborne, M; von Delft, F;
Acta Crystallographica Section D: Biological Crystallography. 2014 70:2702-2718. doi: 10.1107/S1399004714017581
PMID: 25286854

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Chowdhury, R; Sekirnik, R; Brissett, NC; Krojer, T; Ho, CH; Ng, SS; Clifton, IJ; Ge, W; Kershaw, NJ; Fox, GC; Muniz, JR; Vollmar, M; Phillips, C; Pilka, ES; Kavanagh, KL; von Delft, F; Oppermann, U; McDonough, MA; Doherty, AJ; Schofield, CJ;
Nature. 2014 510:422-426. doi: 10.1038/nature13263
PMID: 24814345

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Chowdhury, R; Sekirnik, R; Brissett, NC; Krojer, T; Ho, C-H; Ng, SS; Clifton, IJ; Ge, W; Kershaw, NJ; Fox, GC; Muniz, JRC; Vollmar, M; Phillips, C; Pilka, ES; Kavanagh, KL; von Delft, F; Oppermann, U; McDonough, MA; Doherty, AJ; Schofield, CJ;
Nature. 2014 510:422-426. doi: 10.1038/nature13263
PMID: 24814345

Squeezing the most from every crystal: the fine details of data collection.
Krojer, T; Pike, ACW; von Delft, F;
Acta Crystallographica Section D: Biological Crystallography. 2013 69:1303-1313. doi: 10.1107/S0907444913013280
PMID: 23793157

2018

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
Keedy, DA; Hill, ZB; Biel, JT; Kang, E; Rettenmaier, TJ; Brandão-Neto, J; Pearce, NM; von Delft, F; Wells, JA; Fraser, JS;
eLife. 2018 7:-. doi: 10.7554/eLife.36307
PMID: 29877794

Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.
Bowkett, D; Talon, R; Tallant, C; Schofield, C; von Delft, F; Knapp, S; Bruton, G; Brennan, PE;
ChemMedChem. 2018 13:1051-1057. doi: 10.1002/cmdc.201800030
PMID: 29578648

Diamond, XChem and CCP-CompMedChem: Creating user-focused tools and workflows for structure-based drug design
Bradley, A; Skyner, R; von Delft, F;
ACS National Meeting Book of Abstracts. 2018 255:-. doi:
PMID:

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.
Zhang, D; Markoulides, MS; Stepanovs, D; Rydzik, AM; El-Hussein, A; Bon, C; Kamps, JJAG; Umland, K-D; Collins, PM; Cahill, ST; Wang, DY; von Delft, F; Brem, J; McDonough, MA; Schofield, CJ;
Bioorganic and Medicinal Chemistry. 2018 26:2928-2936. doi: 10.1016/j.bmc.2018.02.043
PMID: 29655609

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.
Zheng, Y; Sethi, R; Mangala, LS; Taylor, C; Goldsmith, J; Wang, M; Masuda, K; Karaminejadranjbar, M; Mannion, D; Miranda, F; Herrero-Gonzalez, S; Hellner, K; Chen, F; Alsaadi, A; Albukhari, A; Fotso, DC; Yau, C; Jiang, D; Pradeep, S; Rodriguez-Aguayo, C; Lopez-Berestein, G; Knapp, S; Gray, NS; Campo, L; Myers, KA; Dhar, S; Ferguson, D; Bast, RC; Sood, AK; von Delft, F; Ahmed, AA;
Nature Communications. 2018 9:476-. doi: 10.1038/s41467-017-02811-7
PMID: 29396402

Where is crystallography going?
Grimes, JM; Hall, DR; Ashton, AW; Evans, G; Owen, RL; Wagner, A; McAuley, KE; von Delft, F; Orville, AM; Sorensen, T; Walsh, MA; Ginn, HM; Stuart, DI;
Acta Crystallographica. Section d, Structural Biology. 2018 74:152-166. doi: 10.1107/S2059798317016709
PMID: 29533241

CCP4i2: the new graphical user interface to the CCP4 program suite.
Potterton, L; Agirre, J; Ballard, C; Cowtan, K; Dodson, E; Evans, PR; Jenkins, HT; Keegan, R; Krissinel, E; Stevenson, K; Lebedev, A; McNicholas, SJ; Nicholls, RA; Noble, M; Pannu, NS; Roth, C; Sheldrick, G; Skubak, P; Turkenburg, J; Uski, V; von Delft, F; Waterman, D; Wilson, K; Winn, M; Wojdyr, M;
Acta Crystallographica. Section d, Structural Biology. 2018 74:68-84. doi: 10.1107/S2059798317016035
PMID: 29533233

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.
Delbart, F; Brams, M; Gruss, F; Noppen, S; Peigneur, S; Boland, S; Chaltin, P; Brandao-Neto, J; von Delft, F; Touw, WG; Joosten, RP; Liekens, S; Tytgat, J; Ulens, C;
Journal of Biological Chemistry. 2018 293:2534-2545. doi: 10.1074/jbc.M117.815316
PMID: 29237730

2017

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.
Bradley, AR; Echalier, A; Fairhead, M; Strain-Damerell, C; Brennan, P; Bullock, AN; Burgess-Brown, NA; Carpenter, EP; Gileadi, O; Marsden, BD; Lee, WH; Yue, W; Bountra, C; von Delft, F;
Essays in Biochemistry. 2017 61:495-503. doi: 10.1042/EBC20170051
PMID: 29118096

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
McIntyre, PJ; Collins, PM; Vrzal, L; Birchall, K; Arnold, LH; Mpamhanga, C; Coombs, PJ; Burgess, SG; Richards, MW; Winter, A; Veverka, V; Delft, FV; Merritt, A; Bayliss, R;
ACS Chemical Biology. 2017 12:2906-2914. doi: 10.1021/acschembio.7b00537
PMID: 29045126

Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin.
Harding RJ, Ferreira de Freitas R, Collins PM, Franzoni I, Ravichandran M, Ouyang H, Juarez-Ornelas KA, Lautens M, Schapira M, von Delft F, Santhakumar V, Arrowsmith CH
J. Med. Chem.. 2017 . doi: 10.1021/acs.jmedchem.7b00933
PMID: 29019676

Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.
Foley, DJ; Craven, PGE; Collins, PM; Doveston, RG; Aimon, A; Talon, R; Churcher, I; von Delft, F; Marsden, SP; Nelson, A;
Chemistry - A European Journal. 2017 23:15227-15232. doi: 10.1002/chem.201704169
PMID: 28983993

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Pearce, NM; Krojer, T; Bradley, AR; Collins, P; Nowak, RP; Talon, R; Marsden, BD; Kelm, S; Shi, J; Deane, CM; von Delft, F;
Nature Communications. 2017 8:15123-. doi: 10.1038/ncomms15123
PMID: 28436492

Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites.
Pearce, NM; Bradley, AR; Krojer, T; Marsden, BD; Deane, CM; von Delft, F;
Structural Dynamics. 2017 4:032104-. doi: 10.1063/1.4974176
PMID: 28345007

Gentle, fast and effective crystal soaking by acoustic dispensing.
Collins, PM; Ng, JT; Talon, R; Nekrosiute, K; Krojer, T; Douangamath, A; Brandao-Neto, J; Wright, N; Pearce, NM; von Delft, F;
Acta Crystallographica. Section d, Structural Biology. 2017 73:246-255. doi: 10.1107/S205979831700331X
PMID: 28291760

Proper modelling of ligand binding requires an ensemble of bound and unbound states.
Pearce, NM; Krojer, T; von Delft, F;
Acta Crystallographica. Section d, Structural Biology. 2017 73:256-266. doi: 10.1107/S2059798317003412
PMID: 28291761

The XChemExplorer graphical workflow tool for routine or large-scale protein-ligand structure determination.
Krojer, T; Talon, R; Pearce, N; Collins, P; Douangamath, A; Brandao-Neto, J; Dias, A; Marsden, B; von Delft, F;
Acta Crystallographica. Section d, Structural Biology. 2017 73:267-278. doi: 10.1107/S2059798316020234
PMID: 28291762

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Dixon-Clarke, SE; Shehata, SN; Krojer, T; Sharpe, TD; von Delft, F; Sakamoto, K; Bullock, AN;
Biochemical Journal. 2017 474:699-713. doi: 10.1042/BCJ20160941
PMID: 28057719

2016

Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome.
Faheem, M; Martins-de-Sa, D; Vidal, JFD; Álvares, ACM; Brandão-Neto, J; Bird, LE; Tully, MD; von Delft, F; Souto, BM; Quirino, BF; Freitas, SM; Barbosa, JARG;
Scientific Reports. 2016 6:38031-. doi: 10.1038/srep38031
PMID: 27934875

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
Cox, OB; Krojer, T; Collins, P; Monteiro, O; Talon, R; Bradley, A; Fedorov, O; Amin, J; Marsden, BD; Spencer, J; von Delft, F; Brennan, PE;
Chemical Science. 2016 7:2322-2330. doi: 10.1039/c5sc03115j
PMID: 29910922

An overview of heavy-atom derivatization of protein crystals.
Pike, ACW; Garman, EF; Krojer, T; von Delft, F; Carpenter, EP;
Acta Crystallographica. Section d, Structural Biology. 2016 72:303-318. doi: 10.1107/S2059798316000401
PMID: 26960118

Lessons from ten years of crystallization experiments at the SGC.
Ng, JT; Dekker, C; Reardon, P; von Delft, F;
Acta Crystallographica. Section d, Structural Biology. 2016 72:224-235. doi: 10.1107/S2059798315024687
PMID: 26894670

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
Bavetsias, V; Lanigan, RM; Ruda, GF; Atrash, B; McLaughlin, MG; Tumber, A; Mok, NY; Le Bihan, Y-V; Dempster, S; Boxall, KJ; Jeganathan, F; Hatch, SB; Savitsky, P; Velupillai, S; Krojer, T; England, KS; Sejberg, J; Thai, C; Donovan, A; Pal, A; Scozzafava, G; Bennett, JM; Kawamura, A; Johansson, C; Szykowska, A; Gileadi, C; Burgess-Brown, NA; von Delft, F; Oppermann, U; Walters, Z; Shipley, J; Raynaud, FI; Westaway, SM; Prinjha, RK; Fedorov, O; Burke, R; Schofield, CJ; Westwood, IM; Bountra, C; Müller, S; van Montfort, RLM; Brennan, PE; Blagg, J;
Journal of Medicinal Chemistry. 2016 59:1388-1409. doi: 10.1021/acs.jmedchem.5b01635
PMID: 26741168

2015

WONKA: objective novel complex analysis for ensembles of protein-ligand structures.
Bradley, AR; Wall, ID; von Delft, F; Green, DVS; Deane, CM; Marsden, BD;
Journal of Computer-Aided Molecular Design. 2015 29:963-973. doi: 10.1007/s10822-015-9866-z
PMID: 26387008

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.
Tsoumpra, MK; Muniz, JR; Barnett, BL; Kwaasi, AA; Pilka, ES; Kavanagh, KL; Evdokimov, A; Walter, RL; Von Delft, F; Ebetino, FH; Oppermann, U; Russell, RGG; Dunford, JE;
BONE. 2015 81:478-486. doi: 10.1016/j.bone.2015.08.020
PMID: 26318908

Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
Rouka, E; Simister, PC; Janning, M; Kumbrink, J; Konstantinou, T; Muniz, JRC; Joshi, D; O'Reilly, N; Volkmer, R; Ritter, B; Knapp, S; von Delft, F; Kirsch, KH; Feller, SM;
Journal of Biological Chemistry. 2015 290:25275-25292. doi: 10.1074/jbc.M115.637207
PMID: 26296892

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.
Chaikuad, A; Knapp, S; von Delft, F;
Acta Crystallographica Section D: Biological Crystallography. 2015 71:1627-1639. doi: 10.1107/S1399004715007968
PMID: 26249344

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.
Froese, DS; Michaeli, A; McCorvie, TJ; Krojer, T; Sasi, M; Melaev, E; Goldblum, A; Zatsepin, M; Lossos, A; Álvarez, R; Escribá, PV; Minassian, BA; von Delft, F; Kakhlon, O; Yue, WW;
Human Molecular Genetics. 2015 24:5667-5676. doi: 10.1093/hmg/ddv280
PMID: 26199317

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Riemersma, M; Froese, DS; van Tol, W; Engelke, UF; Kopec, J; van Scherpenzeel, M; Ashikov, A; Krojer, T; von Delft, F; Tessari, M; Buczkowska, A; Swiezewska, E; Jae, LT; Brummelkamp, TR; Manya, H; Endo, T; van Bokhoven, H; Yue, WW; Lefeber, DJ;
Cell Chemistry Biology. 2015 22:1643-1652. doi: 10.1016/j.chembiol.2015.10.014
PMID: 26687144

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.
Pike, ACW; Gomathinayagam, S; Swuec, P; Berti, M; Zhang, Y; Schnecke, C; Marino, F; von Delft, F; Renault, L; Costa, A; Gileadi, O; Vindigni, A;
Proceedings of the National Academy of Sciences. 2015 112:4286-4291. doi: 10.1073/pnas.1417594112
PMID: 25831490

Status of the crystallography beamlines at Diamond Light Source
Allan, DR; Collins, SP; Evans, G; Hall, D; McAuley, K; Owen, RL; Sorensen, T; Tang, CC; von Delft, F; Wagner, A; Wilhelm, H;
European Physical Journal Plus. 2015 130:-. doi: 10.1140/epjp/i2015-15056-x
PMID:

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
Kerr, G; Sheldon, H; Chaikuad, A; Alfano, I; von Delft, F; Bullock, AN; Harris, AL;
Angiogenesis. 2015 18:209-217. doi: 10.1007/s10456-014-9457-y
PMID: 25557927

Application of in situ diffraction in high-throughput structure determination platforms.
Aller, P; Sanchez-Weatherby, J; Foadi, J; Winter, G; Lobley, CMC; Axford, D; Ashton, AW; Bellini, D; Brandao-Neto, J; Culurgioni, S; Douangamath, A; Duman, R; Evans, G; Fisher, S; Flaig, R; Hall, DR; Lukacik, P; Mazzorana, M; McAuley, KE; Mykhaylyk, V; Owen, RL; Paterson, NG; Romano, P; Sandy, J; Sorensen, T; von Delft, F; Wagner, A; Warren, A; Williams, M; Stuart, DI; Walsh, MA;
Methods in Molecular Biology. 2015 1261:233-253. doi: 10.1007/978-1-4939-2230-7_13
PMID: 25502203

2014

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
England, KS; Tumber, A; Krojer, T; Scozzafava, G; Ng, SS; Daniel, M; Szykowska, A; Che, K; von Delft, F; Burgess-Brown, NA; Kawamura, A; Schofield, CJ; Brennan, PE;
MedChemComm. 2014 5:1879-1886. doi: 10.1039/C4MD00291A
PMID: 26682034

Using textons to rank crystallization droplets by the likely presence of crystals.
Ng, JT; Dekker, C; Kroemer, M; Osborne, M; von Delft, F;
Acta Crystallographica Section D: Biological Crystallography. 2014 70:2702-2718. doi: 10.1107/S1399004714017581
PMID: 25286854

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Chowdhury, R; Sekirnik, R; Brissett, NC; Krojer, T; Ho, C-H; Ng, SS; Clifton, IJ; Ge, W; Kershaw, NJ; Fox, GC; Muniz, JRC; Vollmar, M; Phillips, C; Pilka, ES; Kavanagh, KL; von Delft, F; Oppermann, U; McDonough, MA; Doherty, AJ; Schofield, CJ;
Nature. 2014 510:422-426. doi: 10.1038/nature13263
PMID: 24814345

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Chowdhury, R; Sekirnik, R; Brissett, NC; Krojer, T; Ho, CH; Ng, SS; Clifton, IJ; Ge, W; Kershaw, NJ; Fox, GC; Muniz, JR; Vollmar, M; Phillips, C; Pilka, ES; Kavanagh, KL; von Delft, F; Oppermann, U; McDonough, MA; Doherty, AJ; Schofield, CJ;
Nature. 2014 510:422-426. doi: 10.1038/nature13263
PMID: 24814345

2013

Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.
Ferguson, FM; Fedorov, O; Chaikuad, A; Philpott, M; Muniz, JRC; Felletar, I; von Delft, F; Heightman, T; Knapp, S; Abell, C; Ciulli, A;
Journal of Medicinal Chemistry. 2013 56:10183-10187. doi: 10.1021/jm401582c
PMID: 24304323

Structural insights into functional overlapping and differentiation among myosin V motors
Nascimento, AFZ; Trindade, DM; Tonoli, CCC; De Giuseppe, PO; Assis, LHP; Honorato, RV; Deoliveira, PSL; Mahajan, P; Burgess-Brown, NA; Von Delft, F; Larson, RE; Murakami, MT;
Journal of Biological Chemistry. 2013 288:34131-34145. doi: 10.1074/jbc.M113.507202
PMID:

Squeezing the most from every crystal: the fine details of data collection.
Krojer, T; Pike, ACW; von Delft, F;
Acta Crystallographica Section D: Biological Crystallography. 2013 69:1303-1313. doi: 10.1107/S0907444913013280
PMID: 23793157

Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases.
Muniz, JRC; Guo, K; Kershaw, NJ; Ayinampudi, V; von Delft, F; Babon, JJ; Bullock, AN;
Journal of Molecular Biology. 2013 425:3166-3177. doi: 10.1016/j.jmb.2013.06.015
PMID: 23806657

Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Froese, DS; Forouhar, F; Tran, TH; Vollmar, M; Kim, YS; Lew, S; Neely, H; Seetharaman, J; Shen, Y; Xiao, R; Acton, TB; Everett, JK; Cannone, G; Puranik, S; Savitsky, P; Krojer, T; Pilka, ES; Kiyani, W; Lee, WH; Marsden, BD; von Delft, F; Allerston, CK; Spagnolo, L; Gileadi, O; Montelione, GT; Oppermann, U; Yue, WW; Tong, L;
Structure. 2013 21:1182-1192. doi: 10.1016/j.str.2013.05.001
PMID: 23791943

Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.
Shafqat, N; Muniz, JRC; Pilka, ES; Papagrigoriou, E; von Delft, F; Oppermann, U; Yue, WW;
Biochemical Journal. 2013 452:27-36. doi: 10.1042/BJ20121580
PMID: 23425511

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
Canning, P; Cooper, CDO; Krojer, T; Murray, JW; Pike, ACW; Chaikuad, A; Keates, T; Thangaratnarajah, C; Hojzan, V; Ayinampudi, V; Marsden, BD; Gileadi, O; Knapp, S; von Delft, F; Bullock, AN;
Journal of Biological Chemistry. 2013 288:7803-7814. doi: 10.1074/jbc.M112.437996
PMID: 23349464

2012

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.
Chaikuad, A; Alfano, I; Kerr, G; Sanvitale, CE; Boergermann, JH; Triffitt, JT; von Delft, F; Knapp, S; Knaus, P; Bullock, AN;
Journal of Biological Chemistry. 2012 287:36990-36998. doi: 10.1074/jbc.M112.365932
PMID: 22977237

Structural basis for ASPP2 recognition by the tumor suppressor p73.
Canning, P; von Delft, F; Bullock, AN;
Journal of Molecular Biology. 2012 423:515-527. doi: 10.1016/j.jmb.2012.08.005
PMID: 22917970

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
Rose, NR; Woon, ECY; Tumber, A; Walport, LJ; Chowdhury, R; Li, XS; King, ONF; Lejeune, C; Ng, SS; Krojer, T; Chan, MC; Rydzik, AM; Hopkinson, RJ; Che, KH; Daniel, M; Strain-Damerell, C; Gileadi, C; Kochan, G; Leung, IKH; Dunford, J; Yeoh, KK; Ratcliffe, PJ; Burgess-Brown, N; von Delft, F; Muller, S; Marsden, B; Brennan, PE; McDonough, MA; Oppermann, U; Klose, RJ; Schofield, CJ; Kawamura, A;
Journal of Medicinal Chemistry. 2012 55:6639-6643. doi: 10.1021/jm300677j
PMID: 22724510

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.
Chaikuad, A; Pilka, ES; De Riso, A; von Delft, F; Kavanagh, KL; Vénien-Bryan, C; Oppermann, U; Yue, WW;
BMC Structural Biology. 2012 12:14-. doi: 10.1186/1472-6807-12-14
PMID: 22720794

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.
Froese, DS; Krojer, T; Wu, X; Shrestha, R; Kiyani, W; von Delft, F; Gravel, RA; Oppermann, U; Yue, WW;
Biochemistry. 2012 51:5083-5090. doi: 10.1021/bi300150y
PMID: 22642810

On the need for an international effort to capture, share and use crystallization screening data
Newman, J; Bolton, EE; Müller-Dieckmann, J; Fazio, VJ; Gallagher, DT; Lovell, D; Luft, JR; Peat, TS; Ratcliffe, D; Sayle, RA; Snell, EH; Taylor, K; Vallotton, P; Velanker, S; von Delft, F;
Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2012 68:253-258. doi: 10.1107/S1744309112002618
PMID: 22442216

Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.
Levisson, M; Han, GW; Deller, MC; Xu, Q; Biely, P; Hendriks, S; Ten Eyck, LF; Flensburg, C; Roversi, P; Miller, MD; McMullan, D; von Delft, F; Kreusch, A; Deacon, AM; van der Oost, J; Lesley, SA; Elsliger, M-A; Kengen, SWM; Wilson, IA;
Proteins. 2012 80:1545-1559. doi: 10.1002/prot.24041
PMID: 22411095

2011

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.
Chaikuad, A; Froese, DS; Berridge, G; von Delft, F; Oppermann, U; Yue, WW;
Proceedings of the National Academy of Sciences. 2011 108:21028-21033. doi: 10.1073/pnas.1113921108
PMID: 22160680

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Kochan, G; Krojer, T; Harvey, D; Fischer, R; Chen, L; Vollmar, M; von Delft, F; Kavanagh, KL; Brown, MA; Bowness, P; Wordsworth, P; Kessler, BM; Oppermann, U;
Proceedings of the National Academy of Sciences. 2011 108:7745-7750. doi: 10.1073/pnas.1101262108
PMID: 21508329

Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.
Salah, E; Ugochukwu, E; Barr, AJ; von Delft, F; Knapp, S; Elkins, JM;
Journal of Medicinal Chemistry. 2011 54:2359-2367. doi: 10.1021/jm101506n
PMID: 21417343

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.
Chen, D; Vollmar, M; Rossi, MN; Phillips, C; Kraehenbuehl, R; Slade, D; Mehrotra, PV; von Delft, F; Crosthwaite, SK; Gileadi, O; Denu, JM; Ahel, I;
Journal of Biological Chemistry. 2011 286:13261-13271. doi: 10.1074/jbc.M110.206771
PMID: 21257746

The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity.
Johansson, C; Roos, AK; Montano, SJ; Sengupta, R; Filippakopoulos, P; Guo, K; von Delft, F; Holmgren, A; Oppermann, U; Kavanagh, KL;
Biochemical Journal. 2011 433:303-311. doi: 10.1042/BJ20101286
PMID: 21029046

2010

Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
Leung, IKH; Krojer, TJ; Kochan, GT; Henry, L; von Delft, F; Claridge, TDW; Oppermann, U; McDonough, MA; Schofield, CJ;
Cell Chemistry Biology. 2010 17:1316-1324. doi: 10.1016/j.chembiol.2010.09.016
PMID: 21168767

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
Rellos, P; Pike, ACW; Niesen, FH; Salah, E; Lee, WH; von Delft, F; Knapp, S;
PLoS Biology. 2010 8:e1000426-. doi: 10.1371/journal.pbio.1000426
PMID: 20668654

2009

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
Kochan, G; Pilka, ES; von Delft, F; Oppermann, U; Yue, WW;
Journal of Molecular Biology. 2009 388:997-1008. doi: 10.1016/j.jmb.2009.03.064
PMID: 19345228

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
Bullock, AN; Russo, S; Amos, A; Pagano, N; Bregman, H; Debreczeni, JE; Lee, WH; von Delft, F; Meggers, E; Knapp, S;
PLoS ONE. 2009 4:e7112-. doi: 10.1371/journal.pone.0007112
PMID: 19841674

2007

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
Gileadi, O; Knapp, S; Lee, WH; Marsden, BD; Müller, S; Niesen, FH; Kavanagh, KL; Ball, LJ; von Delft, F; Doyle, DA; Oppermann, UCT; Sundström, M;
Journal of Structural and Functional Genomics. 2007 8:107-119. doi: 10.1007/s10969-007-9027-2
PMID: 17932789

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Ng, SS; Kavanagh, KL; McDonough, MA; Butler, D; Pilka, ES; Lienard, BMR; Bray, JE; Savitsky, P; Gileadi, O; von Delft, F; Rose, NR; Offer, J; Scheinost, JC; Borowski, T; Sundstrom, M; Schofield, CJ; Oppermann, U;
Nature. 2007 448:87-91. doi: 10.1038/nature05971
PMID: 17589501

Molecular replacement
Murshudov, G; Von Delft, F; Ballard, C;
Acta Crystallographica Section D: Biological Crystallography. 2007 64:-. doi: 10.1107/S0907444907058714
PMID: 18376450

2006

SDR goes SGC: A structural genomics initiative
Oppermann, U; Kavanagh, K; Guo, KD; Ng, S; Lukacik, P; Wu, XQ; Dubinina, E; Shafqat, N; Bray, J; Marsden, B; Sharma, S; Vedadi, M; von Delft, F; Sundstrom, M;
. 2006 12:235-241. doi:
PMID:

2005

Two-wavelength MAD phasing and radiation damage: a case study.
González, A; von Delft, F; Liddington, RC; Bakolitsa, C;
Journal of Synchrotron Radiation. 2005 12:285-291. doi: 10.1107/S0909049505003249
PMID: 15840912

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor.
Han, GW; Schwarzenbacher, R; Page, R; Jaroszewski, L; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Haugen, J; Hornsby, M; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Nigoghossian, E; Ouyang, J; Paulsen, J; Quijano, K; Reyes, R; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Xu, Q; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2005 58:971-975. doi: 10.1002/prot.20360
PMID: 15657930

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold.
Xu, Q; Schwarzenbacher, R; McMullan, D; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Hornsby, M; Jaroszewski, L; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Reyes, R; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2005 58:976-981. doi: 10.1002/prot.20364
PMID: 15651027

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution.
Arndt, JW; Schwarzenbacher, R; Page, R; Abdubek, P; Ambing, E; Biorac, T; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Godzik, A; Grittini, C; Grzechnik, SK; Hale, J; Hampton, E; Han, GW; Haugen, J; Hornsby, M; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Jaroszewski, L; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Nigoghossian, E; Ouyang, J; Peti, WS; Quijano, K; Reyes, R; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; White, A; Wolf, G; Xu, Q; Zagnitko, O; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2005 58:755-758. doi: 10.1002/prot.20336
PMID: 15624212

2004

Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution.
Miller, MD; Schwarzenbacher, R; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 57:213-217. doi: 10.1002/prot.20024
PMID: 15326606

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution.
Levin, I; Schwarzenbacher, R; McMullan, D; Abdubek, P; Ambing, E; Biorac, T; Cambell, J; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kreusch, A; Kuhn, P; Lesley, SA; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Reyes, R; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:629-633. doi: 10.1002/prot.20163
PMID: 15229897

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution.
Xu, Q; Schwarzenbacher, R; Page, R; Sims, E; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Cambell, J; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Quijano, K; Reyes, R; Rezezadeh, F; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:619-624. doi: 10.1002/prot.20164
PMID: 15229895

Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution.
McMullan, D; Schwarzenbacher, R; Jaroszewski, L; von Delft, F; Klock, HE; Vincent, J; Quijano, K; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshaghi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Koesema, E; Kreusch, A; Kuhn, P; Levin, I; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Reyes, R; Rezezadeh, F; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Lesley, SA; Wilson, IA;
Proteins. 2004 56:615-618. doi: 10.1002/prot.20139
PMID: 15229894

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution.
Jaroszewski, L; Schwarzenbacher, R; von Delft, F; McMullan, D; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Levin, I; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Reyes, R; Rezezadeh, F; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:611-614. doi: 10.1002/prot.20130
PMID: 15229893

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold.
Bakolitsa, C; Schwarzenbacher, R; McMullan, D; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:607-610. doi: 10.1002/prot.20138
PMID: 15229892

Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution.
Spraggon, G; Schwarzenbacher, R; Kreusch, A; McMullan, D; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kuhn, P; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Rezezadeh, F; Robb, A; Sims, E; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Lesley, SA; Wilson, IA;
Proteins. 2004 56:396-400. doi: 10.1002/prot.20084
PMID: 15211524

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution.
Schwarzenbacher, R; von Delft, F; Jaroszewski, L; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:392-395. doi: 10.1002/prot.20016
PMID: 15211523

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution.
Heine, A; Canaves, JM; von Delft, F; Brinen, LS; Dai, X; Deacon, AM; Elsliger, MA; Eshaghi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Guda, C; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McMullan, D; McPhillips, TM; Miller, MA; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Robb, A; Rodrigues, K; Schwarzenbacher, R; Selby, TL; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:387-391. doi: 10.1002/prot.20003
PMID: 15211522

From crystals to pdb: building a high throughput crystallography pipeline for strucural genomics
Chiu, H; Wolf, G; West, W; van den Bedem, H; Miller, MD; Zhang, Z; Morse, A; von Delft, F; Elsliger, MA; Grzechnik, SK;
Protein Science. 2004 13:184-184. doi:
PMID:

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution.
Levin, I; Schwarzenbacher, R; Page, R; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Campbell, J; Canaves, JM; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Quijano, K; Reyes, R; Rezezadeh, F; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:404-408. doi: 10.1002/prot.20090
PMID: 15211526

Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution.
Xu, Q; Schwarzenbacher, R; McMullan, D; von Delft, F; Brinen, LS; Canaves, JM; Dai, X; Deacon, AM; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:171-175. doi: 10.1002/prot.20129
PMID: 15162497

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution.
Santelli, E; Schwarzenbacher, R; McMullan, D; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Dai, X; Deacon, AM; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Rezezadeh, F; Robb, A; Sims, E; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 56:167-170. doi: 10.1002/prot.20120
PMID: 15162496

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution.
Spraggon, G; Schwarzenbacher, R; Kreusch, A; Lee, CC; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kuhn, P; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Lesley, SA; Wilson, IA;
Proteins. 2004 55:1078-1081. doi: 10.1002/prot.20034
PMID: 15146505

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution.
Schwarzenbacher, R; Jaroszewski, L; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 55:768-771. doi: 10.1002/prot.20029
PMID: 15103640

Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution.
Schwarzenbacher, R; Jaroszewski, L; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 55:759-763. doi: 10.1002/prot.10646
PMID: 15103638

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution.
Schwarzenbacher, R; Jaroszewski, L; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 55:474-478. doi: 10.1002/prot.20023
PMID: 15048837

Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution.
Schwarzenbacher, R; von Delft, F; Abdubek, P; Ambing, E; Biorac, T; Brinen, LS; Canaves, JM; Cambell, J; Chiu, H-J; Dai, X; Deacon, AM; DiDonato, M; Elsliger, M-A; Eshagi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Hampton, E; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; Levin, I; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Quijano, K; Robb, A; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Xu, Q; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 54:810-813. doi: 10.1002/prot.10647
PMID: 14997579

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution.
Erlandsen, H; Canaves, JM; Elsliger, M-A; von Delft, F; Brinen, LS; Dai, X; Deacon, AM; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Robb, A; Quijano, K; Schwarzenbacher, R; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 54:806-809. doi: 10.1002/prot.10631
PMID: 14997578

Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution.
Schwarzenbacher, R; Deacon, AM; Jaroszewski, L; Brinen, LS; Canaves, JM; Dai, X; Elsliger, M-A; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Nelson, MS; Ouyang, J; Page, R; Robb, A; Quijano, K; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; von Delft, F; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 54:801-805. doi: 10.1002/prot.10614
PMID: 14997577

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution.
Schwarzenbacher, R; von Delft, F; Canaves, JM; Brinen, LS; Dai, X; Deacon, AM; Elsliger, MA; Eshaghi, S; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Guda, C; Jaroszewski, L; Karlak, C; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McMullan, D; McPhillips, TM; Miller, MA; Miller, MD; Morse, A; Moy, K; Ouyang, J; Page, R; Robb, A; Rodrigues, K; Selby, TL; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 54:174-177. doi: 10.1002/prot.10594
PMID: 14705036

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution.
Page, R; Nelson, MS; von Delft, F; Elsliger, M-A; Canaves, JM; Brinen, LS; Dai, X; Deacon, AM; Floyd, R; Godzik, A; Grittini, C; Grzechnik, SK; Jaroszewski, L; Klock, HE; Koesema, E; Kovarik, JS; Kreusch, A; Kuhn, P; Lesley, SA; McMullan, D; McPhillips, TM; Miller, MD; Morse, A; Moy, K; Ouyang, J; Robb, A; Rodrigues, K; Schwarzenbacher, R; Spraggon, G; Stevens, RC; van den Bedem, H; Velasquez, J; Vincent, J; Wang, X; West, B; Wolf, G; Hodgson, KO; Wooley, J; Wilson, IA;
Proteins. 2004 54:157-161. doi: 10.1002/prot.10562
PMID: 14705032

2003

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites.
von Delft, F; Inoue, T; Saldanha, SA; Ottenhof, HH; Schmitzberger, F; Birch, LM; Dhanaraj, V; Witty, M; Smith, AG; Blundell, TL; Abell, C;
Structure. 2003 11:985-996. doi:
PMID: 12906829

The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode.
Ye, S; Von Delft, F; Brooun, A; Knuth, MW; Swanson, RV; McRee, DE;
Journal of Bacteriology. 2003 185:4144-4151. doi:
PMID: 12837789

2001

Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism.
Matak-Vinković, D; Vinković, M; Saldanha, SA; Ashurst, JL; von Delft, F; Inoue, T; Miguel, RN; Smith, AG; Blundell, TL; Abell, C;
Biochemistry. 2001 40:14493-14500. doi:
PMID: 11724562

Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction.
Saldanha, SA; Birch, LM; Webb, ME; Nabbs, BK; von Delft, F; Smith, AG; Abell, C;
Chemical Communications. 2001 :1760-1761. doi:
PMID: 12240302

The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily.
von Delft, F; Lewendon, A; Dhanaraj, V; Blundell, TL; Abell, C; Smith, AG;
Structure. 2001 9:439-450. doi:
PMID: 11377204

2000

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.
Pellegrini, L; Burke, DF; von Delft, F; Mulloy, B; Blundell, TL;
Nature. 2000 407:1029-1034. doi: 10.1038/35039551
PMID: 11069186

1998

Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing.
Albert, A; Dhanaraj, V; Genschel, U; Khan, G; Ramjee, MK; Pulido, R; Sibanda, BL; von Delft, F; Witty, M; Blundell, TL; Smith, AG; Abell, C;
Nature Structural and Molecular Biology. 1998 5:289-293. doi:
PMID: 9546220

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