Andreas Krämer graduated with a diploma in Chemistry from the University of Freiburg in 2012. During his PhD thesis at the University of Darmstadt (2013-2017), he focused on structural studies of bacterial members of the histone deacetylase superfamily (HDAC). After completing his PhD, he joined the group led by Stefan Knapp at the SGC Frankfurt as a postdoc, where he was funded by the Wellcome Trust, working on the structure-based development of selective and potent CaMK1D kinase inhibitors for the treatment of highly aggressive subtypes of breast cancer. Afterwards he worked at the Frankfurt Cancer Institute (FCI) as a staff scientist where, among other things, he was responsible for developing a comprehensive screening platform for kinases. In the beginning of 2022, Andreas became a principal investigator and is responsible for running the X-ray crystallography facility unit. His current research interests focus primarily on the structural biology of kinases and E3 ligases.
Dettenhöfer M, Tandara LN, Amrhein JA, Kurz CG, Schwalm MP, Mensing TE, Wahl LM, Krämer A, Gerninghaus J, Lenz C, Elson L, Berger BT, Schröder M, Saxena K, Müller S, Knapp S, Greco FA, Hanke T
ACS Med Chem Lett. 2025-11-19 . 16(11):2086-2096 .doi: 10.1021/acsmedchemlett.5c00479
PMID: 41256983Hank EC, D'Arcy-Evans ND, Scaletti ER, Benítez-Buelga C, Wallner O, Ortis F, Zhou K, Meng L, Del Prado A, Calvo P, Almlöf I, Wiita E, Nierlin K, Košenina S, Krämer A, Eddershaw A, Kehler M, Long M, Jemth AS, Dawson H, Stewart J, Dickey A, Astorga ME, Varga M, Homan EJ, Scobie M, Knapp S, Sastre L, Stenmark P, de Vega M, Helleday T, Michel M
RSC Chem Biol. 2025-11-6 . .doi: 10.1039/d4cb00323c
PMID: 41195166Kim Y, Lučić A, Lenz C, Farges F, Schwalm MP, Saxena K, Hanke T, Marples PG, Aschenbrenner JC, Fearon D, von Delft F, Krämer A, Knapp S
Commun Chem. 2025-6-14 . 8(1):185 .doi: 10.1038/s42004-025-01574-3
PMID: 40514378Raig ND, Surridge KJ, Sanz-Murillo M, Dederer V, Krämer A, Schwalm MP, Lattal NM, Elson L, Chatterjee D, Mathea S, Hanke T, Leschziner AE, Reck-Peterson SL, Knapp S
Sci Adv. 2025-6-4 . 11(23):eadt2050 .doi: 10.1126/sciadv.adt2050
PMID: 40465731Mandel S, Hanke T, Mathea S, Chatterjee D, Saraswati H, Berger BT, Schwalm MP, Yamamoto S, Tawada M, Takagi T, Ahmed M, Röhm S, Corrionero A, Alfonso P, Baena M, Elson L, Menge A, Krämer A, Pereira R, Müller S, Krause DS, Knapp S
ACS Chem Biol. 2025-4-14 . .doi: 10.1021/acschembio.5c00097
PMID: 40227881Sander P, Schwalm MP, Krämer A, Elson L, Rasch A, Masberg B, Selig R, Sievers-Engler A, Lämmerhofer M, Müller S, Knapp S, Albrecht W, Laufer SA
J Med Chem. 2024-12-17 . .doi: 10.1021/acs.jmedchem.4c02552
PMID: 39681301Zhu WF, Franz HM, Krämer A, Duman E, Empel C, Göbel MW, Koenigs RM, Knapp S, Hiesinger K, Proschak E, Hernandez-Olmos V
J Org Chem. 2024-10-23 . .doi: 10.1021/acs.joc.4c01622
PMID: 39438325Ong HW, Yang X, Smith JL, Taft-Benz S, Howell S, Dickmander RJ, Havener TM, Sanders MK, Brown JW, Couñago RM, Chang E, Krämer A, Moorman NJ, Heise M, Axtman AD, Drewry DH, Willson TM
Molecules. 2024-9-14 . 29(17): .doi: 10.3390/molecules29174158
PMID: 39275006Krämer A, Knapp S
Signal Transduct Target Ther. 2024-9-6 . 9(1):224 .doi: 10.1038/s41392-024-01935-9
PMID: 39237495Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T
J Med Chem. 2024-7-19 . .doi: 10.1021/acs.jmedchem.4c00411
PMID: 39028937