Andreas Krämer graduated with a diploma in Chemistry from the University of Freiburg in 2012. During his PhD thesis at the University of Darmstadt (2013-2017), he focused on structural studies of bacterial members of the histone deacetylase superfamily (HDAC). After completing his PhD, he joined the group led by Stefan Knapp at the SGC Frankfurt as a postdoc, where he was funded by the Wellcome Trust, working on the structure-based development of selective and potent CaMK1D kinase inhibitors for the treatment of highly aggressive subtypes of breast cancer. Afterwards he worked at the Frankfurt Cancer Institute (FCI) as a staff scientist where, among other things, he was responsible for developing a comprehensive screening platform for kinases. In the beginning of 2022, Andreas became a principal investigator and is responsible for running the X-ray crystallography facility unit. His current research interests focus primarily on the structural biology of kinases and E3 ligases.
Mandel S, Hanke T, Mathea S, Chatterjee D, Saraswati H, Berger BT, Schwalm MP, Yamamoto S, Tawada M, Takagi T, Ahmed M, Röhm S, Corrionero A, Alfonso P, Baena M, Elson L, Menge A, Krämer A, Pereira R, Müller S, Krause DS, Knapp S
ACS Chem Biol. 2025-4-14 . .doi: 10.1021/acschembio.5c00097
PMID: 40227881Sander P, Schwalm MP, Krämer A, Elson L, Rasch A, Masberg B, Selig R, Sievers-Engler A, Lämmerhofer M, Müller S, Knapp S, Albrecht W, Laufer SA
J Med Chem. 2024-12-17 . .doi: 10.1021/acs.jmedchem.4c02552
PMID: 39681301Zhu WF, Franz HM, Krämer A, Duman E, Empel C, Göbel MW, Koenigs RM, Knapp S, Hiesinger K, Proschak E, Hernandez-Olmos V
J Org Chem. 2024-10-23 . .doi: 10.1021/acs.joc.4c01622
PMID: 39438325Ong HW, Yang X, Smith JL, Taft-Benz S, Howell S, Dickmander RJ, Havener TM, Sanders MK, Brown JW, Couñago RM, Chang E, Krämer A, Moorman NJ, Heise M, Axtman AD, Drewry DH, Willson TM
Molecules. 2024-9-14 . 29(17): .doi: 10.3390/molecules29174158
PMID: 39275006Krämer A, Knapp S
Signal Transduct Target Ther. 2024-9-6 . 9(1):224 .doi: 10.1038/s41392-024-01935-9
PMID: 39237495Gerninghaus J, Zhubi R, Krämer A, Karim M, Tran DHN, Joerger AC, Schreiber C, Berger LM, Berger BT, Ehret TAL, Elson L, Lenz C, Saxena K, Müller S, Einav S, Knapp S, Hanke T
J Med Chem. 2024-7-19 . .doi: 10.1021/acs.jmedchem.4c00411
PMID: 39028937Greco FA, Krämer A, Wahl L, Elson L, Ehret TAL, Gerninghaus J, Möckel J, Müller S, Hanke T, Knapp S
Eur J Med Chem. 2024-7-14 . 276:116672 .doi: 10.1016/j.ejmech.2024.116672
PMID: 39067440Ong HW, Yang X, Smith JL, Dickmander RJ, Brown JW, Havener TM, Taft-Benz S, Howell S, Sanders MK, Capener JL, Couñago RM, Chang E, Krämer A, Moorman NJ, Heise M, Axtman AD, Drewry DH, Willson TM
J Med Chem. 2024-7-3 . .doi: 10.1021/acs.jmedchem.4c00962
PMID: 38959455Muñoz Sosa CJ, Lenz C, Hamann A, Farges F, Dopfer J, Krämer A, Cherkashyna V, Tarnovskiy A, Moroz YS, Proschak E, Němec V, Müller S, Saxena K, Knapp S
ACS Chem Biol. 2024-6-27 . .doi: 10.1021/acschembio.4c00301
PMID: 38934237Balourdas DI, Markl AM, Krämer A, Settanni G, Joerger AC
Cell Death Dis. 2024-6-11 . 15(6):408 .doi: 10.1038/s41419-024-06739-x
PMID: 38862470