Sandra Röhm studied Biomedicinal Chemistry at the Johannes Gutenberg University and at the Max Planck Institute for Polymer Research in Mainz. For her scientific achievements in the field of Chemistry, she was awarded with the Adolf Todt prize from the University of Mainz. In 2015 she joined Professor Stefan Knapp‘s group and the Structural Genomics Consortium in Frankfurt. During her Ph.D. studies, she successfully developed chemical probes targeting the mitogen activated protein kinase p38 and the discoidin domain receptor kinase. In 2020 she continued as a postdoc and worked on kinase inhibitors for Parkinson's disease. As leader of WP2 in the EUbOPEN Consortium, she is coordinating the effort to generate a chemogenomic compound library. Together with her team, her current research interests focus on the design of covalent and allosteric inhibitors with structural novelties.
Wang G, Seidler NJ, Röhm S, Pan Y, Liang XJ, Haarer L, Berger BT, Sivashanmugam SA, Wydra VR, Forster M, Laufer SA, Chaikuad A, Gehringer M, Knapp S
Angew Chem Int Ed Engl. 2024-12-24 . e202419736 .doi: 10.1002/anie.202419736
PMID: 39716901Angela Kwak H, Liu L, Tredup C, Röhm S, Prinos P, Böttcher J, Schapira M
Drug Discov Today. 2024-8-21 . 104144 .doi: 10.1016/j.drudis.2024.104144
PMID: 39179147Tredup C, Ndreshkjana B, Schneider NS, Tjaden A, Kemas AM, Youhanna S, Lauschke VM, Berger BT, Krämer A, Berger LM, Röhm S, Knapp S, Farin HF, Müller S
ACS Chem Biol. 2023-3-21 . .doi: 10.1021/acschembio.2c00877
PMID: 36944371Schwalm MP, Berger LM, Meuter MN, Vasta JD, Corona CR, Röhm S, Berger BT, Farges F, Beinert SM, Preuss F, Morasch V, Rogov VV, Mathea S, Saxena K, Robers MB, Müller S, Knapp S
Front Cell Dev Biol. 2022-6-21 . 10:886537 .doi: 10.3389/fcell.2022.886537
PMID: 35721509Röhm S, Berger BT, Schröder M, Chatterjee D, Mathea S, Joerger AC, Pinkas DM, Bufton JC, Tjaden A, Kovooru L, Kudolo M, Pohl C, Bullock AN, Müller S, Laufer S, Knapp S
J Med Chem. 2021-9-10 . .doi: 10.1021/acs.jmedchem.1c00868
PMID: 34506142Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S
Eur J Med Chem. 2020-8-20 . 208:112721 .doi: 10.1016/j.ejmech.2020.112721
PMID: 33035818Röhm S, Berger BT, Schröder M, Chaikuad A, Winkel R, Hekking KFW, Benningshof JJC, Mueller G, Tesch R, Kudolo M, Forster M, Laufer SA, Knapp S
J. Med. Chem.. 2019-11-8 . .doi: 10.1021/acs.jmedchem.9b01227
PMID: 31702918