Hui Peng

Hui Peng

SGC Toronto

Peng

Hui Peng

416-978-3596
Lash Miller Chemical Laboratories, 80 St. George Street, Toronto, ON, M5S 3H6

Affiliations

Research Areas

Research in our group relies on the interface between chemistry and biology to answer fundamental environmental questions. We focus on the development of novel techniques to address the following bottlenecks of current environmental science research: i) the limited capacity of traditional targeted chemical analysis strategies to monitor the growing number of known and unknown environmental chemicals introduced into commerce ; ii) limited information is available regarding toxic mechanisms (i.e., protein targets) for the vast majority of environmental chemicals. We are currently focusing on three research directions: 

  • Untargeted identification of novel environmental chemicals
  • Investigation on sources and behaviors of environmental chemicals
  • Unbiased identification of protein targets by chemical proteomics
     

2021

Prediction and Validation of a Protein's Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence.

Peng X, Baxa M, Faruk N, Sachleben JR, Pintscher S, Gagnon IA, Houliston S, Arrowsmith CH, Freed KF, Rocklin GJ, Sosnick TR

J Chem Theory Comput. 2021-12-22 . .doi: 10.1021/acs.jctc.1c00960

PMID: 34936354

Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.

Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP

J Med Chem. 2021-11-22 . .doi: 10.1021/acs.jmedchem.1c00804

PMID: 34807584

2018

Architecture of the native major royal jelly protein 1 oligomer.

Tian W, Li M, Guo H, Peng W, Xue X, Hu Y, Liu Y, Zhao Y, Fang X, Wang K, Li X, Tong Y, Conlon MA, Wu W, Ren F, Chen Z

Nat Commun. 2018-8-22 . 9(1):3373 .doi: 10.1038/s41467-018-05619-1

PMID: 30135511