Research in our group relies on the interface between chemistry and biology to answer fundamental environmental questions. We focus on the development of novel techniques to address the following bottlenecks of current environmental science research: i) the limited capacity of traditional targeted chemical analysis strategies to monitor the growing number of known and unknown environmental chemicals introduced into commerce ; ii) limited information is available regarding toxic mechanisms (i.e., protein targets) for the vast majority of environmental chemicals. We are currently focusing on three research directions:
Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Müller S, Knapp S, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, Halabelian L
bioRxiv. 2025-2-3 . .doi: 10.1101/2025.01.17.633682
PMID: 39896675Peng X, Baxa M, Faruk N, Sachleben JR, Pintscher S, Gagnon IA, Houliston S, Arrowsmith CH, Freed KF, Rocklin GJ, Sosnick TR
J Chem Theory Comput. 2021-12-22 . .doi: 10.1021/acs.jctc.1c00960
PMID: 34936354Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP
J Med Chem. 2021-11-22 . .doi: 10.1021/acs.jmedchem.1c00804
PMID: 34807584Tian W, Li M, Guo H, Peng W, Xue X, Hu Y, Liu Y, Zhao Y, Fang X, Wang K, Li X, Tong Y, Conlon MA, Wu W, Ren F, Chen Z
Nat Commun. 2018-8-22 . 9(1):3373 .doi: 10.1038/s41467-018-05619-1
PMID: 30135511