Hui Peng

Hui Peng

SGC Toronto

Peng

Hui Peng

416-978-3596
Lash Miller Chemical Laboratories, 80 St. George Street, Toronto, ON, M5S 3H6

Affiliations

Research Areas

Research in our group relies on the interface between chemistry and biology to answer fundamental environmental questions. We focus on the development of novel techniques to address the following bottlenecks of current environmental science research: i) the limited capacity of traditional targeted chemical analysis strategies to monitor the growing number of known and unknown environmental chemicals introduced into commerce ; ii) limited information is available regarding toxic mechanisms (i.e., protein targets) for the vast majority of environmental chemicals. We are currently focusing on three research directions: 

  • Untargeted identification of novel environmental chemicals
  • Investigation on sources and behaviors of environmental chemicals
  • Unbiased identification of protein targets by chemical proteomics
     

2025

Chemical proteomics reveals human liver fatty acid binding protein as a predominant and selective target of triphenyl phosphate.

Miller J, Han J, Yang D, Diamond ML, Liu R, Peng H

Environ Sci Process Impacts. 2025-8-20 . .doi: 10.1039/d5em00327j

PMID: 40833013

Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling.

Fan X, Li X, Li T, Shao B, Niu S, Fan W, Wang Q, Zhong L, Wang X, Wang Z, Ma F, Zheng G, Peng H, Chen L, Dong Z

Environ Int. 2025-6-11 . 201:109591 .doi: 10.1016/j.envint.2025.109591

PMID: 40494107

Semiquantitative Nontargeted Screening of Organophosphorus Plastic Additives in Consumer Products Using (31)P NMR.

Chen W, Miller JM, Burns DC, Almuhtaram H, Andrews RC, Peng H

Environ Sci Technol. 2025-6-2 . 59(23):11842-11852 .doi: 10.1021/acs.est.5c02789

PMID: 40455101

Structure and Toxicity Characterization of Alkyl Hydroxylated Metabolites of 6PPD-Q.

Nair P, Barrett H, Tanoto K, Xie L, Sun J, Yang D, Yao H, Song D, Peng H

Environ Sci Technol. 2025-4-8 . 59(15):7474-7484 .doi: 10.1021/acs.est.4c11823

PMID: 40197020

Enantioselective Protein Affinity Selection Mass Spectrometry (EAS-MS).

Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Müller S, Knapp S, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, Halabelian L

bioRxiv. 2025-2-3 . .doi: 10.1101/2025.01.17.633682

PMID: 39896675

2021

Prediction and Validation of a Protein's Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence.

Peng X, Baxa M, Faruk N, Sachleben JR, Pintscher S, Gagnon IA, Houliston S, Arrowsmith CH, Freed KF, Rocklin GJ, Sosnick TR

J Chem Theory Comput. 2021-12-22 . .doi: 10.1021/acs.jctc.1c00960

PMID: 34936354

Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.

Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L, Peng Y, Dong J, Celeridad M, Layng F, Knapp S, Cosford NDP

J Med Chem. 2021-11-22 . .doi: 10.1021/acs.jmedchem.1c00804

PMID: 34807584

2018

Architecture of the native major royal jelly protein 1 oligomer.

Tian W, Li M, Guo H, Peng W, Xue X, Hu Y, Liu Y, Zhao Y, Fang X, Wang K, Li X, Tong Y, Conlon MA, Wu W, Ren F, Chen Z

Nat Commun. 2018-8-22 . 9(1):3373 .doi: 10.1038/s41467-018-05619-1

PMID: 30135511