Frances Bashore

Frances Bashore

SGC UNC

Bashore

Frances Bashore

Affiliations

UNC Eshelman School of Pharmacy

Biography

Frankie obtained her Master of Chemistry degree from the University of Liverpool, UK, and completed her PhD in Medicinal Chemistry under the supervision of Dr Craig Jamieson at The University of Strathclyde, UK. She continued research as a Chemical Biology Postdoctoral Research Associate in the Center for Integrative Chemical Biology and Drug Discovery (CICBDD) at UNC under the supervision of Prof Stephen Frye and Prof Lindsey James. Postdoctoral research focused on the design, synthesis, and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) for epigenetic regulators such as Polycomb Repressive Complex 2 (PRC2).

  • All Publications

2025

Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve.

Min SM, Bashore FM, Smith JL, Havener TM, Howell S, Li H, Couñago RM, Popov KI, Axtman AD

J Med Chem. 2025-1-22 . .doi: 10.1021/acs.jmedchem.4c02531

PMID: 39838960

2024

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.

Bashore FM, Min SM, Chen X, Howell S, Rinderle CH, Morel G, Silvaroli JA, Wells CI, Bunnell BA, Drewry DH, Pabla NS, Ultanir SK, Bullock AN, Axtman AD

ACS Med Chem Lett. 2024-8-8 . 15(8):1325-1333 .doi: 10.1021/acsmedchemlett.4c00219

PMID: 39140040

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.

Bashore FM, Katis VL, Du Y, Sikdar A, Wang D, Bradshaw WJ, Rygiel KA, Leisner TM, Chalk R, Mishra S, Williams CA, Gileadi O, Brennan PE, Wiley JC, Gockley J, Cary GA, Carter GW, Young JE, Pearce KH, Fu H, Axtman AD

PLoS One. 11.07.2024. 19(2):e0293548 .doi: 10.1371/journal.pone.0293548

PMID: 38359047

2023

Fused Tetrahydroquinolines Are Interfering with Your Assay.

Bashore FM, Annor-Gyamfi J, Du Y, Katis V, Nwogbo F, Flax RG, Frye SV, Pearce KH, Fu H, Willson TM, Drewry DH, Axtman AD

J Med Chem. 2023-10-24 . .doi: 10.1021/acs.jmedchem.3c01277

PMID: 37874947

Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.

Du Y, Bradshaw WJ, Leisner TM, Annor-Gyamfi JK, Qian K, Bashore FM, Sikdar A, Nwogbo FO, Ivanov AA, Frye SV, Gileadi O, Brennan PE, Levey AI, Axtman AD, Pearce KH, Fu H, Katis VL

J Biol Chem. 2023-10-20 . 105382 .doi: 10.1016/j.jbc.2023.105382

PMID: 37866628

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.

Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir S, Axtman AD

Elife. 2023-7-25 . 12: .doi: 10.7554/eLife.88206

PMID: 37490324

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.

Bashore FM, Marquez AB, Chaikuad A, Howell S, Dunn AS, Beltran AA, Smith JL, Drewry DH, Beltran AS, Axtman AD

Sci Rep. 2023-4-14 . 13(1):6118 .doi: 10.1038/s41598-023-32854-4

PMID: 37059819

Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.

Davis-Gilbert ZW, Krämer A, Dunford JE, Howell S, Senbabaoglu F, Wells CI, Bashore FM, Havener TM, Smith JL, Hossain MA, Oppermann U, Drewry DH, Axtman AD

ACS Med Chem Lett. 2023-4-13 . 14(4):432-441 .doi: 10.1021/acsmedchemlett.2c00530

PMID: 37077385