Mario Henrique Bengtson

Mario Henrique Bengtson

SGC Unicamp

Bengtson

Biography

Dr. Bengtson holds a PhD in Biochemistry and Molecular Biology from São Paulo University (USP), awarded in 2002. He completed two postdoctoral fellowships: the first at the Genomics Institute of the Novartis Research Foundation (GNF) from 2003 to 2006, and the second at The Scripps Research Institute from 2007 to 2012. Since 2013, he has been an assistant professor at UNICAMP.

Research Areas

Dr. Bengtson’s lab is dedicated to studying translational ubiquitination and degradation of proteins, as well as the translational regulation of gene expression. The lab also investigates how failures in these mechanisms are implicated in human diseases.

2023

Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.

Takarada JE, Cunha MR, Almeida VM, Vasconcelos SNS, Santiago AS, Godoi PH, Salmazo A, Ramos PZ, Fala AM, de Souza LR, Da Silva IEP, Bengtson MH, Massirer KB, Couñago RM

Bioorg Med Chem. 2023-12-20 . 98:117561 .doi: 10.1016/j.bmc.2023.117561

PMID: 38157838

2022

Genome-wide translation control analysis of developing human neurons.

Lins ÉM, Oliveira NCM, Reis O, Ferrasa A, Herai R, Muotri AR, Massirer KB, Bengtson MH

Mol Brain. 2022-6-15 . 15(1):55 .doi: 10.1186/s13041-022-00940-9

PMID: 35706057

2020

Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

Silva SF, Klippel AH, Ramos PZ, Santiago ADS, Valentini SR, Bengtson MH, Massirer KB, Bilsland E, Couñago RM, Zanelli CF

PLoS Negl Trop Dis. 2020-10-12 . 14(10):e0008762 .doi: 10.1371/journal.pntd.0008762

PMID: 33044977

Translational Control during Mammalian Neocortex Development and Postembryonic Neuronal Function.

Oliveira NCM, Lins ÉM, Massirer KB, Bengtson MH

Semin Cell Dev Biol. 2020-10-2 . .doi: 10.1016/j.semcdb.2020.09.006

PMID: 33020045

2015

Preclinical target validation using patient-derived cells.

Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M, Barker P, Barsyte D, Bengtson MH, Bell C, Bowness P, Boycott KM, Buser-Doepner C, Carpenter CL, Carr AJ, Clark K, Das AM, Dhanak D, Dirks P, Ellis J, Fantin VR, Flores C, Fon EA, Frail DE, Gileadi O, O'Hagan RC, Howe T, Isaac JT, Jabado N, Jakobsson PJ, Klareskog L, Knapp S, Lee WH, Lima-Fernandes E, Lundberg IE, Marshall J, Massirer KB, MacKenzie AE, Maruyama T, Mueller-Fahrnow A, Muthuswamy S, Nanchahal J, O'Brien C, Oppermann U, Ostermann N, Petrecca K, Pollock BG, Poupon V, Prinjha RK, Rosenberg SH, Rouleau G, Skingle M, Slutsky AS, Smith GA, Verhelle D, Widmer H, Young LT

Nat Rev Drug Discov. 2015-2-20 . 14(3):149-50 .doi: 10.1038/nrd4565

PMID: 25722227