Rational discovery of therapeutic PAK1 allosteric activators.

He Y, Bae JSH, Nowak E, Outeiral C, Nissley DA, Tumber A, Berridge G, Salah E, Wang Y, He W, Zhang H, Chen T, Tusk S, Mathea S, Wang YJ, Grassam-Rowe A, Kukura P, Schofield CJ, O'Brien DP, Pierangelini A, Churchill GC, Lanyon-Hogg T, Ke Y, Xu C, Ye T, Watkins H, Ying L, Koschinski A, Solaro RJ, Tan X, Bolla JR, Wang X, Knapp S, Deane CM, Zaccolo M, Nowotny M, Lei M