Discovery of APO-50815, a potent WEE1 kinase inhibitor with exceptional efficacy against patient-derived colorectal cancer organoids.

Syphers JL, Wright JA, de Nys R, Silva TN, Vrbanac L, Barratt KR, Leeflang J, Hasan ST, Thomson SF, Kumar A, Krämer A, Lenz C, Gee YS, Chang A, Young S, Sloan EK, Knapp S, Worthley DL, Mukherjee S, Stockton K, Priebbenow DL, Woods SL, Baell JB