CLK1 with bound pyridoquinazoline inhibitor

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.

Tazarki, H., Zeinyeh, W., Esvan, Y.J., Knapp, S., Chatterjee, D., Schroder, M., Joerger, A.C., Khiari, J., Josselin, B., Baratte, B., Bach, S., Ruchaud, S., Anizon, F., Giraud, F., Moreau, P.

(2019) Eur J Med Chem 166: 304-317

    PubMed: 30731399