Václav Němec studied Chemistry (BSc.) and later on also Organic Chemistry (MSc. and PhD.) at Masaryk University in Brno, Czech Republic. During his studies in Brno he was involved in several med-chem and chemical biology projects focusing for instance on development of novel kinase inhibitors (CLKs, CK1, ALKs) or inhibitors of Hedgehog signaling. He has spent 7 months in Manchester (UK) on a research stay in laboratories of Prof. David Procter, where he was working on the synthesis of natural product Phaeocaulising based on SmI2 mediated radical cascade reaction. Owing to Jean Marie Lehn scholarship, he spent also one month at EICB Bordeaux (France) in the research group of Prof. Frédéric Friscourt, where he was working on a chemo-enzymatic synthesis of poly-LacNAc chains for binding and study of lectins. In September 2020 he has joined the SGC node at Goethe University in Frankfurt where he is working on development of novel PROTACs and establishment of chemogenomic library.
Miletić N, Weckesser J, Mosler T, Rathore R, Hoffmann ME, Gehrtz P, Schlesiger S, Hartung IV, Berner N, Wilhelm S, Müller J, Adhikari B, Němec V, Sivashanmugam SA, Elson L, Holzmann H, Schwalm MP, Hoffmann L, Abdul Azeez KR, Müller S, Kuster B, Wolf E, Đikić I, Knapp S
ACS Chem Biol. 2025-2-11 . .doi: 10.1021/acschembio.4c00812
PMID: 39932098Haag A, Němec V, Janovská P, Bartošíková J, Adhikari B, Müller J, Schwalm MP, Čada Š, Ohmayer U, Daub H, Kim Y, Born F, Wolf E, Bryja V, Knapp S
J Med Chem. 2024-12-27 . .doi: 10.1021/acs.jmedchem.4c02201
PMID: 39729064Němec V, Remeš M, Beňovský P, Böck MC, Šranková E, Wong JF, Cros J, Williams E, Tse LH, Smil D, Ensan D, Isaac MB, Al-Awar R, Gomolková R, Ursachi VC, Fafílek B, Kahounová Z, Víchová R, Vacek O, Berger BT, Wells CI, Corona CR, Vasta JD, Robers MB, Krejci P, Souček K, Bullock AN, Knapp S, Paruch K
J Med Chem. 2024-7-18 . .doi: 10.1021/acs.jmedchem.4c00629
PMID: 39023313Muñoz Sosa CJ, Lenz C, Hamann A, Farges F, Dopfer J, Krämer A, Cherkashyna V, Tarnovskiy A, Moroz YS, Proschak E, Němec V, Müller S, Saxena K, Knapp S
ACS Chem Biol. 2024-6-27 . .doi: 10.1021/acschembio.4c00301
PMID: 38934237Němec V, Schwalm MP, Müller S, Knapp S
Chem Soc Rev. 2022-8-25 . .doi: 10.1039/d2cs00478j
PMID: 36004812Němec V, Maier L, Berger BT, Chaikuad A, Drápela S, Souček K, Knapp S, Paruch K
Eur J Med Chem. 2021-2-18 . 215:113299 .doi: 10.1016/j.ejmech.2021.113299
PMID: 33636538Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schroeder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, Paruch K
Angew. Chem. Int. Ed. Engl.. 2018-12-20 . .doi: 10.1002/anie.201810312
PMID: 30569600