Rafael Junqueira Borges

Rafael Junqueira Borges

SGC Unicamp

Borges

Rafael Junqueira Borges

rjborges@unicamp.br
Av. Cândido Rondon, 400 - Cidade Universitária, Campinas - SP 13083-875
ORCID Google Scholar

Affiliations

Principal Investigator in the Center For Medicinal Chemistry (CQMED) Researcher in the Center for Molecular Biology and Genetics Engineering (CBMEG) Universidade Estadual de Campinas (UNICAMP)
Group Profile

Biography

Rafael Junqueira Borges, PhD and specialist in Structural Biology, Bioinformatics and Method Development, is a Principal Investigator in the CQMED and the head of LaBEI/CBMEG/UNICAMP. His group integrates experimental and computational methods to understand protein structure and function, focusing on the search for modulators/inhibitors of therapeutic targets in the early phase of drug discovery. His group combines structural biology, biophysical and biochemical assays, mass spectrometry, phylogenetic analysis, structural bioinformatics, chemoinformatics, and artificial intelligence to elucidate structures, complexes, and sequences. We study proteins from natural sources, especially snake venom toxins, and cancer-related targets.

Research Areas

  1. The two crystal structures of unloaded and cargo-loaded Vacuolar Sorting Receptor 1 lumenal domain (VSR1-Nt) reveal two cargo binding sites and a mechanism of transport
  2. The CCP4 suite: integrative software for macromolecular crystallography
  3. SEQUENCE SLIDER: integration of structural and genetic data to characterize isoforms from natural sources
  4. SEQUENCE SLIDER: expanding polyalanine fragments for phasing with multiple side-chain hypotheses
  5. PLA2-like proteins myotoxic mechanism: a dynamic model description
  • All Publications

2020

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.

Gütschow M, Eynde JJV, Jampilek J, Kang C, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, Muñoz-Torrero D

Molecules. 2020-6-28 . 25(13): .doi: 10.3390/molecules25132968

PMID: 32605268

2019

Insights into the full-length SRPK2 structure and its hydrodynamic behavior.

de Almeida Alves Barbosa É, Seraphim TV, Gandin CA, Teixeira LF, da Silva RAG, Righetto GL, Goncalves KA, de Souza Vasconcellos R, de Almeida Lamêgo MR, Júnior AS, Fietto JLR, Kobarg J, Gileadi C, Massirer KB, Borges JC, de Oliveira Neto M, Bressan GC

Int. J. Biol. Macromol.. 2019-6-20 . .doi: 10.1016/j.ijbiomac.2019.06.135

PMID: 31229549