Chemical Handles for E3 ligases

The table below contains the entire collection of SGC’s E3 chemical handles. To browse the collection, find associated data, or acquire samples, select the desired chemical probe in the table below and follow the links that appear on that page. You can sort the table by clicking the column headers. To acquire a sample, follow the links on the webpage of your desired chemical handle.

04.04.2024

Bridging the Gap Between Leukemia Research and Real-Life Impact

by: SGC

As scientists, our training equips us to think creatively, tackle setbacks in the lab, and always ponder “What's next?" after publishing our findings. Yet, one area where our preparation might falter is in grasping the real-world impact of our work. Often, we might feel our efforts like a single experiment might be too small to tackle big healthcare challenges like cancer. However, it takes just one patient, one story, to put everything into perspective.

Protein: WDR41
PDB ID: 8W3V
Deposition Date: Thursday 22nd February 2024
Authors: Hutchinson, A., Dong, A., Li, Y., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Halabelian, L.
Protein: TCDB
PDB ID: 8QEN
Deposition Date: Friday 1st September 2023
Authors: Kinsolving, J., Bous, J.
Protein: CDYL2
PDB ID: 8SP6
Deposition Date: Tuesday 2nd May 2023
Authors: Song, X., Beldar, S., Dong, A., Arrowsmith, C.H., Edwards, A.M., Min, J.
Protein: HASPIN
PDB ID: 8RDK
Deposition Date: Friday 8th December 2023
Related Diseases: Drug metabolism and toxicology
Authors: Kraemer, A., Defois, M., Giraud, F., Moreau, P., Anizon, F., Knapp, S.
Site: Toronto
Protein: CECR2
PDB ID: 8RU1
Deposition Date: Monday 29th January 2024
Authors: Fairhead, M., Strain-Damerell, C., Ye, M., Mackinnon, S.R., Pinkas, D., MacLean, E.M., Koekemoer, L., Damerell, D., Krojer, T., Arrowsmith, C.H., Edwards, A., Bountra, C., Yue, W., Burgess-Brown, N., Marsden, B., von Delft, F.
Protein: ATAD2
PDB ID: 8RU5
Deposition Date: Tuesday 30th January 2024
Authors: Fairhead, M., Strain-Damerell, C., Ye, M., Mackinnon, S.R., Pinkas, D., MacLean, E.M., Koekemoer, L., Damerell, D., Krojer, T., Arrowsmith, C.H., Edwards, A., Bountra, C., Yue, W., Burgess-Brown, N., Marsden, B., von Delft, F.
Protein: EPHX2
PDB ID: 8QZD
Deposition Date: Friday 27th October 2023
Authors: Kumar, A., Ehrler, J.M.H., Ziegler, S., Doetsch, L., Proschak, E., Knapp, S.
Protein: CARM1
PDB ID: 8G2I
Deposition Date: Friday 3rd February 2023
Authors: Song, X., Dong, A., Deng, Y., Huang, R., Arrowsmith, C.H., Edwards, A.M., Min, J.