Originally from Dublin, Ireland, Thomas Durcan, PhD has been at the Montreal Neurological Institute (The Neuro) since 2007. As an Associate Professor at The Neuro and McGill University (https://www.youtube.com/watch?v=kuO2IKE4JME), his research focus is on applying patient-derived induced pluripotent stem cells (IPSCs) towards the development of phenotypic discovery assays and 3D mini-brain models (https://www.youtube.com/watch?v=zjOS_trumik) for both neurodegenerative and neurodevelopmental disorders.
As Director of the EDDU at The Neuro, he oversees a team of over 40 research staff and students, committed to applying novel stem cell technology, combined with CRISPR genome editing, mini-brain models and new microfluidic technologies towards elucidating the underlying causes of these complex disorders. Combined with new approaches in the group towards building multi-omics profiles on the patient-derived IPSC cells, the long-term strategy is to identify new personalized precision therapies. Dr. Durcan's academic research program is funded by a CIHR program grant and USA Department of Defense Research grants.
Flax RG, Rosston P, Rocha C, Anderson B, Capener JL, Durcan TM, Drewry DH, Prinos P, Axtman AD
Front Mol Biosci. 11.07.2024. 11:1352781 .doi: 10.3389/fmolb.2024.1352781
PMID: 38523660Eldeeb MA, Bayne AN, Fallahi A, Goiran T, MacDougall EJ, Soumbasis A, Zorca CE, Tabah JJ, Thomas RA, Karpilovsky N, Mathur M, Durcan TM, Trempe JF, Fon EA
Proc Natl Acad Sci U S A. 2024-3-5 . 121(10):e2313540121 .doi: 10.1073/pnas.2313540121
PMID: 38416681Ayoubi R, Ryan J, Biddle MS, Alshafie W, Fotouhi M, Bolivar SG, Ruiz Moleon V, Eckmann P, Worrall D, McDowell I, Southern K, Reintsch W, Durcan TM, Brown C, Bandrowski A, Virk H, Edwards AM, McPherson P, Laflamme C
Elife. 2023-11-23 . 12: .doi: 10.7554/eLife.91645
PMID: 37995198Durcan TM, Axtman AD
Front Cell Neurosci. 2023-5-1 . 17:1196543 .doi: 10.3389/fncel.2023.1196543
PMID: 37124399Alshafie W, Fotouhi M, Shlaifer I, Ayoubi R, Edwards AM, Durcan TM, McPherson PS, Laflamme C
F1000Res. 2022-12-7 . 11:977 .doi: 10.12688/f1000research.124632.2
PMID: 36415206Krahn AI, Wells C, Drewry DH, Beitel LK, Durcan TM, Axtman AD
ACS Chem Neurosci. 2020-5-28 . .doi: 10.1021/acschemneuro.0c00176
PMID: 32464049Laflamme C, McKeever PM, Kumar R, Schwartz J, Kolahdouzan M, Chen CX, You Z, Benaliouad F, Gileadi O, McBride HM, Durcan TM, Edwards AM, Healy LM, Robertson J, McPherson PS
Elife. 2019-10-15 . 8: .doi: 10.7554/eLife.48363
PMID: 31612854