Mat Todd was born in Manchester, England. He obtained his PhD in organic chemistry from Cambridge University in 1999. He was a Wellcome Trust postdoctoral scholar at The University of California, Berkeley, a college fellow at Cambridge University, a lecturer at Queen Mary, University of London. Between 2005 and 2018, Mat was at the School of Chemistry, The University of Sydney. He is now Chair of Drug Discovery at University College London (UCL).
Mat’s research interests include the development of new ways to make molecules then finding out what those molecules do and why. He has a significant interest in open science and how it may be used to accelerate research, with particular emphasis on open source discovery of new medicines. He founded and currently leads the Open Source Malaria (OSM), Mycetoma (MycetOS), Tuberculosis (OSTB) and Antibiotics (AntibiOS) consortia, and is a founder of a broader Open Source Pharma movement. He is on the editorial boards of PLoS One, ChemistryOpen, Nature Scientific Reports and SciPost Chemistry.
In 2011, he was awarded a New South Wales Scientist of the Year award in the Emerging Research category for his work in open science and, in 2012, the OSM consortium was awarded one of three Wellcome Trust/Google/PLoS Accelerating Science Awards. For his open source research, Mat was selected for the Medicine Maker’s Power List in 2017–2021.
Ghoshal A, Magalhães ÁF, Asressu KH, Hossain MA, Todd MH, Willson TM
Pharmaceuticals (Basel). 2024-6-26 . 17(7): .doi: 10.3390/ph17070836
PMID: 39065687Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L
Nat Commun. 2024-1-31 . 15(1):937 .doi: 10.1038/s41467-024-45224-z
PMID: 38297033Klug DM, Tse EG, Silva DG, Cao Y, Charman SA, Chauhan J, Crighton E, Dichiara M, Drake C, Drewry D, da Silva Emery F, Ferrins L, Graves L, Hopkins E, Kresina TAC, Lorente-MacÃas Ã, Perry B, Phipps R, Quiroga B, Quotadamo A, Sabatino GN, Sama A, Schätzlein A, Simpson QJ, Steele J, Shanu-Wilson J, Sjö P, Stapleton P, Swain CJ, Vaideanu A, Xie H, Zuercher W, Todd MH
ACS Infect Dis. 2023-11-22 . .doi: 10.1021/acsinfecdis.3c00286
PMID: 37991879Tilley L, Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje CF, Dunn E, Luth M, Kumpornsin K, Istvan E, Park J, Fairhurst K, Yeo T, Yildirim O, Bhebhe M, Klug D, Rutledge P, Godoy L, Dey S, De Souza M, Siqueira-Neto J, Ketprasit N, Du Y, Amini M, Shami G, Nie S, Williamson N, Jana G, Maity B, Thomson P, Foley T, Loesbanluechai D, Puhalovich T, Tan D, Niles J, Han BW, Goldberg D, Burrows J, Fidock D, Lee M, Winzeler E, Griffin M, Todd M
Res Sq. 2023-7-27 . .doi: 10.21203/rs.3.rs-3198291/v1
PMID: 37546892Ackloo S, Antolin AA, Bartolome JM, Beck H, Bullock A, Betz UAK, Böttcher J, Brown PJ, Chaturvedi M, Crisp A, Daniels D, Dreher J, Edfeldt K, Edwards AM, Egner U, Elkins J, Fischer C, Glendorf T, Goldberg S, Hartung IV, Hillisch A, Homan E, Knapp S, Köster M, Krämer O, Llaveria J, Lessel U, Lindemann S, Linderoth L, Matsui H, Michel M, Montel F, Mueller-Fahrnow A, Müller S, Owen DR, Saikatendu KS, Santhakumar V, Sanderson W, Scholten C, Schapira M, Sharma S, Shireman B, Sundström M, Todd MH, Tredup C, Venable J, Willson TM, Arrowsmith CH
RSC Med Chem. 2023-6-22 . 14(6):1002-1011 .doi: 10.1039/d2md00441k
PMID: 37360399Ackloo S, Al-Awar R, Amaro RE, Arrowsmith CH, Azevedo H, Batey RA, Bengio Y, Betz UAK, Bologa CG, Chodera JD, Cornell WD, Dunham I, Ecker GF, Edfeldt K, Edwards AM, Gilson MK, Gordijo CR, Hessler G, Hillisch A, Hogner A, Irwin JJ, Jansen JM, Kuhn D, Leach AR, Lee AA, Lessel U, Morgan MR, Moult J, Muegge I, Oprea TI, Perry BG, Riley P, Rousseaux SAL, Saikatendu KS, Santhakumar V, Schapira M, Scholten C, Todd MH, Vedadi M, Volkamer A, Willson TM
Nat Rev Chem. 2022-7-6 . 6(4):287-295 .doi: 10.1038/s41570-022-00363-z
PMID: 35783295Müller S, Ackloo S, Al Chawaf A, Al-Lazikani B, Antolin A, Baell JB, Beck H, Beedie S, Betz UAK, Bezerra GA, Brennan PE, Brown D, Brown PJ, Bullock AN, Carter AJ, Chaikuad A, Chaineau M, Ciulli A, Collins I, Dreher J, Drewry D, Edfeldt K, Edwards AM, Egner U, Frye SV, Fuchs SM, Hall MD, Hartung IV, Hillisch A, Hitchcock SH, Homan E, Kannan N, Kiefer JR, Knapp S, Kostic M, Kubicek S, Leach AR, Lindemann S, Marsden BD, Matsui H, Meier JL, Merk D, Michel M, Morgan MR, Mueller-Fahrnow A, Owen DR, Perry BG, Rosenberg SH, Saikatendu KS, Schapira M, Scholten C, Sharma S, Simeonov A, Sundström M, Superti-Furga G, Todd MH, Tredup C, Vedadi M, von Delft F, Willson TM, Winter GE, Workman P, Arrowsmith CH
RSC Med Chem. 2022-1-27 . 13(1):13-21 .doi: 10.1039/d1md00228g
PMID: 35211674